FlyBase Allele Report: Dmel\Sec15[JF02649]

General Information

Symbol

Dmel\Sec15^JF02649

Species

D. melanogaster

Name

FlyBase ID

FBal0242238

Feature type

allele

Associated gene

Dmel\Sec15

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02649}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02649}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02649

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | larval stage, with Scer\GAL4^Tub.PU

(Kakade et al., 2025)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

abnormal neurophysiology | larval stage, with Scer\GAL4^elav.PU

(Kang et al., 2024)

decreased body size | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

lethal, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

visible | larval stage, with Scer\GAL4^grh.D4

(Wingen et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Animals expressing Sec15^JF02649 under the control of Scer\GAL4^grh.D4 are lethal, show defects in larval dorsal trunk elongation (resulting in internalization of posterior spiracles into the body cavity) and the larvae are smaller than age-matched controls.

(Wingen et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sec15^JF02649, Scer\GAL4^elav.PU is an enhancer of abnormal neuroanatomy | larval stage phenotype of Rab3^KK108633, Scer\GAL4^elav.PU

(Kang et al., 2024)

Sec15^JF02649, Scer\GAL4^elav.PU is an enhancer of paralytic | adult stage | heat sensitive phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU