The increased number of circulating hemocytes characteristic for OcrlΔ3 mutant third instar larvae is partially suppressed by Scer\GAL4He.PZ-driven expression of either Rab11QL.Scer\UAS or Rab7T22N.Scer\UAS.P\T.T:Avic\GFP-YFP but not Rab5Q88L.Scer\UAS.P\T.T:Avic\GFP-YFP. The expression of Rab11QL.Scer\UAS or Rab7T22N.Scer\UAS.P\T.T:Avic\GFP-YFP also suppresses the increase in F-actin in the mutant hemocytes as well as the expansion of the LysoTracker-positive compartments but it does not rescue the adult lethality of OcrlΔ3 animals. OcrlΔ3 mutants expressing either Rab5S43N.Scer\UAS or Rab11N124I.Scer\UAS (with the Scer\GAL4He.PZ driver) are early larval lethal.
The dramatic increase in the number of circulating hemocytes observed in OcrlΔ3 mutant larvae can be rescued by expression of OcrlScer\UAS.T:Avic\GFP driven by either Scer\GAL4He.PZ or Scer\GAL4Mef2.PU but not by any of the following: Scer\GAL4HHLT, Scer\GAL4dome-PG14, Scer\GAL4Ser.PBS, Scer\GAL4Dot.PK or Scer\GAL4Lsp2.PU.
Scer\GAL4He.PZ-driven expression of neither OcrlH469R.Scer\UAS.T:Avic\GFP nor Ocrlcat.Scer\UAS.P\T.T:Disc\RFP-mCherry.T:Atha\CRY2) can restore the elevated hemocyte numbers but the latter rescues the endocytosis defects in OcrlΔ3 mutant larvae.