FlyBase Allele Report: Dmel\kermit[ex31]

General Information

Symbol

Dmel\kermit^ex31

Species

D. melanogaster

Name

FlyBase ID

FBal0246013

Feature type

allele

Associated gene

Dmel\kermit

Associated Insertion(s)

Carried in Construct

Also Known As

dGIPC^ex31

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Djiane and Mlodzik, 2010)

Progenitor genotype

P{EP}Lpin^EP2431

(Djiane and Mlodzik, 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the kermit transcription unit (including the entire coding region), but does not affect the CG8709 gene.

(Djiane and Mlodzik, 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:8,146,023..8,149,594 [-]

Comment:

Approximate endpoints of deletion resulting from the imprecise excision of P{EP}Lpin^EP2431. One endpoint is in the insertion. The other endpoint was estimated from an R5 coordinate scale and converted to R6 coordinates.

(Djiane and Mlodzik, 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage (with Df(2R)ED1725)

(Chak and Kolodkin, 2014)

abnormal neuroanatomy | embryonic stage (with Df(2R)Exel7095)

(Chak and Kolodkin, 2014)

abnormal neuroanatomy | embryonic stage | semidominant

(Chak and Kolodkin, 2014)

viable

(Djiane and Mlodzik, 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

kermit^ex31/kermit^ex31, kermit^ex31/Df(2R)Exel7095 and kermit^ex31/Df(2R)ED1725 embryos exhibit significant numbers of abnormal motor axon pathways in both ISNb and SNa motor neurons. kermit^ex31/+ embryos exhibit a small increase in abnormal motor axon pathways in both ISNb and SNa motor neurons as compared to wild-type.

(Chak and Kolodkin, 2014)

Homozygous clones do not result in wing hair defects.

(Djiane and Mlodzik, 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

kermit^ex31 has abnormal neuroanatomy | embryonic stage | semidominant phenotype, enhanceable by Df(4)C3/+

(Chak and Kolodkin, 2014)

kermit^ex31 has abnormal neuroanatomy | embryonic stage | semidominant phenotype, enhanceable by Gyc76C[+]/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has abnormal neuroanatomy | embryonic stage | semidominant phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Chak and Kolodkin, 2014)

NOT Enhanced by

Statement

Reference

kermit^ex31 has abnormal neuroanatomy | embryonic stage | semidominant phenotype, non-enhanceable by Gyc76C^KG03723ex173/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

Suppressor of

Statement

Reference

kermit^ex31/kermit[+] is a suppressor | partially of abnormal planar polarity phenotype of Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

kermit^ex31 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by Gyc76C[+]/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has larval segmental nerve branch SNa of A1-7 | embryonic stage phenotype, enhanceable by Gyc76C[+]/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has axon | embryonic stage phenotype, enhanceable by Df(4)C3/+

(Chak and Kolodkin, 2014)

kermit^ex31 has axon | embryonic stage phenotype, enhanceable by Gyc76C[+]/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Chak and Kolodkin, 2014)

kermit^ex31 has larval segmental nerve branch SNa of A1-7 | embryonic stage phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Chak and Kolodkin, 2014)

kermit^ex31 has axon | embryonic stage phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Chak and Kolodkin, 2014)

kermit^ex31 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by Df(4)C3/+

(Chak and Kolodkin, 2014)

kermit^ex31 has larval segmental nerve branch SNa of A1-7 | embryonic stage phenotype, enhanceable by Df(4)C3/+

(Chak and Kolodkin, 2014)

NOT Enhanced by

Statement

Reference

kermit^ex31 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, non-enhanceable by Gyc76C^KG03723ex173/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has larval segmental nerve branch SNa of A1-7 | embryonic stage phenotype, non-enhanceable by Gyc76C^KG03723ex173/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

kermit^ex31 has axon | embryonic stage phenotype, non-enhanceable by Gyc76C^KG03723ex173/Gyc76C^KG03723ex173

(Chak and Kolodkin, 2014)

Suppressor of

Statement

Reference

kermit^ex31/kermit[+] is a suppressor | partially of wing hair | increased number phenotype of Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

kermit^ex31/+, Gyc76C^KG03723ex173/+ double mutants, kermit^ex31/+, Sema-1a^k13702/+ double mutants, and kermit^ex31/+, Df(4)C3/+ double mutants exhibit an increased number of defects in both ISNb and SNa motor neuron axon pathways as compared to kermit^ex31/+ mutant embryos.

kermit^ex31/kermit^ex31, Gyc76C^KG03723ex173/Gyc76C^KG03723ex173 double mutant embryos exhibit a similar number of defects in ISNb motor neuron pathways as compared to kermit^ex31/kermit^ex31 or Gyc76C^KG03723ex173/Gyc76C^KG03723ex173 single mutant embryos, and a similar number of defects in SNa motor neuron pathways as compared to kermit^ex31/kermit^ex31 single mutant embryos.

(Chak and Kolodkin, 2014)

The multiple wing hair phenotype seen in flies expressing Gαo^GD8640 under the control of Scer\GAL4^Bx-MS1096 is partially suppressed if they are heterozygous for kermit^ex31.

(Lin and Katanaev, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

kermit^ex31 is partially rescued by Scer\GAL4^elav.PU/kermit^UAS.Tag:HA

(Chak and Kolodkin, 2014)

kermit^ex31 is partially rescued by kermit^UAS.Tag:HA/Scer\GAL4^sca-537.4

(Chak and Kolodkin, 2014)

kermit^ex31 is partially rescued by Scer\GAL4^VGlut1-OK371/kermit^UAS.Tag:HA

(Chak and Kolodkin, 2014)

Not rescued by

kermit^ex31 is not rescued by kermit^UAS.Tag:HA/Scer\GAL4^repo

(Chak and Kolodkin, 2014)

kermit^ex31 is not rescued by kermit^UAS.Tag:HA/Scer\GAL4^sim.PS

(Chak and Kolodkin, 2014)

Comments

Expression of kermit^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU or Scer\GAL4^sca-537.4 partially rescues the ISNb and SNa motor axon guidance defects of kermit^ex31/kermit^ex31 embryos.

Expression of kermit^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^repo or Scer\GAL4^sim.PS fails to significantly rescue the ISNb and SNa motor axon guidance defects of kermit^ex31/kermit^ex31 embryos.

Expression of kermit^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371 significantly rescues the ISNb, but not SNa, motor axon guidance defects of kermit^ex31/kermit^ex31 embryos.

(Chak and Kolodkin, 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dGIPC^ex31

(Chak and Kolodkin, 2014, Djiane and Mlodzik, 2010)

kermit^ex31

(Gandhi et al., 2025, Lin and Katanaev, 2013)

Name Synonyms

Secondary FlyBase IDs

References (4)

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