FlyBase Allele Report: Dmel\imd[KK109863]

General Information

Symbol

Dmel\imd^KK109863

Species

D. melanogaster

Name

FlyBase ID

FBal0236524

Feature type

allele

Associated gene

Dmel\imd

Associated Insertion(s)

Carried in Construct

P{KK109863}

Also Known As

UAS-imd RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109863}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109863

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by dlg1^A40.2

(Parvy et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^yolk

(Longworth et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of imd^KK109863 RNAi under the control Scer\GAL4^Hml.Δ driver does not rescue the lowered survival of adult flies on lard-supplemented diet compared to controls.

(Woodcock et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

imd^KK109863/Scer\GAL4^btl.PS is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/imd^KK109863 is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB, imd^KK109863, Def^UAS.cTa is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Suppressor of

Statement

Reference

imd^KK109863/Scer\GAL4^btl.PS is a suppressor of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/imd^KK109863 is a suppressor of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB, imd^KK109863, Def^UAS.cTa is a suppressor | partially of increased cell death | larval stage phenotype of dlg1^A40.2

(Parvy et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^C587/imd^KK109863 is a non-suppressor of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

imd^KK109863/Scer\GAL4^btl.PS is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/imd^KK109863 is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB, imd^KK109863, Def^UAS.cTa is an enhancer of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Suppressor of

Statement

Reference

imd^KK109863/Scer\GAL4^btl.PS is a suppressor of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB/imd^KK109863 is a suppressor of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

Scer\GAL4^apolpp.PB, imd^KK109863, Def^UAS.cTa is a suppressor | partially of wing disc phenotype of dlg1^A40.2

(Parvy et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^C587/imd^KK109863 is a non-suppressor of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of imd^KK109863 under the control of Scer\GAL4^btl.PS or Scer\GAL4^apolpp.PB enhances the tumor phenotype of dlg1^A40.2 wing discs, while suppressing the associated apoptosis (Dcp1 staining).

Scer\GAL4^apolpp.PB-driven expression of Def^UAS.cTa in imd^KK109863, dlg1^A40.2 double mutants partially re-establishes the original dlg1^A40.2 phenotypes.

(Parvy et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101834

P{KK109863}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

imd^KK109863

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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