FlyBase Allele Report: Dmel\Tgi[GD7081]

General Information

Symbol

Dmel\Tgi^GD7081

Species

D. melanogaster

Name

FlyBase ID

FBal0199138

Feature type

allele

Associated gene

Dmel\Tgi

Associated Insertion(s)

Carried in Construct

P{GD7081}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7081}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7081

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of Tgi^GD7081 under the control of Scer\GAL4^GMR.PF (co-expressed with Dcr-2^Scer\UAS.cDa) has no effect on eye disc apoptosis in third instar larvae.

(Koontz et al., 2013)

Adults expressing Tgi^GD7081 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 100% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7081

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tgi^GD7081/Scer\GAL4^GMR.PF is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Koontz et al., 2013)

Scer\GAL4^nub.PU/Tgi^GD7081 is a suppressor of increased cell death | larval stage phenotype of Scer\GAL4^Bx-MS1096, hpo^UAS.cWa

(Koontz et al., 2013)

Scer\GAL4^nub.PU/Tgi^GD7081 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^Bx-MS1096, hpo^UAS.cWa

(Koontz et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tgi^GD7081/Scer\GAL4^GMR.PF is a suppressor | partially of eye disc | third instar larval stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Koontz et al., 2013)

Tgi^GD7081/Scer\GAL4^GMR.PF is a suppressor | partially of eye disc morphogenetic furrow | third instar larval stage phenotype of Scer\GAL4^GMR.PF, ex^UAS.cBa

(Koontz et al., 2013)

Scer\GAL4^nub.PU/Tgi^GD7081 is a suppressor | somatic clone of wing disc phenotype of Scer\GAL4^Bx-MS1096, hpo^UAS.cWa

(Koontz et al., 2013)

Scer\GAL4^nub.PU/Tgi^GD7081 is a suppressor | somatic clone of wing phenotype of Scer\GAL4^Bx-MS1096, hpo^UAS.cWa

(Koontz et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Tgi^GD7081 (co-expressed with Dcr-2^Scer\UAS.cDa) significantly suppresses the morphogenetic furrow cell death seen when ex^Scer\UAS.cBa is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Tgi^GD7081 (co-expressed with Dcr-2^Scer\UAS.cDa) suppresses the wing disc apoptosis seen when hpo^Scer\UAS.cWa is expressed under the control of Scer\GAL4^nub.PU. The reduction in adult wing size is also partially suppressed.

(Koontz et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v31340

w¹¹¹⁸; P{GD7081}v31340

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7081

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG10741^GD7081

Tgi^GD7081

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close