FlyBase Allele Report: Dmel\hep[NIG.4353R]

General Information

Symbol

Dmel\hep^NIG.4353R

Species

D. melanogaster

Name

FlyBase ID

FBal0269068

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

P{NIG.4353R}

Also Known As

UAS-hep-IR

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Sekine et al., 2011, Ishimaru et al., 2004, Ishimaru et al., 2004)

in vitro construct - regulatory fusion

(Sekine et al., 2011, Ishimaru et al., 2004, Ishimaru et al., 2004)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{NIG.4353R}

Cytology

Nature of the lesion

Statement

Reference

UASt drives expression of a hep RNAi construct.

(Sekine et al., 2011)

UASt sequences drive expression of an inverted repeat of hep coding sequences (from GenBank:U05240 nucleotides 646 to 1346).

(Ishimaru et al., 2004)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

hep

Associated Sequence Features

dsRNA-4353R

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hep^NIG.4353R/Scer\GAL4^ptc.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^ptc.PU, fmt^GD6928

(Ma et al., 2017)

hep^NIG.4353R, Scer\GAL4^dpp.blk1 is a suppressor | partially of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

hep^NIG.4353R/Scer\GAL4^ptc.PU is a non-suppressor of cell migration defective | third instar larval stage phenotype of Scer\GAL4^ptc.PU, lic^UAS.ORF

(Sun et al., 2019)

hep^NIG.4353R/Scer\GAL4^GMR.PF is a non-suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, nopo^UAS.cUa

(Ma et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

hep^NIG.4353R/Scer\GAL4^ptc.PU is a suppressor | partially of anterior crossvein phenotype of Scer\GAL4^ptc.PU, fmt^GD6928

(Ma et al., 2017)

hep^NIG.4353R, Scer\GAL4^dpp.blk1 is a suppressor | partially of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

hep^NIG.4353R/Scer\GAL4^ptc.PU is a non-suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, lic^UAS.ORF

(Sun et al., 2019)

hep^NIG.4353R/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, nopo^UAS.cUa

(Ma et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The partial or complete loss of the wing anterior crossvein in flies expressing fmt^GD6928 under the control of Scer\GAL4^ptc.PU is partially suppressed by co-expression of hep^NIG.4353R.

(Ma et al., 2017)

Co-expression of hep^NIG.4353R does not suppress the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

(Ma et al., 2012)

Xenogenetic Interactions

Statement

Reference

Co-expression of hep^NIG.4353R partially suppresses the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

hep^NIG.4153R

hep^NIG.4353R

hep^{dsRNA.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

FBal0175651
FBal0263926

References (17)

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