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General Information
Symbol
Dmel\wakeGD12087
Species
D. melanogaster
Name
FlyBase ID
FBal0205269
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of wakeGD12087 under the control of Scer\GAL4pnr-MD237 causes defects in the establishment of polarity in sensory organ precursor (SOP) cells. Expression of wakeGD12087 causes the formation of external sensory organs that contain two neurons and two sheath cells, indicating a cell transformation of pIIa into pIIb.

Expression of wakeGD12087 in all neuroblasts under the control of Scer\GAL4insc-Mz1407 does not cause an obvious change in neuroblast numbers in the larval brain, however it does produce defects in the basal segregation of mira.

Adults expressing wakeGD12087 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4pnr-MD237 results in external sensory organs consisting of empty or multiple sockets in 0% or 10-20% of the Scer\GAL4pnr-MD237 expression domain of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of wakeGD12087 and dlg1GD4689 in all neuroblasts under the control of Scer\GAL4insc-Mz1407 causes massive overproliferation of neuroblasts, accompanied by increased mitotic activity.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
CG45058GD12087
CG6954GD12087
wakeGD12087
Name Synonyms
Secondary FlyBase IDs
    References (6)