FlyBase Allele Report: Dmel\Mtx2[ΔDsRed]

General Information

Symbol

Dmel\Mtx2^ΔDsRed

Species

D. melanogaster

Name

FlyBase ID

FBal0407314

Feature type

allele

Associated gene

Dmel\Mtx2

Associated Insertion(s)

TI{TI}Mtx2^ΔDsRed

Carried in Construct

Also Known As

dMtx2^ΔDsRed

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhang et al., 2025)

Mutagen

CRISPR/Cas9

(Zhang et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}Mtx2^ΔDsRed

Cytology

Description

A full deletion allele of Mtx2, in which the the coding sequence is replaced with a dsRed marker.

(Zhang et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:19,927,555..19,928,437 [-]

Comment:

Inferred coordinates of Mtx2^DeltaDsRed, in which the Mtx2 CDS is replaced with a dsRed marker.

(Zhang et al., 2025)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior | progressive (with Mtx2^EGFP-)

(Zhang et al., 2025)

fertile | dominant

(Zhang et al., 2025)

lethal (with Mtx2¹)

(Shou et al., 2026)

lethal - all die during pharate adult stage (with Mtx2¹)

(Zhang et al., 2025)

lethal - all die during pharate adult stage | recessive

(Zhang et al., 2025)

short lived (with Mtx2¹), with Mtx2^UAS.EGFP, Scer\GAL4^Mef2.PR

(Shou et al., 2026)

short lived (with Mtx2^EGFP-)

(Zhang et al., 2025)

short lived | female (with Mtx2¹), with Mtx2^UAS.EGFP, Scer\GAL4^Act5C.PU

(Shou et al., 2026)

some die during P-stage (with Mtx2¹)

(Shou et al., 2026)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, suppressible by Myc^UAS.cZa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, suppressible by Scer\GAL4^Act5C.PU/Hsap\MTX2^UAS.EGFP

(Shou et al., 2026)

NOT suppressed by

Statement

Reference

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Scer\GAL4^Mef2.PR/Diap1^UASp.cPa

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Pi3K92E^UAS.cUa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Akt^UAS.cUa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Scer\GAL4^Mef2.PR/BacA\p35^UAS.cHa

(Shou et al., 2026)

Other

Statement

Reference

Mtx2¹/Mtx2^ΔDsRed, Myc^UAS.cZa, Scer\GAL4^Mef2.PR has short lived phenotype

(Shou et al., 2026)

Hsap\MTX2^UAS.EGFP, Mtx2¹/Mtx2^ΔDsRed, Scer\GAL4^Act5C.PU has short lived phenotype

(Shou et al., 2026)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Act5C.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Mef2.PR/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2^ΔDsRed is rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Partially rescued by

Mtx2¹/Mtx2^ΔDsRed is partially rescued by Scer\GAL4^Mhc.PK/Mtx2^UAS.EGFP

(Shou et al., 2026)

Not rescued by

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^Cg.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^repo/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^Hand.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^nSyb.PS/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mtx2^ΔDsRed

dMtx2^ΔDsRed

(Shou et al., 2026, Zhang et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (2)

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