FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4VT050405
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General Information
Symbol
Scer\GAL4VT050405
Species
S. cerevisiae
Name
FlyBase ID
FBal0308267
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
VT50405-GAL4, SAG-Gal4
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A 2129 base pair fragment from the flanking non-coding or intronic region of CG34347 is fused upstream of a Drosophila synthetic core promoter (DSCP) followed by sequence encoding a GAL4 driver.

Allele components
Component
Use(s)
Regulatory region(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

In the adult female ScerGAL4VT050405 drives expression in a total of 14 cell clusters, eight of these can be found in the adult brain, two in the anterior region of the gnathal ganglion and four clusters in the posterior abdominal ganglion. Two of these neurons in the posterior abdominal ganglion are central targets of SPR expressing sensory neurons in the female reproductive tract. These arborize extensively in the abdominal ganglion and project along the dorsal midline of the gnathal ganglion to the periesophageal region and the posterior superior medial protocerebrum. In adult males labeling is detected in a smaller number of cells in the posterior abdominal ganglion and missing in the posterior superior medial protocerebrum.

 
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Silencing Scer\GAL4VT050405-expressing neurons renders virgin females sexually unreceptive to males. Elevated levels of egg laying are seen. Activating these neurons has no effect effect on virgin receptivity, but drastically increases receptivity after mating compared with controls.

Making Scer\GAL4VT050405-expressing neurons insensitive to sex peptide by expressing SPRGD3236 has no effect on the sexual receptivity of virgin females to males.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Scer\GAL4VT050405
Name Synonyms
Secondary FlyBase IDs
    References (5)