FlyBase Allele Report: Dmel\SCAR[GD11380]

General Information

Symbol

Dmel\SCAR^GD11380

Species

D. melanogaster

Name

FlyBase ID

FBal0208440

Feature type

allele

Associated gene

Dmel\SCAR

Associated Insertion(s)

Carried in Construct

P{GD11380}

Also Known As

UAS-SCAR RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11380}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11380

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Fereres et al., 2019)

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.UAS

(Fereres et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^sd.PU

(Gohl et al., 2010)

Phenotype Manifest In

follicle cell | somatic clone

(Sarpal et al., 2012)

wing, with Scer\GAL4^sd.PU

(Gohl et al., 2010)

Detailed Description

Statement

Reference

Expression of SCAR^GD11380 under the control of Scer\GAL4^Hml.Δ does not result in any significantly reduced survival when infected with Leishmania amastigotes, as compared to wild type.

(Okuda et al., 2016)

Clonal follicle cells expressing SCAR^GD11380 are apically constricted, and adherens junctions appear jagged between mutant cells and between mutant and wild type cells. The phenotypes are most pronounced in stage 11 or older egg chambers.

(Sarpal et al., 2012)

The wings of flies expressing SCAR^GD11380 under the control of Scer\GAL4^sd.PU are wrinkled.

(Gohl et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in late pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11380

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

SCAR^GD11380/Scer\GAL4^αTub84B.PL is a non-enhancer of abnormal cell migration | oogenesis | somatic clone phenotype of not¹

(Badmos et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/SCAR^GD11380 is a suppressor of decreased cell size | somatic clone phenotype of Dora^A

(Molina-Pelayo et al., 2022)

SCAR^GD11380, Scer\GAL4^ptc.PU is a suppressor of visible | adult stage phenotype of Dora^GD6527, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

SCAR^GD11380/Scer\GAL4^αTub84B.PL is a suppressor | partially of abnormal cell migration | somatic clone | oogenesis phenotype of not¹

(Badmos et al., 2021)

SCAR^GD11380, Scer\GAL4^ap-md544 is a suppressor of increased mortality during development phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

SCAR^GD11380, Scer\GAL4^ap-md544 is a suppressor of partially lethal phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

SCAR^GD11380, Scer\GAL4^ptc-559.1 is a suppressor of increased cell number | larval stage phenotype of Ret^MEN2B.UAS, Scer\GAL4^ptc-559.1

(Fereres et al., 2019)

Scer\GAL4^ptc-559.1/SCAR^GD11380 is a suppressor of increased mortality during development phenotype of Ret^MEN2B.UAS

(Fereres et al., 2019)

Scer\GAL4^ptc-559.1/SCAR^GD11380 is a suppressor of partially lethal - majority die phenotype of Ret^MEN2B.UAS

(Fereres et al., 2019)

SCAR^GD11380, Scer\GAL4^ap-md544 is a suppressor of neoplasia | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

SCAR^GD11380, Scer\GAL4^ap-md544 is a suppressor of increased cell number | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

NOT Suppressor of

Statement

Reference

SCAR^GD11380/Scer\GAL4^αTub84B.PL is a non-suppressor | partially of abnormal cell migration | somatic clone | oogenesis phenotype of not¹

(Badmos et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

SCAR^GD11380, Scer\GAL4^Hml.PU is an enhancer of hemocyte phenotype of Dora^{WT.UAS.Tag:HA}, Scer\GAL4^Hml.PU

(Molina-Pelayo et al., 2022)

SCAR^GD11380, Scer\GAL4^Hml.PU is an enhancer of filopodium | increased number phenotype of Dora^{WT.UAS.Tag:HA}, Scer\GAL4^Hml.PU

(Molina-Pelayo et al., 2022)

NOT Enhancer of

Statement

Reference

SCAR^GD11380/Scer\GAL4^αTub84B.PL is a non-enhancer of border follicle cell | somatic clone phenotype of not¹

(Badmos et al., 2021)

SCAR^GD11380 is a non-enhancer of adherens junction | somatic clone phenotype of α-Cat^GD8808

(Sarpal et al., 2012)

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/SCAR^GD11380 is a suppressor of hemocyte | somatic clone phenotype of Dora^A

(Molina-Pelayo et al., 2022)

SCAR^GD11380, Scer\GAL4^ptc.PU is a suppressor of wing hair phenotype of Dora^GD6527, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

SCAR^GD11380, Scer\GAL4^ptc-559.1 is a suppressor of anterior-posterior compartment boundary of the wing disc phenotype of Ret^MEN2B.UAS, Scer\GAL4^ptc-559.1

(Fereres et al., 2019)

SCAR^GD11380, Scer\GAL4^ap-md544 is a suppressor of wing disc phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

NOT Suppressor of

Statement

Reference

SCAR^GD11380/Scer\GAL4^αTub84B.PL is a non-suppressor of border follicle cell | somatic clone phenotype of not¹

(Badmos et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

All larvae co-expressing psq^KK111691 and Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 during larval stages (using Gal80[ts] for the temporal regulation of expression) wing discs tumors, associated with higher numbers of myoblasts. These phenotypes are partially suppressed by the co-expression of SCAR^GD11380.

(Fereres et al., 2019)

Co-expression of SCAR^GD11380 does not enhance the adherens junction phenotype seen in follicle cell clones expressing α-Cat^GD8808.

(Sarpal et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v21908

w¹¹¹⁸; P{GD11380}v21908/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11380

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

SCAR^GD11380

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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