FlyBase Allele Report: Dmel\Traf6[dsRNA.UAS]

General Information

Symbol

Dmel\Traf6^dsRNA.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0239951

Feature type

allele

Associated gene

Dmel\Traf6

Associated Insertion(s)

Carried in Construct

P{UAS-Traf6.IR}

Also Known As

UAS-dTRAF2-IR

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Igaki et al., 2006)

in vitro construct - RNAi

(Igaki et al., 2006)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-Traf6.IR}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive Traf6 coding sequences in an inverted repeat to allow cell-targeted generation of dsRNA for RNAi knockdown experiments.

(Igaki et al., 2006)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Traf6

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Igaki et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Traf6^{dsRNA.Scer\UAS} in the eye under the control of Scer\GAL4^GMR.PF does not results in any significant phenotype.

(Ma et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^bbg-C96/Traf6^dsRNA.UAS is a suppressor | partially of visible phenotype of Scer\GAL4^bbg-C96, dx^UAS.Tag:FLAG, krz^UAS.Tag:HA

(Mishra et al., 2014)

Scer\GAL4^ptc-559.1/Traf6^dsRNA.UAS is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, Uev1A^UAS.cMa, ben^UAS.cUa

(Ma et al., 2013)

Traf6^dsRNA.UAS, Scer\GAL4^pnr-MD237 is a suppressor of visible phenotype of CYLD^UAS.cXa, Scer\GAL4^pnr-MD237

(Xue et al., 2007)

Scer\GAL4^GMR.PF/Traf6^dsRNA.UAS is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

Traf6^dsRNA.UAS, Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI is a suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, l(2)gl⁴

(Igaki et al., 2006)

NOT Suppressor of

Statement

Reference

Traf6^dsRNA.UAS/Scer\GAL4^ptc.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^ptc.PU, fmt^GD6928

(Ma et al., 2017)

Scer\GAL4^hs.2sev/Traf6^dsRNA.UAS is a non-suppressor of visible phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Traf6^dsRNA.UAS, Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI is a non-suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, l(2)gl⁴

(Igaki et al., 2006)

Other

Statement

Reference

Scer\GAL4^ptc-559.1, Traf6^dsRNA.UAS, Uev1A^UAS.cMa, ben^UAS.cUa has visible phenotype

(Ma et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^bbg-C96/Traf6^dsRNA.UAS is a suppressor | partially of wing phenotype of Scer\GAL4^bbg-C96, dx^UAS.Tag:FLAG, krz^UAS.Tag:HA

(Mishra et al., 2014)

Scer\GAL4^ptc-559.1/Traf6^dsRNA.UAS is a suppressor of anterior crossvein phenotype of Scer\GAL4^ptc-559.1, Uev1A^UAS.cMa, ben^UAS.cUa

(Ma et al., 2013)

Traf6^dsRNA.UAS, Scer\GAL4^pnr-MD237 is a suppressor of scutellum phenotype of CYLD^UAS.cXa, Scer\GAL4^pnr-MD237

(Xue et al., 2007)

Scer\GAL4^GMR.PF/Traf6^dsRNA.UAS is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

NOT Suppressor of

Statement

Reference

Traf6^dsRNA.UAS/Scer\GAL4^ptc.PU is a non-suppressor of anterior crossvein phenotype of Scer\GAL4^ptc.PU, fmt^GD6928

(Ma et al., 2017)

Scer\GAL4^hs.2sev/Traf6^dsRNA.UAS is a non-suppressor of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Other

Statement

Reference

Scer\GAL4^ptc-559.1, Traf6^dsRNA.UAS, Uev1A^UAS.cMa, ben^UAS.cUa has eye phenotype

(Ma et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The partial or complete loss of the wing anterior crossvein in flies expressing fmt^GD6928 under the control of Scer\GAL4^ptc.PU is not suppressed by co-expression of Traf6^{dsRNA.Scer\UAS}.

(Ma et al., 2017)

Expression of Traf6^{dsRNA.Scer\UAS} partially suppresses the wing nicking phenotype seen when krz^{Scer\UAS.T:Ivir\HA1} and dx^{Scer\UAS.T:Zzzz\FLAG} are expressed under the control of Scer\GAL4^bbg-C96. The resulting flies exhibit loss of L4 vein material.

(Mishra et al., 2014)

Expression of Traf6^{dsRNA.Scer\UAS} suppresses the anterior crossvein loss seen when Uev1A^Scer\UAS.cMa and ben^Scer\UAS.cUa are expressed under the control of Scer\GAL4^ptc-559.1.

Co-expression of Uev1A^Scer\UAS.cMa, ben^Scer\UAS.cUa and Traf6^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in rough eye with fused ommatidia.

(Ma et al., 2013)

Expression of Traf6^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act.PU in the cells surrounding scrib¹ clones in the eye-antennal disc significantly suppresses the elimination of the mutant scrib¹ clones compared to that seen when the cells surrounding the clone are wild type.

(Ohsawa et al., 2011)

The small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF is strongly suppressed by co-expression of Traf6^{dsRNA.Scer\UAS}.

Co-expression of Traf6^{dsRNA.Scer\UAS} has no effect on the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

Co-expression of Traf6^{dsRNA.Scer\UAS} fully suppresses the reduced scutellum phenotype caused by expression of CYLD^Scer\UAS.cXa under the control of Scer\GAL4^pnr-MD237.

(Xue et al., 2007)

Expression of Traf6^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system strongly suppresses metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

(Igaki et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Traf6^{dsRNA.Scer\UAS}

Traf6^dsRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (8)

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