FlyBase Allele Report: Dmel\spz[KK112908]

General Information

Symbol

Dmel\spz^KK112908

Species

D. melanogaster

Name

FlyBase ID

FBal0238478

Feature type

allele

Associated gene

Dmel\spz

Associated Insertion(s)

Carried in Construct

P{KK112908}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112908}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112908

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^r4

(Liu et al., 2016)

abnormal immune response | adult stage, with Scer\GAL4^yolk

(Liu et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of spz^KK112908 driven in the fat body of male flies by Scer\GAL4^r4 (or driven by Scer\GAL4^yolk in female fat bodies) significantly decreases survival of flies in response to Gram-positive bacteria (Staphylococcus aureus or Enterococcus faecalis) and a fungus (Aspergillus fumigatus), compared to controls. Bacterial load (measured as colony forming units 24hr post infection) of S. aureus significantly increases in adult flies, compared to controls.

(Liu et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

spz^KK112908/Scer\GAL4^Hml.Δ is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

spz^KK112908/Scer\GAL4^He.PZ is an enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, spz^KK112908 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^He.PZ, dlg1^A40.2, spz^KK112908 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

spz^KK112908/Scer\GAL4^Hml.Δ is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

spz^KK112908/Scer\GAL4^He.PZ is an enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, spz^KK112908 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^He.PZ, dlg1^A40.2, spz^KK112908 has wing disc phenotype

(Parisi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is virtually abrogated by the expression of spz^KK112908 under the control of either Scer\GAL4^He.PZ or Scer\GAL4^Hml.Δ.

(Parisi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105017

P{KK112908}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spz^KK112908

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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