Expression of stj^KK101267 under the control of Scer\GAL4^VGlut-OK371 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the muscle EPSPs from muscle 10 following extracellular stimulation of the motor nerve.

Mosaic expression of stj^KK101267 under the control of Scer\GAL4^eve.RN2 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the Ca2[+] current amplitude in larval crawling motor neurons.

Expression of stj^KK101267 under the control of Scer\GAL4^GMR23H06 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the high voltage activated Ca2[+] current amplitude in pupal motor neurons, and a reduction in the sustained high voltage activated Ca2[+] current amplitude and transient low voltage activated Ca2[+] current amplitude in adult motor neurons.

Expression of stj^KK101267 under the control of Scer\GAL4^Toll-6-D42 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to smaller action potential width in pupal DLM motor neurons. It also leads to decrease in the total dendritic length and in the number of branches of adult DLM.

Expression of stj^KK101267 under the control of Scer\GAL4^GMR23H06 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the dendritic and axonal Ca2[+] signal amplitudes induced upon firing by somatic ramp current injection in pupal dorsolongitudinal wing depressor muscle motor neurons.

Expression of stj^KK101267 under the control of Scer\GAL4^ppk.PG leads to significantly slower heat nociception in third instar larvae; significant suppression of noxious escape behavior (jumping) in response to heated surface; and complete suppression of neuropathic sensitization after injury in adults when compared to controls.

Adults expressing stj^KK101267 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show reduced avoidance of noxious temperature (46[o]C) compared to control flies. The kinetics of temperature induced paralysis at 46[o]C in these flies is comparable to that of control flies.

Scer\GAL4^Toll-6-D42, stj^KK101267 has abnormal neurophysiology | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^Toll-6-D42

Scer\GAL4^GMR23H06, stj^KK101267 has abnormal neurophysiology | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^GMR23H06

Scer\GAL4^Toll-6-D42, stj^KK101267 has muscle cell of leg depressor muscle | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^Toll-6-D42

Scer\GAL4^Toll-6-D42, stj^KK101267 has motor neuron | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^Toll-6-D42

Scer\GAL4^GMR23H06, stj^KK101267 has axon | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^GMR23H06

Scer\GAL4^GMR23H06, stj^KK101267 has motor neuron | P-stage phenotype, suppressible | partially by stol^KK106795/Scer\GAL4^GMR23H06