FlyBase Allele Report: Dmel\Cdkl[CR70087-TG4.2]

General Information

Symbol

Dmel\Cdkl^{CR70087-TG4.2}

Species

D. melanogaster

Name

FlyBase ID

FBal0390525

Feature type

allele

Associated gene

Dmel\Cdkl

Associated Insertion(s)

TI{CRIMIC.TG4.2}Cdkl^{CR70087-TG4.2}

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Gene Disruption Project members, 2018-)

gene targeting by homologous recombination

(Gene Disruption Project members, 2018-)

Progenitor genotype

Associated Insertion(s)

TI{CRIMIC.TG4.2}Cdkl^{CR70087-TG4.2}

Cytology

Description

A TI{CRIMIC.TG4.2} DNA cassette has been inserted into CG7236, in a coding intron, and is predicted to gene trap all annotated transcripts of the gene. The TI{CRIMIC.TG4.2} cassette was inserted via the CRISPR/Cas-9 drop-in technique, using a dsDNA donor vector with homology arms of length 200bp. The sgRNA sequence used to target the gene was: CGGAATTCCCACCCCGATTGCGG.

(Gene Disruption Project members, 2018-)

Allele components

Component

Use(s)

Inserted element

TI{CRIMIC.TG4.2}

gene trap

RMCE target element

Encoded product / tool

GAL4

binary expression system - driver

Also carries

attP

integrase target site

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion_site

2L:5,712,189..5,712,190 [+]

(Bereshneh et al., 2025, Gene Disruption Project members, 2018-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antenna (with Cdkl^SK8)

(Bereshneh et al., 2025)

antenna (with Df(2L)ED270)

(Bereshneh et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has increased mortality during development phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has increased mortality during development phenotype, suppressible by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has increased mortality during development phenotype, suppressible by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has increased mortality during development phenotype, suppressible by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has increased mortality during development phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible | partially by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, suppressible | partially by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, suppressible | partially by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, suppressible by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL5^UAS.cBa

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal heat stress response | adult stage phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL5^UAS.cBa

(Bereshneh et al., 2025)

NOT suppressed by

Statement

Reference

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has partially lethal - majority die phenotype, non-suppressible by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has partially lethal - majority die phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has partially lethal - majority die phenotype, non-suppressible by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has short lived phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has abnormal neurophysiology | adult stage phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Other

Statement

Reference

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{R169C.UAS.Tag:HA}, Hsap\CDKL1^UAS.Tag:HA has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{R169C.UAS.Tag:HA}, Hsap\CDKL1^UAS.Tag:HA has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^E333VE.UAS, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^E333VE.UAS, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^M215L.UAS, Hsap\CDKL2^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^M215L.UAS, Hsap\CDKL2^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^M215L.UAS, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^M215L.UAS, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^N468S.UAS, Hsap\CDKL2^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^N468S.UAS, Hsap\CDKL2^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^N468S.UAS, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^N468S.UAS, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{R169C.UAS.Tag:HA}, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^S119G.UAS, Hsap\CDKL2^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^S119G.UAS, Hsap\CDKL2^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^S119G.UAS, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^S119G.UAS, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{R169C.UAS.Tag:HA}, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^UAS.Tag:HA, Hsap\CDKL1^{V115A.UAS.Tag:HA} has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^UAS.Tag:HA, Hsap\CDKL1^{V115A.UAS.Tag:HA} has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{V115A.UAS.Tag:HA}, Hsap\CDKL5^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL1^{V115A.UAS.Tag:HA}, Hsap\CDKL5^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^E333VE.UAS, Hsap\CDKL2^UAS.cBa has abnormal heat stress response | adult stage phenotype

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2}, Hsap\CDKL2^E333VE.UAS, Hsap\CDKL2^UAS.cBa has decreased rate of adult locomotory behavior phenotype

(Bereshneh et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL1^UAS.Tag:HA

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, suppressible by Hsap\CDKL2^UAS.cBa/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, suppressible | partially by Hsap\CDKL1^{V115A.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, suppressible | partially by Hsap\CDKL1^{R169C.UAS.Tag:HA}/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

NOT suppressed by

Statement

Reference

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, non-suppressible by Hsap\CDKL2^M215L.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^N468S.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, non-suppressible by Scer\GAL4^{Cdkl-CR70087-TG4.2}/Hsap\CDKL2^S119G.UAS

(Bereshneh et al., 2025)

Df(2L)ED270/Cdkl^{CR70087-TG4.2} has antenna phenotype, non-suppressible by Hsap\CDKL2^E333VE.UAS/Scer\GAL4^{Cdkl-CR70087-TG4.2}

(Bereshneh et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98479

y¹ w^*; TI{CRIMIC.TG4.2}Cdkl^{CR70087-TG4.2}/SM6a

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG7236^{CR70087-TG4.2}

Cdkl^{CR70087-TG4.2}

Cdkl^T2A-GAL4

(Bereshneh et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (2)

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