FlyBase Allele Report: Dmel\Sec15[KK101708]

General Information

Symbol

Dmel\Sec15^KK101708

Species

D. melanogaster

Name

FlyBase ID

FBal0231433

Feature type

allele

Associated gene

Dmel\Sec15

Associated Insertion(s)

Carried in Construct

P{KK101708}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101708}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101708

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS

(Chabu and Xu, 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Sec15^KK101708 driven by Scer\GAL4^phm.PO leads to developmental delay/arrest at the larval stage.

(Yamanaka et al., 2015)

Cell proliferation is not affected in eye-antennal disc clones expressing Sec15^KK101708 under the control of Scer\GAL4^Act.PU.

(Chabu and Xu, 2014)

Temperature-induced expression of sec15^KK101708 starting at the the third instar stage under the control of both Scer\GAL4^dpp.blk1 and Scer\GAL80^ts.αTub84B induces defects in trichome development in pupal wings.

(Gault et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neurophysiology | larval stage phenotype, non-enhanceable by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by wit^B11/wit^A12

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neurophysiology | larval stage phenotype, non-suppressible by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Enhancer of

Statement

Reference

Sec15^KK101708, Scer\GAL4^elav.PU is an enhancer of abnormal neuroanatomy | larval stage phenotype of Rab3^KK108633, Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU/Sec15^KK101708 is an enhancer of abnormal neuroanatomy | larval stage phenotype of Rab3^rup

(Kang et al., 2024)

Suppressor of

Statement

Reference

Sec15^KK101708, Scer\GAL4^Act.PU is a suppressor | partially of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified

(Chabu and Xu, 2014)

Sec15^KK101708, Scer\GAL4^Act.PU is a suppressor | partially of lethal - all die before end of pupal stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified

(Chabu and Xu, 2014)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has NMJ bouton | larval stage | increased number phenotype, non-enhanceable by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has embryonic/larval neuromuscular junction | larval stage phenotype, non-enhanceable by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has presynaptic active zone | larval stage phenotype, non-enhanceable by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has type I bouton | larval stage phenotype, non-enhanceable by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has NMJ bouton | increased number | larval stage phenotype, suppressible | partially by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by wit^B11/wit^A12

(Kang et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Sec15^KK101708 has presynaptic active zone | larval stage phenotype, non-suppressible by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has type I bouton | larval stage phenotype, non-suppressible by wit^JF01969/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has NMJ bouton | increased number | larval stage phenotype, non-suppressible by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU, Sec15^KK101708 has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by sax^JF03431/Scer\GAL4^elav.PU

(Kang et al., 2024)

Enhancer of

Statement

Reference

Sec15^KK101708, Scer\GAL4^elav.PU is an enhancer of presynaptic active zone | larval stage phenotype of Rab3^KK108633, Scer\GAL4^elav.PU

(Kang et al., 2024)

Sec15^KK101708, Scer\GAL4^elav.PU is an enhancer of type I bouton | larval stage phenotype of Rab3^KK108633, Scer\GAL4^elav.PU

(Kang et al., 2024)

Scer\GAL4^elav.PU/Sec15^KK101708 is an enhancer of presynaptic active zone | larval stage phenotype of Rab3^rup

(Kang et al., 2024)

Scer\GAL4^elav.PU/Sec15^KK101708 is an enhancer of type I bouton | larval stage phenotype of Rab3^rup

(Kang et al., 2024)

Suppressor of

Statement

Reference

Sec15^KK101708, Scer\GAL4^Act.PU is a suppressor | partially of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified

(Chabu and Xu, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sec15^KK101708 suppresses the overgrowth and ventral nerve cord invasion seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in a scrib^unspecified mutant background.

(Chabu and Xu, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sec15^KK101708 is rescued by Scer\GAL4^elav.PU/Sec15^UAS.RR

(Kang et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105126

P{KK101708}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sec15^KK101708

sec15^KK101708

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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