FlyBase Allele Report: Dmel\Dbct[Δ]

General Information

Symbol

Dmel\Dbct^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0362463

Feature type

allele

Associated gene

Dmel\Dbct

Associated Insertion(s)

TI{TI}Dbct^Δ

Carried in Construct

Also Known As

dDBT^Δ

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Tsai et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}Dbct^Δ

Cytology

Description

Replacement of the majority of the coding region (beginning near the start codon) of Dbct with a cassette containing attPX, two STOP codons and 3xP3-RFP.

(Tsai et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of maple syrup urine disease

CEA

(Tsai et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal heat stress response | dominant

(Wu et al., 2025)

abnormal locomotor behavior | larval stage

(Tsai et al., 2020)

abnormal neuroanatomy | adult stage

(Tsai et al., 2020)

abnormal neuroanatomy | adult stage | dominant

(Wu et al., 2025)

decreased body size | pupal stage

(Tsai et al., 2020)

decreased rate of adult locomotory behavior | dominant | conditional

(Wu et al., 2025)

decreased rate of larval locomotory behavior

(Wu et al., 2025)

increased cell death | larval stage

(Wu et al., 2025, Tsai et al., 2020)

increased cell death | pupal stage

(Tsai et al., 2020)

lethal

(Tsai et al., 2020)

majority die during P-stage

(Tsai et al., 2020)

partially lethal - majority die

(Wu et al., 2025, Tsai et al., 2020)

short lived

(Tsai et al., 2020)

short lived | dominant

(Wu et al., 2025)

some die during larval stage

(Wu et al., 2025, Tsai et al., 2020)

some die during P-stage

(Wu et al., 2025)

Phenotype Manifest In

adult brain

(Wu et al., 2025, Tsai et al., 2020)

larval brain

(Wu et al., 2025)

larval brain | larval stage

(Tsai et al., 2020)

larval brain | pupal stage

(Tsai et al., 2020)

vacuole | adult stage | increased number

(Wu et al., 2025)

Detailed Description

Statement

Reference

Dbct^Δ heterozygous adults and escaper hemizygous adults are short lived.

Dbct^Δ heterozygous adults show brain vacuoles.

Dbct^Δ hemizygous larvae (Dbct^Δ/Y) show decreased crawling ability; the larval and pupal brains show increased apoptosis.

(Tsai et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dbct^Δ has increased mortality during development phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dbct^Δ has short lived | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dbct^Δ has some die during P-stage phenotype, enhanceable by Scer\GAL4^elav.PLu/mts^{Y307F.Tag:FLAG}

(Wu et al., 2025)

Dbct^Δ has some die during larval stage phenotype, enhanceable by Scer\GAL4^elav.PLu/mts^{Y307F.Tag:FLAG}

(Wu et al., 2025)

Dbct^Δ has increased mortality during development phenotype, enhanceable by Scer\GAL4^elav.PLu/mts^{Y307F.Tag:FLAG}

(Wu et al., 2025)

Dbct^Δ has short lived | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/mts^{Y307F.Tag:FLAG}

(Wu et al., 2025)

Dbct^Δ has increased cell death | larval stage phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dbct^Δ has some die during P-stage phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dbct^Δ has some die during larval stage phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dbct^Δ has decreased rate of larval locomotory behavior phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Suppressed by

Statement

Reference

Dbct^Δ has some die during P-stage phenotype, suppressible | partially by mts^{H118N.Tag:FLAG}/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has some die during larval stage phenotype, suppressible | partially by mts^{H118N.Tag:FLAG}/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has some die during P-stage phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has some die during larval stage phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has short lived | dominant phenotype, suppressible | partially by mts^{H118N.Tag:FLAG}/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has some die during P-stage phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has some die during larval stage phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has decreased rate of larval locomotory behavior phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has short lived | dominant phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has increased cell death | larval stage phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has decreased rate of larval locomotory behavior phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has increased mortality during development phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Dbct^Δ has increased mortality during development phenotype, suppressible | partially by mts^{H118N.Tag:FLAG}/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Other

Statement

Reference

Atg1^GD7149, Dbct^Δ, Scer\GAL4^elav.PLu has partially lethal - majority die phenotype

(Wu et al., 2025)

Atg1^GD7149, Dbct^Δ, Scer\GAL4^elav.PLu has some die during P-stage phenotype

(Wu et al., 2025)

Atg1^GD7149, Dbct^Δ, Scer\GAL4^elav.PLu has some die during larval stage phenotype

(Wu et al., 2025)

Atg1^GD7149, Dbct^Δ, Scer\GAL4^elav.PLu has decreased rate of larval locomotory behavior phenotype

(Wu et al., 2025)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dbct^Δ has larval brain phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Suppressed by

Statement

Reference

Dbct^Δ has larval brain phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dbct^Δ has larval brain phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Wu et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dbct^Δ is rescued by Scer\GAL4^αTub84B.PL/Dbct^UAS.Tag:HA

(Wu et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dbct^Δ

dDBT^Δ

(Wu et al., 2025, Tsai et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

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