FlyBase Allele Report: Dmel\nopo[UAS.cUa]

General Information

Symbol

Dmel\nopo^UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0294791

Feature type

allele

Associated gene

Dmel\nopo

Associated Insertion(s)

Carried in Construct

P{UAS-nopo.U}

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-nopo.U}

Cytology

Description

UAS regulatory sequences drive expression of nopo.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

nopo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PF

(Ma et al., 2012)

increased cell death, with Scer\GAL4^sd-SG29.1

(Ma et al., 2012)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Ma et al., 2012)

wing margin, with Scer\GAL4^sd-SG29.1

(Ma et al., 2012)

Detailed Description

Statement

Reference

Expression of nopo^Scer\UAS.cUa in the developing eye, under the control of Scer\GAL4^GMR.PF produces a small and rough eye phenotype, resulting from extensive cell death posterior to the morphogenetic furrow in third instar eye discs.

Expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^sd-SG29.1 triggers strong apoptosis along the dorsal ventral compartment boundary in wing discs, and generated a small wing phenotype missing most of the wing margin tissue.

(Ma et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, enhanceable by ben^UAS.cUa/Uev1A^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, enhanceable by ben^GD1387/Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-enhanceable by ben^GD1387/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-enhanceable by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-enhanceable by Uev1A^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-enhanceable by ben^UAS.cUa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, suppressible by Df(3L)H99

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, suppressible by ben^GD1387/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, suppressible by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-suppressible by Tak1^K46R.UAS/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-suppressible by hep^NIG.4353R/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-suppressible by bsk^DN.UAS/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has increased cell death phenotype, non-suppressible by puc^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, enhanceable by ben^UAS.cUa/Uev1A^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, enhanceable by ben^GD1387/Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-enhanceable by ben^GD1387/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-enhanceable by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-enhanceable by Uev1A^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-enhanceable by ben^UAS.cUa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, suppressible by ben^GD1387/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, suppressible by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, suppressible by Df(3L)H99

(Ma et al., 2012)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-suppressible by Tak1^K46R.UAS/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-suppressible by hep^NIG.4353R/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-suppressible by bsk^DN.UAS/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Scer\GAL4^GMR.PF, nopo^UAS.cUa has eye phenotype, non-suppressible by puc^UAS.cMa/Scer\GAL4^GMR.PF

(Ma et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of dominant-negative Tak1^{K46R.Scer\UAS} does not suppress the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of hep^NIG.4353R does not suppress the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of bsk^DN.Scer\UAS does not suppress the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of puc^Scer\UAS.cMa does not suppress the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of Diap1^Scer\UAS.cHa strongly suppresses the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

A Df(3L)H99 background significantly suppresses the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Loss of ben, through expression of ben^GD1387, significantly suppresses the Scer\GAL4^GMR.PF->nopo^Scer\UAS.cUa small rough eye phenotype.

Loss of Uev1A, through expression of Uev1A^GD6650, significantly suppresses the Scer\GAL4^GMR.PF->nopo^Scer\UAS.cUa small rough eye phenotype.

Co-expression of Uev1A^Scer\UAS.cMa does not enhance the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of ben^Scer\UAS.cUa does not enhance the small, rough eye phenotype found upon expression of nopo^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

Co-expression of Uev1A^Scer\UAS.cMa and ben^Scer\UAS.cUa significantly enhances the Scer\GAL4^GMR.PF->nopo^Scer\UAS.cUa small rough eye phenotype.

(Ma et al., 2012)

Xenogenetic Interactions

Statement

Reference

(Ma et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nopo^Scer\UAS.cUa

nopo^UAS.cUa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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