FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TorsinUAS.cWa
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General Information
Symbol
Dmel\TorsinUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Wakabayashi-Ito
FlyBase ID
FBal0264564
Feature type
allele
Associated gene
Dmel\Torsin
Associated Insertion(s)
Carried in Construct
P{UAS-Torsin.W}
Also Known As
UAS-dtorsin
Key Links
Transgenic product class
cDNA
(Wakabayashi-Ito et al., 2011)
wild_type
(Wakabayashi-Ito et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wakabayashi-Ito et al., 2011)
wild_type
(Wakabayashi-Ito et al., 2011)
Mutagen
in vitro construct
(Wakabayashi-Ito et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Torsin.W}
Cytology
Description

UAS drives expression of a 1.2 kb Torsin cDNA amplified from LD20854.

(Wakabayashi-Ito et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Torsin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TorsinScer\UAS.cWa under the control of Scer\GAL4elav.PU has no significant effect on larval locomotion (peristaltic rate) in third instar larvae.

      (Wakabayashi-Ito et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2015)

      Scer\GAL4elav.PU, TorsinΔD.UAS, TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2015)

      Scer\GAL4Act5C.PU/TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2011)

      Scer\GAL4Tub.PU/TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2011)

      Scer\GAL4elav.PU/TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2011)

      Scer\GAL4ple.PF/TorsinUAS.cWa rescues TorsinKO13

      (Wakabayashi-Ito et al., 2011)

      Scer\GAL4Act5C.PU/TorsinUAS.cWa rescues TorsinKO78

      (Wakabayashi-Ito et al., 2011)

      Scer\GAL4Tub.PU/TorsinUAS.cWa rescues TorsinKO78

      (Wakabayashi-Ito et al., 2011)
      Partially rescues

      TorsinUAS.cWa/Scer\GAL4αTub84B.PL partially rescues TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4da.G32/TorsinUAS.cWa partially rescues TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4arm.PS/TorsinUAS.cWa partially rescues TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4Cg.PA/TorsinUAS.cWa partially rescues TorsinKO78

      (Grillet et al., 2016)

      TorsinUAS.cWa/Scer\GAL4r4 partially rescues TorsinKO78

      (Grillet et al., 2016)
      Fails to rescue

      Scer\GAL4elav-C155/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4btl.PS/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4Mhc.PW/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4fkh.PH/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4Lsp2.PH/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4repo/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4Hml.PG/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4ple.PF/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4nSyb.PS/TorsinUAS.cWa fails to rescue TorsinKO78

      (Grillet et al., 2016)

      Scer\GAL4elav.PU, TorsinUAS.cWa, TorsinΔE.UAS fails to rescue TorsinKO13

      (Wakabayashi-Ito et al., 2015)

      Scer\GAL4Mhc.PW/TorsinUAS.cWa fails to rescue TorsinKO13

      (Wakabayashi-Ito et al., 2011)
      Comments

      Expression of TorsinScer\UAS.cWa under the control of Scer\GAL4αTub84B.PL, Scer\GAL4da.G32, Scer\GAL4arm.PS, Scer\GAL4Cg.PA, or Scer\GAL4r4, but not under the control of Scer\GAL4elav-C155, Scer\GAL4btl.PS, Scer\GAL4Mhc.PW, Scer\GAL4fkh.PH, Scer\GAL4Lsp2.PH, Scer\GAL4repo, Scer\GAL4Hml.PG, Scer\GAL4ple.PF, or Scer\GAL4nSyb.PS, partially rescues the lethality of hemizygous TorsinKO78 flies.

      Expression of TorsinScer\UAS.cWa under the control of Scer\GAL4αTub84B.PL or Scer\GAL4r4, but not Scer\GAL4nSyb.PS, rescues the small fat body size seen in hemizygous TorsinKO78 flies.

      Co-expression of TorsinScer\UAS.cWa and CG14103Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4αTub84B.PL in the third instar fat body results in distended endoplasmic reticulum sheets instead of the small, tubular ER seen in controls, but nuclear morphology appears normal in fat cells.

      (Grillet et al., 2016)

      The deficit in larval locomotion (decreased peristaltic rate) characteristic for TorsinKO13 hemizygous male third instar larvae can be rescued by expression of TorsinScer\UAS.cWa (the rescuing effect is not enhanced further when two copies of the same transgene are used) under the control of Scer\GAL4elav.PU but not by combined expression of TorsinScer\UAS.cWa with TorsinΔE.Scer\UAS. In contrast, combined expression of TorsinScer\UAS.cWa with TorsinΔD.Scer\UAS does rescue the larval locomotion deficit.

      (Wakabayashi-Ito et al., 2015)

      Expression of TorsinScer\UAS.cWa using either Scer\GAL4Act5C.PU or Scer\GAL4tub.PU rescues all the phenotypes shown by TorsinKO13/Y and TorsinKO78/Y hemizygous males.

      Expression of TorsinScer\UAS.cWa using Scer\GAL4elav.PU strongly rescues the TorsinKO13/Y larval mobility defect.

      Expression of TorsinScer\UAS.cWa using Scer\GAL4ple.PF significantly rescues the TorsinKO13/Y larval mobility defect.

      Expression of TorsinScer\UAS.cWa using Scer\GAL4elav.PU does not rescue the TorsinKO13/Y larval mobility defect.

      (Wakabayashi-Ito et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TorsinScer\UAS.cWa
      TorsinUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Wakabayashi-Ito
      Secondary FlyBase IDs
        References (4)