FlyBase Allele Report: Dmel\ref(2)P[HMS00551]

General Information

Symbol

Dmel\ref(2)P^HMS00551

Species

D. melanogaster

Name

FlyBase ID

FBal0263216

Feature type

allele

Associated gene

Dmel\ref(2)P

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00551}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00551}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00551

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset

CEC

(Hurley and Staveley, 2021)

CEA

(Hurley and Staveley, 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

modeled by Zzzz\GGGGCC^36.UAS

(Cunningham et al., 2020)

modeled by Zzzz\GGGGCC^{44.LDS.UAS.GR-GFP}

(Cunningham et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^hs.PB

(Liu et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing ref(2)P^HMS00551 under the control of Scer\GAL4^hs.PB infected with ZIKV present an increased viral load in the head, as compared to infected controls.

(Liu et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ref(2)P^HMS00551/Scer\GAL4^GMR.PFa is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

ref(2)P^HMS00551/Scer\GAL4^GMR.PFa is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

Scer\GAL4^{elav.Switch.PO}/ref(2)P^HMS00551 is an enhancer of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

NOT Enhancer of

Statement

Reference

ref(2)P^HMS00551, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

ref(2)P^HMS00551, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

ref(2)P^HMS00551/Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK} is an enhancer of mitochondrion | adult stage phenotype of Scer\GAL4^Mef2.PR, park^HMS01800

(Gumeni et al., 2021)

ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK} is an enhancer of adult somatic muscle cell phenotype of Scer\GAL4^Mef2.PR, park^HMS01800

(Gumeni et al., 2021)

NOT Enhancer of

Statement

Reference

ref(2)P^HMS00551, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK} is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^HMC04160, Scer\GAL4^Mef2.PR

(Gumeni et al., 2021)

ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK} is a non-enhancer of adult somatic muscle cell phenotype of Pink1^HMC04160, Scer\GAL4^Mef2.PR

(Gumeni et al., 2021)

Suppressor of

Statement

Reference

ref(2)P^HMS00551, Scer\GAL4^{αTub84B.Switch.PK}, cnc^UAS.cSa is a suppressor of mitochondrion | adult stage phenotype of Pink1^HMC04160, Scer\GAL4^Mef2.PR

(Gumeni et al., 2021)

ref(2)P^HMS00551, Scer\GAL4^{αTub84B.Switch.PK}, cnc^UAS.cSa is a suppressor of adult somatic muscle cell phenotype of Pink1^HMC04160, Scer\GAL4^Mef2.PR

(Gumeni et al., 2021)

ref(2)P^HMS00551, Scer\GAL4^{αTub84B.Switch.PK}, cnc^UAS.cSa is a suppressor of mitochondrion | adult stage phenotype of Scer\GAL4^Mef2.PR, park^HMS01800

(Gumeni et al., 2021)

ref(2)P^HMS00551, Scer\GAL4^{αTub84B.Switch.PK}, cnc^UAS.cSa is a suppressor of adult somatic muscle cell phenotype of Scer\GAL4^Mef2.PR, park^HMS01800

(Gumeni et al., 2021)

NOT Suppressor of

Statement

Reference

ref(2)P^HMS00551, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

36111

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00551}attP2

NIG-Fly

HMS00551

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00551}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

p62[i2, HMS00551]

(Nagy et al., 2013)

ref(2)P^HMS00551

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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