Brca2^56E/Brca2^KO third instar larval brain neuroblasts show a small increase in the frequency of chromosomal aberrations, as compared to controls.

Brca2^KO homozygous females crossed to control males lay significantly less eggs than control females; the eggs show abnormal morphology, including egg-shell transparency, round or flattened shape, and fused or no dorsal appendages. Control females crossed to Brca2^KO homozygous males do not show defects in egg production. Intercross of Brca2^KO/+ males and females has no effect on the numbers of eggs or progeny.

Brca2^KO homozygous females show ovary defects, from underdeveloped ovaries (fewer ovarioles, with small, disordered, and misshapen egg chambers, and few mature eggs) to complete ovarian dysgenesis; there is extensive disintegration of egg chambers starting at stage 7, including destruction of cell envelopes, DNA condensation, and extensive apoptosis. Brca2^KO heterozygous females do not show these defects.

In Brca2^KO homozygous males, nearly all testes are moderately-to-severely small and underdeveloped, and lack spermatogenesis stages of elongation, individualization, and coiling; these testis show aberrant DNA location, lack of actin structures, and increased apoptosis. Brca2^KO heterozygous males do not show these defects.

Mutant flies are sensitive to camptothecin, topotecan and to ionising radiation.

Brca2^KO/Brca2^56E larvae are highly sensitive to treatment with X-rays or with methyl methanesulfonate.

Brca2^KO/Brca2^56E mutants show significant decreases in HR-h (homologous recombination using the homologous chromosome) repair in a "Repair Reporter 3" assay when the HR-h pathway is available. Short tract HR-h is decreased 64-fold from wild-type values and long-tract HR-h in decreased 9-fold. There is a significant increase in single-strand annealing and in flanking deletions in the mutant flies compared to controls under these conditions.

Eggs laid by Brca2^KO/Brca2^56E females have a highly penetrant karyosome defect. Some of these eggs are weakly ventralised, having two dorsal appendages that are fused at the base.

Some eggs produced by homozygous females are weakly ventralised, either having two dorsal appendages that are fused at the base or having a single dorsal appendage.

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-enhanceable by PolD3^L2/mus81^Nhe

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-enhanceable by Pif1¹⁶⁷/mus81^Nhe

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-enhanceable by PolD3^L2

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-enhanceable by spn-A³

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-enhanceable by spn-A³

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-enhanceable by spn-A³/PolD3^L2

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-enhanceable by mus81^Nhe

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-enhanceable by mus81^Nhe

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-suppressible by PolD3^L2/mus81^Nhe

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-suppressible by Pif1¹⁶⁷/mus81^Nhe

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-suppressible by PolD3^L2

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-suppressible by spn-A³

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-suppressible by spn-A³

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-suppressible by spn-A³/PolD3^L2

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype, non-suppressible by mus81^Nhe

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype, non-suppressible by mus81^Nhe

Brca2^KO, Pif1¹⁶⁷ has lethal - all die before end of larval stage phenotype

Brca2^KO, PolD3^L2 has lethal - all die before end of larval stage phenotype

Brca2^KO/Brca2^56E, tws⁴³⁰ has lethal - all die before end of first instar larval stage phenotype

Brca2^KO/Brca2^56E has karyosome phenotype, suppressible by mei-P22^unspecified/mei-P22^unspecified

Brca2^KO/Brca2^56E has dorsal appendage phenotype, suppressible by mei-P22^unspecified/mei-P22^unspecified

Brca2^KO/Brca2^56E has karyosome phenotype, suppressible by lok^p6/lok^p6

Brca2^KO/Brca2^56E has dorsal appendage phenotype, suppressible by lok^p6/lok^p6

Brca2^KO/Brca2^56E has karyosome phenotype, non-suppressible by mei-41^D3

Brca2^KO/Brca2^56E has dorsal appendage phenotype, non-suppressible by mei-41^D3

Brca2^KO/Brca2^56E has karyosome phenotype, non-suppressible by mei-41^29D

Brca2^KO/Brca2^56E has dorsal appendage phenotype, non-suppressible by mei-41^29D

Brca2^KO/Brca2^56E is an enhancer of larval brain | third instar larval stage phenotype of aurA⁹⁴⁹

Brca2^KO/Brca2^56E is an enhancer of neuroblast | third instar larval stage phenotype of aurA⁹⁴⁹

Brca2^KO/Brca2^56E is an enhancer of chromosome | third instar larval stage phenotype of aurA⁹⁴⁹

Brca2^KO/Brca2^56E is a suppressor | partially of dorsal appendage phenotype of spn-A^unspecified

Brca2^KO/Brca2^56E is a suppressor of dorsal appendage phenotype of okr^unspecified

Brca2^KO/Brca2^56E is a suppressor of dorsal appendage phenotype of spn-D¹