FlyBase Allele Report: Dmel\lola[KK110256]

General Information

Symbol

Dmel\lola^KK110256

Species

D. melanogaster

Name

FlyBase ID

FBal0236738

Feature type

allele

Associated gene

Dmel\lola

Associated Insertion(s)

Carried in Construct

P{KK110256}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK110256}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK110256

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates retinitis pigmentosa

modeled by ninaE^G69D.UAS

(Chow et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Hattori et al., 2013, Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

abnormal size, with Scer\GAL4^en-e16E

(Djiane et al., 2013)

lethal, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaD | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaD, with Scer\GAL4²²¹

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹

(Iyer et al., 2013)

larval ventral multidendritic neuron vdaB, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

wing | posterior, with Scer\GAL4^en-e16E

(Djiane et al., 2013)

Detailed Description

Statement

Reference

Expression of lola^KK110256 under the control of Scer\GAL4^GMR.PF has no effect on the adult eye morphology.

(Chow et al., 2016)

Expression of lola^KK110256 under the control of Scer\GAL4^Bx-MS1096 has no effect on male wing size or patterning.

Expression of lola^KK110256 under the control of Scer\GAL4^Bx-MS1096 has no effect on female wing size or patterning.

(Schertel et al., 2015)

Scer\GAL4^en-e16E-mediated expression results in a moderate reduction in size of the posterior compartment of the adult wing.

(Djiane et al., 2013)

The expression of lola^KK110256 under the control of Scer\GAL4²²¹, in combination with Dicer-2 for efficient RNAi, results in third instar larval class I abdominal dorsal multidendritic neurons ddaD and ddaE exhibiting a significant decrease in the number of dendrite branch terminals, as compared to controls.

Expressing lola^KK110256 under the control of Scer\GAL4^ppk.PG, in combination with Dicer-2 for efficient RNAi, results in third instar larval class IV abdominal dorsal multidendritic neurons ddaC exhibiting dendrite branch terminals of similar number but of significantly lower average length, as compared to controls.

(Hattori et al., 2013)

Expression of lola^KK110256 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls. Dendritic phenotypes are also seen in ddaE neurons. No defects are seen in vpda neurons.

Expression of lola^KK110256 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC, v'ada and vdaB neurons. The total number of dendritic branches is also reduced in ddaC and vdaB neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lola^KK110256/Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

lola^KK110256/Scer\GAL4^GMR.PF is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Suppressor of

Statement

Reference

lola^KK110256, Scer\GAL4^ptc-559.1 is a suppressor | partially of hyperplasia phenotype of N^UAS.icd, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

lola^KK110256/Scer\GAL4²²¹ is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

lola^KK110256/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Suppressor of

Statement

Reference

lola^KK110256/Scer\GAL4²²¹ is a suppressor of abdominal dorsal multidendritic neuron ddaD | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

lola^KK110256/Scer\GAL4²²¹ is a suppressor of abdominal dorsal multidendritic neuron ddaE | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

lola^KK110256/Scer\GAL4²²¹ is a suppressor of dendritic tree | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye phenotype characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced further by co-expression of lola^KK110256.

(Chow et al., 2016)

The increased number of dendrite terminals in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons expressing kn^{Scer\UAS.cHa.T:Ivir\HA1} under the control of Scer\GAL4²²¹ is fully suppressed by co-expressing lola^KK110256.

(Hattori et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101925

P{KK110256}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lola^KK110256

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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