FlyBase Allele Report: Dmel\Tnpo[G736D]

General Information

Symbol

Dmel\Tnpo^G736D

Species

D. melanogaster

Name

FlyBase ID

FBal0369502

Feature type

allele

Associated gene

Dmel\Tnpo

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Goodman et al., 2021)

Mutagen

ethyl methanesulfonate

(Goodman et al., 2021)

Progenitor genotype

Cytology

Description

Amino acid replacement: G736D.

(Goodman et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:6,196,534..6,196,534 [+]

Nucleotide change:

G6196534A

Amino acid change:

G736D | Tnpo-PA; G736D | Tnpo-PB; G736D | Tnpo-PC; G736D | Tnpo-PD

Reported amino acid change:

G736D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Goodman et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies

CEC

(Goodman et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage | somatic clone - tissue specific

(Goodman et al., 2021)

lethal - all die before end of larval stage

(Goodman et al., 2021)

lethal - all die before end of larval stage (with Df(3L)Exel8101)

(Goodman et al., 2021)

lethal - all die before end of larval stage (with Tnpo^{CR92235-TG4.2})

(Goodman et al., 2021)

lethal - all die before end of larval stage (with Tnpo^Δ11)

(Goodman et al., 2021)

visible | adult stage | somatic clone - tissue specific

(Goodman et al., 2021)

Phenotype Manifest In

eye | somatic clone - tissue specific

(Goodman et al., 2021)

ommatidium | somatic clone - tissue specific

(Goodman et al., 2021)

wing | somatic clone - tissue specific

(Goodman et al., 2021)

Detailed Description

Statement

Reference

Tnpo^G736D eye clones (ey-FLP-induced) lead to a small, rough eye, with other abnormalities, including disorganized ommatidia.

Tnpo^G736D wing clones (Ubx-FLP-induced) lead to wing notches and large wing blisters.

(Goodman et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, enhanceable by Hsap\TNPO2^UAS.Tag:HA/Scer\GAL4^{Tnpo-CR92235-TG4.2}

(Goodman et al., 2021)

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, enhanceable by Hsap\TNPO2^{Q28R.UAS.Tag:HA}/Scer\GAL4^{Tnpo-CR92235-TG4.2}

(Goodman et al., 2021)

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, enhanceable by Scer\GAL4^{Tnpo-CR92235-TG4.2}/Hsap\TNPO2^{D156N.UAS.Tag:HA}

(Goodman et al., 2021)

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, enhanceable by Scer\GAL4^{Tnpo-CR92235-TG4.2}/Hsap\TNPO2^{W727C.UAS.Tag:HA}

(Goodman et al., 2021)

NOT Enhanced by

Statement

Reference

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, non-enhanceable by Hsap\TNPO2^{W370C.UAS.Tag:HA}/Scer\GAL4^{Tnpo-CR92235-TG4.2}

(Goodman et al., 2021)

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, non-enhanceable by Scer\GAL4^{Tnpo-CR92235-TG4.2}/Hsap\TNPO2^{A546V.UAS.Tag:HA}

(Goodman et al., 2021)

NOT suppressed by

Statement

Reference

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, non-suppressible by Hsap\TNPO2^{W370C.UAS.Tag:HA}/Scer\GAL4^{Tnpo-CR92235-TG4.2}

(Goodman et al., 2021)

Tnpo^{CR92235-TG4.2}/Tnpo^G736D has increased mortality during development phenotype, non-suppressible by Scer\GAL4^{Tnpo-CR92235-TG4.2}/Hsap\TNPO2^{A546V.UAS.Tag:HA}

(Goodman et al., 2021)

Other

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tnpo^G736D

dTnpo^G736D

(Goodman et al., 2021)

dTnpo^Gly736Asp

(Goodman et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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