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General Information
Symbol
Dmel\Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0221612
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
FLAG-FlAsH-HA-DRP1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

9.35kb genomic fragment containing Drp1, which contains a "FLAG-FlAsH-HA" triple tag (Tag:FLAG, Tag:CALI(TC) and Tag:HA) after the start codon.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 in an otherwise wild-type background has no effect on mitochondrial network morphology in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrion & indirect flight muscle phenotype of Pink1B9

Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrial inner membrane & indirect flight muscle phenotype of Pink1B9

Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1B9

NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 results in partial rescue of the thoracic indentation and impaired flight phenotypes of Pink1B9 hemizygous mutants.

The abnormal wing posture phenotype and the abnormal morphology of the indirect flight muscles and their mitochondria which is seen in Pink1B9 flies is suppressed by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in Pink1B9 animals is suppressed by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing Pink1Scer\UAS.cYa under the control of Scer\GAL4ple.PF is not modified by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

Xenogenetic Interactions
Statement
Reference

Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 has no effect on the increase in mitochondria length or neurotoxicity seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1
Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (9)