FlyBase Allele Report: Dmel\Dsor1[KK102276]

General Information

Symbol

Dmel\Dsor1^KK102276

Species

D. melanogaster

Name

FlyBase ID

FBal0231704

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

P{KK102276}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102276}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102276

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

ameliorates colorectal cancer

modeled by SH3PX1^JF02730

(Zhang et al., 2019)

ameliorates hematologic cancer

modeled by mxc¹

(Kurihara et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^Ilp2.PR-mediated expression results in a significant reduction in the body weight of emerging adults compared to controls.

(Hasygar and Hietakangas, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dsor1^KK102276, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Dsor1^KK102276, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Atg8a^HMS01328, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Dsor1^KK102276, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^esg.PU, Syx17^JF01937

(Zhang et al., 2019)

Scer\GAL4^Ras64B.PW/Dsor1^KK102276 is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP0001/Dsor1^KK102276 is a non-suppressor of increased occurrence of cell division | recessive | adult stage phenotype of SH3PX1^d1

(Zhang et al., 2019)

Other

Statement

Reference

Dsor1^KK102276, Nf1^E2, Scer\GAL4^repo has lethal phenotype

(Walker et al., 2013)

Dsor1^KK102276, Nf1^E2, Scer\GAL4^C23 has lethal phenotype

(Walker et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dsor1^KK102276, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium phenotype of Atg8a^HMS01328, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Dsor1^KK102276, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^esg.PU, Syx17^JF01937

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^NP0001/Dsor1^KK102276 is a non-suppressor of adult midgut epithelium phenotype of SH3PX1^d1

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Dsor1^KK102276 under the control of Scer\GAL4^Ras64B.PW at 18[o]C suppresses the reduced pupal length phenotype seen in Nf1^E2 animals.

(Walker et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107276

P{KK102276}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dsor1^KK102276

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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