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General Information
Symbol
Dmel\PtenJF01859
Species
D. melanogaster
Name
FlyBase ID
FBal0219868
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-pten RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of PtenJF01859 under the control of Scer\GAL4e16A results in a significant increase in trichome density in the wing.

Expression of PtenJF01859 in the pupal wing under the control of Scer\GAL80ts.αTub84B and Scer\GAL4en.PU causes cell rearrangement defects where newly formed junctions fail to elongate and become unstable. Compared with wild-type tissues, an excess of short junctions are observed in the mutant tissue. The excess of short junctions observed in the mutant tissue is associated with a failure of junction lengthening during cell rearrangement accompanied by junction instability.

Expression of PtenJF01859 under the control of Scer\GAL4en.PU drastically effects the ridge organization on the adult wing cuticle.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of trblScer\UAS.T:Zzzz\FLAG suppresses the increase in trichome density seen in the wings of flies expressing PtenJF01859 under the control of Scer\GAL4e16A. The resulting flies exhibit a significant decrease in trichome density compared with controls, as is seen in trblScer\UAS.T:Zzzz\FLAG alone.

rok2 clones generated in PtenJF01859-expressing tissue suppresses the effect of the expression of PtenJF01859 under the control of Scer\GAL80ts.αTub84B and Scer\GAL4en.PU on cell packing, namely the excess of short junctions. Despite a slightly higher proportion of non-rearranging junctions (1.15-fold), the rearranging junctions neither produce an excess of short junctions nor fluctuate extensively, but lengthen to produce long cell junctions as observed in wild-type tissue. Furthermore, the packing and cell rearrangement dynamics in the double mutant tissue is similar to the one observed in rok2 single mutant tissue.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
PtenJF01859
Name Synonyms
Secondary FlyBase IDs
    References (9)