Gene Group: TRANSMEMBRANE CARRIER PROTEINS

General Information

Name

TRANSMEMBRANE CARRIER PROTEINS

Species

D. melanogaster

Symbol

SLC

FlyBase ID

FBgg0000686

Date last reviewed

2024-09-20

Number of members

405

Description

Transmembrane carrier proteins transport a wide array of ions and molecules by a process that involves conformational changes to mediate movement of the substrate in an energy-independent fashion. Carriers may be classed as passive (facilitated diffusion) transporters (uniporters), transporting a substrate down its electrochemical gradient, or secondary active transporters, coupling the transport of substrates against their electrochemical gradients with the transport of other substrates down their electrochemical gradients. Secondary active transporters may act as symporters, transporting substrates in the same direction, or antiporters, transporting substrates in opposite directions. The majority of transmembrane carrier proteins are classified as members of the Solute carrier (SLC) family. (Adapted from PMID:31214990, PMID:32810346, FBrf0234984 and FBrf0226917.)

Notes on Group

Source Material

The TRANSMEMBRANE CARRIER PROTEINS Gene Group has been compiled using the following publication(s): Attrill, 2024.3.4, Byrne et al., 2023, François et al., 2023, Ceder and Fredriksson, 2022, Ceder et al., 2021, Vulpe et al., 2021, Ceder et al., 2020, Ceder et al., 2020, Chang et al., 2020, Curcio et al., 2020, Denecke et al., 2020, Deshpande et al., 2020, Engelhart et al., 2020, Lecompte et al., 2020, Connolly et al., 2019, Valoskova et al., 2019, Kory et al., 2018, Suda et al., 2018, Zheng et al., 2018, Chiang et al., 2017, Graham et al., 2017.2.7, Han et al., 2017, Hebbar et al., 2017, Manole et al., 2017, Paik et al., 2017, Perland et al., 2017, Vozza et al., 2017, Yin et al., 2017, Cui et al., 2016, Gai et al., 2016, Richards and Burke, 2016, Slabbaert et al., 2016, Xiao and Zhou, 2016, Chintapalli et al., 2015, Dechen et al., 2015, Dourlen et al., 2015, Saha et al., 2015, Volkenhoff et al., 2015, Cabrero et al., 2014, Da-Rè et al., 2014, Limmer et al., 2014, Martin and Krantz, 2014, Chintapalli et al., 2013, Dus et al., 2013, Hu et al., 2013, Lunetti et al., 2013, Lye et al., 2013, Mandilaras et al., 2013, Melom and Littleton, 2013, Qin et al., 2013, Sekine et al., 2013, Bergwitz et al., 2012, Hirata et al., 2012, Lye et al., 2012, Mandilaras and Missirlis, 2012, Ogmundsdóttir et al., 2012, Yamamoto-Hino et al., 2012, Featherstone, 2011, Iacopetta et al., 2011, Meyer et al., 2011, Wieczorek, 2011.7.27, Wu et al., 2011, Charrière et al., 2010, Fei et al., 2010, Hua et al., 2010, Knight et al., 2010, Norgate et al., 2010, Steiger et al., 2010, Sun et al., 2010, Jiang et al., 2009, Reynolds et al., 2009, Wang et al., 2009, Day et al., 2008, Jang et al., 2008, Kolodziejczyk et al., 2008, Laridon et al., 2008, Lindsay et al., 2008, Southon et al., 2008, Enell et al., 2007, Machado et al., 2007, Norgate et al., 2007, Romero-Calderon et al., 2007, Rose et al., 2007, Turski and Thiele, 2007, Wang et al., 2007, Goda et al., 2006, Thimgan et al., 2006, Besson et al., 2005, Goberdhan et al., 2005, Traiffort et al., 2005, Eraly et al., 2004, Hirabayashi et al., 2004, Torrie et al., 2004, Winkfein et al., 2004, Dow and Davies, 2003, Freeman et al., 2003, Zhou et al., 2003, Knauf et al., 2002, Sankar et al., 2002, Giannakou and Dow, 2001, Besson et al., 2000, Nelson, 2000.4.10, Rogina et al., 2000, Romero et al., 2000, Besson et al., 1999, Haug-Collet et al., 1999, Artero et al., 1998, Orgad et al., 1998, Schwarz and Benzer, 1997, and Rodrigues et al., 1995 .

Key Gene Ontology (GO) terms

Molecular Function

transmembrane transporter activity

Biological Process

transmembrane transport

Cellular Component

membrane

Related Gene Groups

Parent group(s)

TRANSMEMBRANE TRANSPORTERS

Component group(s)

ATYPICAL SOLUTE CARRIERS