FB2026_02 , released June 18, 2026
Allele: Dmel\Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
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General Information
Symbol
Dmel\Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0221612
Feature type
allele
Associated gene
Dmel\Drp1
Associated Insertion(s)
Carried in Construct
P{FLAG-FlAsH-HA-Drp1}
Also Known As
FLAG-FlAsH-HA-DRP1
Key Links
Transgenic product class
genomic_DNA
(Verstreken et al., 2005)
wild_type
(Verstreken et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Verstreken et al., 2005)
wild_type
(Verstreken et al., 2005)
Mutagen
in vitro construct
(Verstreken et al., 2005)
Progenitor genotype
Carried in construct
P{FLAG-FlAsH-HA-Drp1}
Cytology
Description

9.35kb genomic fragment containing Drp1, which contains a "FLAG-FlAsH-HA" triple tag (Tag:FLAG, Tag:CALI(TC) and Tag:HA) after the start codon.

(Verstreken et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Drp1
Encoded product / tool
Drp1
Tagged with
Tag:CALI(TC)
Tag:FLAG
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Poole et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 in an otherwise wild-type background has no effect on mitochondrial network morphology in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster.

      (Yang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor | partially of adult thorax phenotype of Pink1B9

      (Poole et al., 2008)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1B9

      (Yang et al., 2008)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of wing phenotype of Pink1B9

      (Yang et al., 2008)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of indirect flight muscle cell phenotype of Pink1B9

      (Yang et al., 2008)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrion & indirect flight muscle phenotype of Pink1B9

      (Yang et al., 2008)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a suppressor of mitochondrial inner membrane & indirect flight muscle phenotype of Pink1B9

      (Yang et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a non-suppressor of adult brain phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

      (Duboff et al., 2012)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a non-suppressor of mitochondrion phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

      (Duboff et al., 2012)

      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA is a non-suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1UAS.cYa, Scer\GAL4ple.PF

      (Yang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 results in partial rescue of the thoracic indentation and impaired flight phenotypes of Pink1B9 hemizygous mutants.

      (Poole et al., 2008)

      The abnormal wing posture phenotype and the abnormal morphology of the indirect flight muscles and their mitochondria which is seen in Pink1B9 flies is suppressed by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

      The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in Pink1B9 animals is suppressed by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

      The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing Pink1Scer\UAS.cYa under the control of Scer\GAL4ple.PF is not modified by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1.

      (Yang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 has no effect on the increase in mitochondria length or neurotoxicity seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU.

      (Duboff et al., 2012)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1
      Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
      drp1TGt
      (Poole et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)