FlyBase Allele Report: Dmel\yki[RNAi.UAS.cUa]

General Information

Symbol

Dmel\yki^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0319327

Feature type

allele

Associated gene

Dmel\yki

Associated Insertion(s)

Carried in Construct

P{UAS-yki.RNAi.U}

Also Known As

UAS-yki^RNAi, Yki RNAi, UAS-yki-RNAi, yki-RNAi, UAS-yki RNAi

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-yki.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of a yki RNA line.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

yki

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by scrib^GD11666

(Ding et al., 2021)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Dubey and Tapadia, 2018)

modeled by Hsap\HTT^Q93.ex1.UAS

(Dubey and Tapadia, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

abnormal size | adult stage, with Scer\GAL4^tj.PU

(Wong et al., 2015)

abnormal size | larval stage, with Scer\GAL4^dpp.PU

(Sansores-Garcia et al., 2011)

abnormal size | larval stage, with Scer\GAL4^hh.PU

(Sansores-Garcia et al., 2011)

increased cell death | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Oh et al., 2014)

visible, with Scer\GAL4^tj.PU

(Wong et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of yki^{dsRNA.UAS.cUa} under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.long, in combination with a Dicer-2 transgene to enhance RNAi efficiency, causes a dramatic increase in the proportion of yellow R8 photoreceptors and a reciprocal decrease in the proportion of pale R8 photoreceptors, compared to controls.

(Jukam et al., 2016)

Adult wings exhibit a decrease in size in flies expressing yki^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^tj.PU (in combination with a Dicer-2 transgene to enhance RNAi efficiency), as compared to controls.

(Wong et al., 2015)

Somatic clones in the third instar larval wing disc expressing yki^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^Act.PU display increased levels of cell death (visualized by an apoptotic marker, cleaved Casp3).

(Oh et al., 2014)

Expression of yki^{dsRNA.UAS.cUa} under the control of Scer\GAL4^hh.PU or Scer\GAL4^dpp.PU results in undergrowth of the expressing region of the wing disc.

(Sansores-Garcia et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh.PU, yki^RNAi.UAS.cUa has abnormal size | larval stage phenotype, non-enhanceable by Scer\GAL4^hh.PU/cpa^KK108554

(Sansores-Garcia et al., 2011)

Scer\GAL4^dpp.PU, yki^RNAi.UAS.cUa has abnormal size | larval stage phenotype, non-enhanceable by Scer\GAL4^dpp.PU/dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa has abnormal neuroanatomy | adult stage phenotype, suppressible by BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

NOT suppressed by

Statement

Reference

Scer\GAL4^hh.PU, yki^RNAi.UAS.cUa has abnormal size | larval stage phenotype, non-suppressible by Scer\GAL4^hh.PU/cpa^KK108554

(Sansores-Garcia et al., 2011)

Scer\GAL4^dpp.PU, yki^RNAi.UAS.cUa has abnormal size | larval stage phenotype, non-suppressible by Scer\GAL4^dpp.PU/dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa, Scer\GAL4^GMR.long is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

yki^RNAi.UAS.cUa/Scer\GAL4^hh.PU is a suppressor of neoplasia | larval stage phenotype of Scer\GAL4^hh.PU, cpa^KK108554

(Sansores-Garcia et al., 2011)

yki^RNAi.UAS.cUa/Scer\GAL4^dpp.PU is a suppressor of neoplasia | larval stage phenotype of Scer\GAL4^dpp.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh.PU, yki^RNAi.UAS.cUa has wing disc phenotype, non-enhanceable by Scer\GAL4^hh.PU/cpa^KK108554

(Sansores-Garcia et al., 2011)

Scer\GAL4^dpp.PU, yki^RNAi.UAS.cUa has wing disc phenotype, non-enhanceable by Scer\GAL4^dpp.PU/dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa has photoreceptor cell R8 of pale ommatidium phenotype, suppressible by BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa has photoreceptor cell R8 of yellow ommatidium phenotype, suppressible by BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

NOT suppressed by

Statement

Reference

Scer\GAL4^hh.PU, yki^RNAi.UAS.cUa has wing disc phenotype, non-suppressible by Scer\GAL4^hh.PU/cpa^KK108554

(Sansores-Garcia et al., 2011)

Scer\GAL4^dpp.PU, yki^RNAi.UAS.cUa has wing disc phenotype, non-suppressible by Scer\GAL4^dpp.PU/dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa, Scer\GAL4^GMR.long is a suppressor | partially of photoreceptor cell R8 of pale ommatidium phenotype of BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

Scer\GAL4^ey.PH, yki^RNAi.UAS.cUa, Scer\GAL4^GMR.long is a suppressor | partially of photoreceptor cell R8 of yellow ommatidium phenotype of BEAF-32^VDRC.cUa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

yki^RNAi.UAS.cUa/Scer\GAL4^hh.PU is a suppressor of wing disc phenotype of Scer\GAL4^hh.PU, cpa^KK108554

(Sansores-Garcia et al., 2011)

yki^RNAi.UAS.cUa/Scer\GAL4^dpp.PU is a suppressor of wing disc phenotype of Scer\GAL4^dpp.PU, dia^{CA.UAS.Tag:HA}

(Sansores-Garcia et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Addition of BEAF-32^VDRC.cUa to flies expressing yki^{dsRNA.UAS.cUa} under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.long reduces the proportion of yellow R8 photoreceptors, to the extent that it is reduced compared to controls.

(Jukam et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

RNAi-yki

(Oh et al., 2014)

yki^RNAi.UAS.cUa

yki^{dsRNA.Scer\UAS.cUa}

yki^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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