FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\licUAS.ORF
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General Information
Symbol
Dmel\licUAS.ORF
Species
D. melanogaster
Name
FlyBase ID
FBal0287367
Feature type
allele
Associated gene
Dmel\lic
Associated Insertion(s)
Carried in Construct
M{UAS-lic.ORF}
Also Known As
UAS-lic
Key Links
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
in vitro construct
(Schertel et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-lic.ORF}
Cytology
Description

UASt regulatory sequences drive expression of a full-length lic open reading frame with its native stop codon.

(Schertel et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
lic
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing licUAS.ORF under the control of Scer\GAL4ptc.PU induces some cells at the wing disc A/P boundary to delaminate and migrate to the posterior compartment, as well as cell death at the boundary (acridine orange staining). Expression under the control of Scer\GAL4GMR.PU also induces cell death, but not cell invasion, in the eye disc.

      Whole-eye disc clones expressing licUAS.ORF alone under the control of Scer\GAL4Act5C.PP do not form tumors.

      (Sun et al., 2019)

      Flies expressing licScer\UAS.ORF under the control of Scer\GAL4Bx-MS1096 have smaller wings than normal and they show vein-patterning defects (particularly loss of the anterior and posterior crossveins).

      Flies expressing licScer\UAS.ORF under the control of Scer\GAL4hh.PU have smaller wings than normal.

      (Schertel et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Enhancer of
      Other
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Enhancer of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Likewise, whole-eye disc clones co-expressing Ras85DV12.cUa.UAS and licUAS.ORF under the control of Scer\GAL4Act5C.PP form tumors that invade into the VNC.

      (Sun et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      licScer\UAS.ORF
      licUAS.ORF
      Name Synonyms
      Secondary FlyBase IDs
        References (6)