Akh^A males exhibit decreased copulation frequency compared to controls; offspring from 1h mating, but not 24h mating, is decreased. Akh^A females produce increased offspring.

Akh^A/Akh^A mutants do not display any gross abnormalities in viability, developmental time, female fecundity, body size (measured as length of thorax), adult spontaneous locomotion, flight performance, corpora cardiaca cell number, carbohydrate and lipid stores between L3 and immature adult stages, or carbohydrate stores in mature adults, as compared with controls.

Akh^A/Akh^A mutants display a significant decrease in hatchability (egg to L1 survival). In the first week of adulthood, Akh^A/Akh^A mutants develop obesity (significantly increased glyceride to protein ratio), along with increased lipid loading and fat body cell hypertrophy, and significantly decreased circulating sugars in the hemolymph. Adult Akh^A/Akh^A mutants show impaired climbing performance, slightly increased wing area, significantly increased starvation resistance, impaired lipid (but not carbohydrate) mobilization during starvation, suppressed starvation-induced hyperactivity, increased survival in response to paraquat feeding, but also increased paraquat-induced food aversion, and decreased oxidative stress resistance when assayed by paraquat application directly to the nerve cord, as compared to controls.