FlyBase Allele Report: Hsap\RELA[AD.R71G01]

General Information

Symbol

Hsap\RELA^AD.R71G01

Species

H. sapiens

Name

FlyBase ID

FBal0329224

Feature type

allele

Associated gene

Hsap\RELA

Associated Insertion(s)

Carried in Construct

P{R71G01-p65.AD}

PBac{R71G01-p65.AD}

Also Known As

R71G01.AD, R71G01-AD

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Rubin Laboratory at Janelia Farm, 2017)

Progenitor genotype

Carried in construct

P{R71G01-p65.AD}

PBac{R71G01-p65.AD}

Cytology

Description

The GMR71G01 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)

Allele components

Component

Use(s)

Regulatory region(s)

GMR71G01

Encoded product / tool

p65(AD)::Zip+

split driver - transcription activation fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult doublesex pC1 (female) neuron

Comment: when combined with P{R15A01-GAL4.DBD}

(Zhou et al., 2015)

adult doublesex pC1 (male) neuron

Comment: when combined with P{R15A01-GAL4.DBD}

(Zhou et al., 2015)

adult bridle subesophageal neuron

Comment: when combined with P{R68B03-GAL4.DBD} (combination referred to as 'SS50098')

when combined with P{VT026953-GAL4.DBD} (combination referred to as 'SS32123')

(Sterne et al., 2021)

adult neuron | subset of superior lateral protocerebrum

Comment: when combined with P{R68B03-GAL4.DBD} (combination referred to as 'SS50098')

(Sterne et al., 2021)

adult neurosecretory neuron | subset of adult metathoracic neuromere

Comment: when combined with P{R68B03-GAL4.DBD} (combination referred to as 'SS50098')

(Sterne et al., 2021)

subesophageal zone neuron | subset

Comment: when combined with P{R68B03-GAL4.DBD} (combination referred to as 'SS50098')

(Sterne et al., 2021)

adult stage | male

adult fruitless P1 (male) neuron | subset

Comment: when combined with P{R22G11-GAL4.DBD}

(Hoopfer et al., 2015)

adult lateral horn | restricted

Comment: when combined with P{R22G11-GAL4.DBD}

(Hoopfer et al., 2015)

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 29[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4^{DBD.R57C10.PU} and Hsap\RELA^AD.R71G01, or Scer\GAL4^DBD.R22G11 and Hsap\RELA^AD.R71G01, in adult males significantly increases aggressive lunging behavior and wing extensions towards other males, compared to controls.

(Hoopfer et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions