FlyBase Gene Report: Dmel\Brca2

General Information

Symbol

Dmel\Brca2

Species

D. melanogaster

Name

BRCA2, DNA repair associated

Annotation Symbol

CG30169

Feature Type

protein_coding_gene

FlyBase ID

FBgn0050169

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

BRCA2, DNA repair associated (Brca2) encodes the ortholog of the human BRCA2 gene, which acts as a tumor suppressor. It is involved in double-strand break repair via homologous recombination. During meiosis in females it is involved in DNA repair and in the activation of a meiotic checkpoint. It co-immunoprecipitates with the checkpoint protein encoded by Rad9. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

dmbrca2, Breast cancer 2, early onset homolog

Key Links

Genomic Location

Cytogenetic map

60D4-60D4

Sequence location

2R:24,526,172..24,529,581 [+]

Recombination map

2-107

RefSeq locus

NT_033778 REGION:24526172..24529581

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q27297

(Brough et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in DNA repair

inferred from direct assay

(Brough et al., 2008)

involved_in DNA synthesis involved in double-strand break repair via homologous recombination

inferred from mutant phenotype

(Klovstad et al., 2008)

involved_in double-strand break repair via homologous recombination

inferred from mutant phenotype

(Peretz et al., 2009, Klovstad et al., 2008)

involved_in meiotic DNA repair synthesis involved in reciprocal meiotic recombination

inferred from mutant phenotype

(Klovstad et al., 2008)

involved_in meiotic recombination checkpoint signaling

inferred from genetic interaction with FLYBASE:Hus1-like; FB:FBgn0026417

(Peretz et al., 2009)

inferred from mutant phenotype

(Klovstad et al., 2008)

inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989

(Klovstad et al., 2008)

inferred from genetic interaction with FLYBASE:spn-A; FB:FBgn0003479

(Klovstad et al., 2008)

inferred from genetic interaction with FLYBASE:spn-D; FB:FBgn0003482

(Klovstad et al., 2008)

involved_in response to camptothecin

inferred from mutant phenotype

(Thomas et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in DNA repair

inferred from electronic annotation with InterPro:IPR015525

(InterPro Project Members, 2004-)

involved_in double-strand break repair via homologous recombination

inferred from electronic annotation with InterPro:IPR015525

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Brough et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.

(UniProt, Q9W157)

Summary (Interactive Fly)

Brca2 homolog - plays a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Brca2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W157)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Brca2-RA

FBtr0072302

NM_138081

3291

971

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Brca2-PA

FBpp0072209

108.6

971

5.44

Q9W157

NP_611925

AAF47220

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Rad9 (PubMed:18266476). Interacts with spn-A/Rad51 (PubMed:17822964). Interacts with cyclin CycG (PubMed:22976300).

(UniProt, Q9W157)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W157

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Brca2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Brca2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.54

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Brough et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Brca2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Brca2

View exonic expression by tissue for Dmel\Brca2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0050169

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37916/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050169

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050169

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050169

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30169

Flygut - An atlas of the Drosophila adult midgut

FBgn0050169

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Brca2

Transgenic constructs containing regulatory region of Brca2

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6278

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(2R)Brca2^56E

(Klovstad et al., 2008)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Brca2^GD8853

viable, with Scer\GAL4^Mef2.PR

Brca2^GD8853

viable, with Scer\GAL4^pnr-MD237

Brca2^GD8853

viable (with Brca2^56E)

Brca2^KO

viable (with Brca2^KO)

Brca2^56E

Sterility

Allele

female sterile

Brca2^FA7

female sterile (with Brca2^56E)

Brca2^KO

female sterile (with Brca2^KO)

Brca2^56E

female sterile | recessive

male sterile | recessive

Brca2^KO

Other Phenotypes

Allele

abnormal DNA repair

Brca2^56E

abnormal DNA repair (with Brca2^56E)

Brca2^KO

abnormal DNA repair (with Brca2^KO)

Brca2^56E

abnormal DNA repair | adult stage

Brca2⁴⁷

abnormal size | adult stage | female | recessive

Brca2^KO

abnormal size | adult stage | male | recessive

Brca2^KO

chemical sensitive

chemical sensitive (with Brca2^56E)

Brca2^KO

chemical sensitive (with Brca2^KO)

Brca2^56E

chemical sensitive | recessive

Brca2^56E

decreased fecundity | female | recessive

Brca2^KO

decreased fecundity | male

Brca2^KO

increased cell death | oogenesis

Brca2^KO

increased cell death | spermatogenesis

Brca2^KO

radiation sensitive

Brca2^KO

radiation sensitive (with Brca2^56E)

Brca2^KO

radiation sensitive (with Brca2^KO)

Brca2^56E

radiation sensitive | recessive

Brca2^56E

visible | oogenesis | recessive

Brca2^KO

Phenotype manifest in

Allele

chromosome | third instar larval stage (with Brca2^56E)

Brca2^KO

chromosome | third instar larval stage (with Brca2^KO)

Brca2^56E

dorsal appendage

Brca2^KO

dorsal appendage (with Brca2^56E)

Brca2^KO

dorsal appendage (with Brca2^KO)

Brca2^56E

dorsal appendage | maternal effect (with Brca2^56E)

Brca2^KO

dorsal appendage | maternal effect (with Brca2^KO)

Brca2^56E

egg

Brca2^KO

egg chamber

Brca2^KO

elongation stage spermatid

Brca2^KO

individualization stage spermatid

Brca2^KO

karyosome (with Brca2^56E)

Brca2^KO

karyosome (with Brca2^KO)

Brca2^56E

larval brain | third instar larval stage (with Brca2^56E)

Brca2^KO

larval brain | third instar larval stage (with Brca2^KO)

Brca2^56E

neuroblast | third instar larval stage (with Brca2^56E)

Brca2^KO

neuroblast | third instar larval stage (with Brca2^KO)

Brca2^56E

oocyte

Brca2^KO

ovariole

Brca2^KO

ovary

Brca2^KO

testis

Brca2^KO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\BRCA2

2 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Brca2

2 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Brca2

2 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\brca2

1 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\brca2

2 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007032

2 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\BRCA2(IV)

2 of 13

Yes

Atha\BRCA2B

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Brca2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

ovarian dysgenesis (postulated), BRCA2-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Brca2^KO

model of 46 XX gonadal dysgenesis

CEA

(Weinberg-Shukron et al., 2018)

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

BRCA2; BRCA2 DNA repair associated

model of Fanconi anemia complementation group D1

IEA

(FlyBase, 2019-)

model of medulloblastoma

IEA

(FlyBase, 2019-)

model of nephroblastoma

IEA

(FlyBase, 2019-)

model of breast cancer

IEA

(FlyBase, 2019-)

model of prostate cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Brca2 - CycG

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Nagel et al., 2012)

Brca2 - LBR

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Lam

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, ion exchange chromatography, peptide massfingerprinting, pull down, anti tag western blot

(Kusch, 2015)

Brca2 - Nipped-B

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Nup205

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Nup50

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Nup75

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Ote

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - Rad9

anti tag coimmunoprecipitation, anti tag western blot

(Nagel et al., 2012, Klovstad et al., 2008)

Brca2 - SA1

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - SMC1

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - SMC3

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Brca2 - pds5

ion exchange chromatography, peptide massfingerprinting, anti tag coimmunoprecipitation, western blot, coimmunoprecipitation, pull down, anti tag western blot

(Kusch, 2015)

Brca2 - spn-A

anti tag coimmunoprecipitation, anti tag western blot, ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015, Brough et al., 2008)

Brca2 - vtd

ion exchange chromatography, peptide massfingerprinting

(Kusch, 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Brca2

enhanceable

aurA

(Merigliano et al., 2019)

Brca2

suppressible

lok

(Klovstad et al., 2008)

Brca2

suppressible

mei-P22

(Klovstad et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aurA

enhanceable

Brca2

(Merigliano et al., 2019)

okr

suppressible

Brca2

(Klovstad et al., 2008)

spn-A

suppressible

Brca2

(Klovstad et al., 2008)

spn-D

suppressible

Brca2

(Klovstad et al., 2008)

External Data

Subunit Structure (UniProtKB)

Interacts with Rad9 (PubMed:18266476). Interacts with spn-A/Rad51 (PubMed:17822964). Interacts with cyclin CycG (PubMed:22976300).

(UniProt, Q9W157 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63488

DroID - A comprehensive database of gene and protein interactions.

FBgn0050169

MIST (protein-protein) - An integrated Molecular Interaction Database

37916

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-107

Cytogenetic map

60D4-60D4

Sequence location

2R:24,526,172..24,529,581 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60D4-60D4

Limits computationally determined from genome sequence between P{PZ}bs⁰³²⁶⁷&P{lacW}l(2)k10502^k10502 and P{lacW}Nurf-38^k16102

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016)

2-111.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

13272

y¹ w^67c23; P{SUPor-P}Brca2^KG03961/CyO

NIG-Fly

2RG-0027

y² VhaAC39-1^cho-1 v¹; P{U6-Brca2.NIG.sgRNA}attP40/CyO

VDRC

v105465

P{KK104918}VIE-260B

v39957

w¹¹¹⁸; P{GD8853}v39957

v342588

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02360}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0050169

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM03728

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0050169

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kusch, 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Loss of Brca2 sensitizes cells to DNA damage.

(Brough et al., 2008)

Brca2 is essential for inter-homolog gene conversion but dispensable for single strand annealing repair.

(Brough et al., 2008)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG30169 BcDNA:SD25109

(FlyBase, 1996-)

Source for merge of: CG13583 CG13584

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG13583 and CG13584 merged as CG30169 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG30169 BcDNA:SD25109 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Brca2 CG30169

(Klovstad et al., 2008)

Nomenclature comments

Etymology

Named 'Brca2' after the human homolog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

30169

(Ravi et al., 2009)

BRCA2

(Barclay et al., 2014, Chakraborty, 2013, Nagel et al., 2012, Siddiqui et al., 2012)

BcDNA:SD25109

Brca2

(Molano-Fernández et al., 2025, Bilder et al., 2021, Carvajal-Garcia et al., 2021, Koval et al., 2020, Nakajima et al., 2020, Robinson et al., 2020, Khan et al., 2019, Misulovin et al., 2018, Holsclaw and Sekelsky, 2017, John et al., 2016, Shaposhnikov et al., 2015, Bolterstein et al., 2014, Lee et al., 2014, Thomas and McVey, 2014.3.1, Langley et al., 2012)

CG13583

CG13584

CG30169

(National Institute of Genetics Fly Stocks, 2022-, Azad et al., 2012, Bennett and Noor, 2009, Keleman et al., 2009.8.5, Brough et al., 2008, Klovstad et al., 2008)

Dmbrca2

(Weinberg-Shukron et al., 2018, Brough et al., 2008)

brca

(Merigliano et al., 2017)

brca2

(Kocak et al., 2019, Merigliano et al., 2019, Merigliano et al., 2017, Alexander et al., 2016, Alexander et al., 2015, Thomas et al., 2013, Nagel et al., 2012, Bennett and Noor, 2009, Peretz et al., 2009, Klovstad et al., 2008)

dmbrca2

(Bennett et al., 2010, Bennett and Noor, 2009, Brough et al., 2008)

Name Synonyms

BRCA2, DNA repair associated

Breast cancer 2 early onset homolog

(Lee et al., 2014)

Breast cancer 2, early onset homolog

(John et al., 2016)

CG30169

Secondary FlyBase IDs

FBgn0035017
FBgn0035018
FBgn0062848

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37916

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W157

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W157

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W157

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0050169

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37916/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050169

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050169

FlyMine - An integrated database for Drosophila genomics

FBgn0050169

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30169

MARRVEL_MODEL - MARRVEL (model organism gene)

37916

Linkouts

BioGRID - A database of protein and genetic interactions.

63488

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0050169

DroID - A comprehensive database of gene and protein interactions.

FBgn0050169

DRSC - Results frm RNAi screens

FBgn0050169

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Brca2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050169

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0050169

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30169

Flygut - An atlas of the Drosophila adult midgut

FBgn0050169

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

37916

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-0.54

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