FlyBase Gene Report: Dmel\AnxB10

General Information

Symbol

Dmel\AnxB10

Species

D. melanogaster

Name

Annexin B10

Annotation Symbol

CG9579

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000084

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Annexin B10 (AnxB10) encodes a calcium-dependent phospholipid binding protein. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

AnnX, Annexin X, anxX

Key Links

Genomic Location

Cytogenetic map

19C1-19C1

Sequence location

X:20,171,445..20,173,514 [-]

Recombination map

1-64

RefSeq locus

NC_004354 REGION:20171445..20173514

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables calcium-dependent phospholipid binding

inferred from direct assay

(Johnston et al., 1990)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502, InterPro:IPR037104

(InterPro Project Members, 2004-)

enables calcium-dependent phospholipid binding

inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502, InterPro:IPR037104

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000052507

(GO Reference Genome Project, 2011-)

enables phosphatidylserine binding

inferred from biological aspect of ancestor with PANTHER:PTN000052507

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000052507

(GO Reference Genome Project, 2011-)

located_in membrane

inferred by curator from GO:0005544

(Johnston et al., 1990)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000052508

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000052507

(GO Reference Genome Project, 2011-)

is_active_in vesicle membrane

inferred from biological aspect of ancestor with PANTHER:PTN000052508

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ANNEXINS

Protein Family (UniProt)

Belongs to the annexin family. (P22465)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Annexin B10 (AnxB10) encodes a calcium-dependent phospholipid binding protein. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

ANNEXINS -: Annexins are Ca²⁺-dependent, phospholipid-binding proteins that are proposed to have multiple roles in membrane traffic. They contain a seventy amino acid sequence repeated four to eight times that mediates their Ca²⁺- and phospholipid-binding properties. (Adapted from PMID:11917092).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\AnxB10 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P22465)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

AnxB10-RA

FBtr0070025

NM_057267

1244

320

AnxB10-RB

FBtr0301931

NM_001169333

1247

321

Additional Transcript Data and Comments

Reported size (kB)

1.4 (northern blot)

(Johnston et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

AnxB10-PA

FBpp0070024

35.6

320

4.40

NP_476615

AAF45380

AnxB10-PB

FBpp0291143

35.7

321

4.37

P22465

NP_001162804

ACZ95337

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

321 (aa)

(Johnston et al., 1990)

Comments

External Data

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

(UniProt, P22465)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P22465

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AnxB10 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.75

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

(Johnston et al., 1990)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

larval circulatory system

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Johnston et al., 1990)

Additional Descriptive Data

AnxB10 transcripts are very abundant in adults and weakly expressed in embryos.

(Johnston et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AnxB10 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\AnxB10

View exonic expression by tissue for Dmel\AnxB10

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000084

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33019/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000084

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000084

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000084

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9579

Flygut - An atlas of the Drosophila adult midgut

FBgn0000084

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\AnxB10

Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of AnxB10

Transgenic constructs containing regulatory region of AnxB10

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

AnxB10^d03410

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AnxB10^GD14255

viable, with Scer\GAL4^Mef2.PR

AnxB10^GD14255

viable, with Scer\GAL4^pnr-MD237

AnxB10^GD14255

viable, with Scer\GAL4^tin.CΔ4

AnxB10^GD14255

Sterility

Allele

fertile

AnxB10^d03410

Other Phenotypes

Allele

abnormal wound healing | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

Phenotype manifest in

Allele

actomyosin contractile ring actin filament | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\ANXA8

9 of 14

Yes

Hsap\ANXA8L1

9 of 14

Yes

8 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

6 of 14

Yes

Hsap\ANXA3

6 of 14

Hsap\ANXA6

6 of 14

Yes

Hsap\ANXA10

6 of 14

Yes

Hsap\ANXA2P2

5 of 14

Yes

Hsap\ANXA9

5 of 14

Yes

Hsap\GRINA

1 of 14

Hsap\PRNP

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Anxa7

8 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

Yes

7 of 14

7 of 14

6 of 14

6 of 14

Yes

Rnor\Anxa10

6 of 14

Yes

Rnor\Anxa9

5 of 14

Yes

Rnor\Prnp

1 of 14

Yes

Mus musculus (laboratory mouse) (13)

Mmus\Anxa7

8 of 14

Yes

Mmus\Anxa8

8 of 14

Yes

Mmus\Anxa1

7 of 14

Yes

7 of 14

7 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

Yes

Mmus\Anxa13

6 of 14

Mmus\Anxa9

5 of 14

Yes

Mmus\Prnp

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (16)

Xtro\anxa7

7 of 13

Yes

Xtro\anxa6

6 of 13

Yes

Xtro\anxa11

6 of 13

Xtro\anxa13

6 of 13

Yes

Xtro\anxa1.1

4 of 13

Yes

Xtro\anxa3

4 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

Yes

Xtro\anxa9

2 of 13

Yes

Xtro\anxa10

2 of 13

Yes

Xtro\sec24d

2 of 13

Xtro\anxa1.2

1 of 13

Yes

Xtro\fhl1

1 of 13

Danio rerio (Zebrafish) (18)

Drer\anxa1a

8 of 14

Yes

Drer\anxa5a

8 of 14

Yes

Drer\anxa1b

7 of 14

Yes

Drer\anxa1c

7 of 14

Yes

Drer\anxa1d

7 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

6 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

Yes

Drer\anxa14

3 of 14

Drer\LOC100006250

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\nex-1

6 of 14

Yes

Cele\nex-2

6 of 14

Yes

Cele\nex-3

6 of 14

Yes

Cele\nex-4

5 of 14

Yes

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP003720

12 of 12

Yes

Agam\ANXB10B

12 of 12

Yes

Agam\ANXB10C

12 of 12

Yes

Agam\AgaP_AGAP012784

11 of 12

Yes

Agam\AgaP_AGAP012624

5 of 12

Yes

Agam\AgaP_AGAP012625

5 of 12

Yes

Agam\ANXB9

5 of 12

Agam\AgaP_AGAP012930

3 of 12

Yes

Agam\AgaP_AGAP003719

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\ANN5

11 of 13

Yes

Atha\ANN6

10 of 13

Yes

Atha\ANNAT1

10 of 13

Yes

Atha\ANNAT2

10 of 13

Yes

Atha\ANNAT7

10 of 13

Yes

Atha\ANNAT8

9 of 13

Atha\ANNAT3

7 of 13

Atha\ANNAT4

3 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:AnxB10. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

AnxB9

10 of 13

AnxB11

10 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

AnxB10^d03410

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANXA8; annexin A8

9 of 14

602396

ANXA8L1; annexin A8 like 1

9 of 14

8 of 14

7 of 14

7 of 14

7 of 14

PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 3; RPRGL3

7 of 14

7 of 14

6 of 14

6 of 14

6 of 14

6 of 14

ANXA2P2; annexin A2 pseudogene 2

5 of 14

ANXA9; annexin A9

5 of 14

603319

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

AnxB10 - 14-3-3ε

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - 14-3-3ζ

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - ATPsynCF6

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - ATPsynβ

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Acaa

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Akap200

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Aldo

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - AnxB9

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Aos1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Ar1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Ar2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Bacc

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG11267

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG11842

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG13887

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG14715

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG15084

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG15717

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG1910

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG2004

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG2852

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG4598

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG5174

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG5355

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG7054

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG7675

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG8993

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - CG9672

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Calr

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Clic

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Corp

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Cyp1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Dera

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Df31

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - ERp60

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Eb1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - EndoGI

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Eno

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Fim

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Fkbp12

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Fkbp14

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Gapdh1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Gdi

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Glo1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - GstE6

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - GstO3

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Gtpx

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - HINT1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - HmgD

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Hsp110

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Hsp83

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Inos

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Jupiter

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Mdh2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Moe

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - ND-20

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Naa20A

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Nlp

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Nph

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Ntf-2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - PCNA

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - PHDP

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

AnxB10 - Pdi

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Pgam1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Pgd

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Pgk

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Phb1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosα1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosα2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosα4

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosα6

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosα7

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosβ3

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosβ5

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosβ6

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prosβ7

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Prx6c

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - RhoGDI

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - SelT

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Sod1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Srlp

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Stip1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Sumo

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - TER94

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Tctp

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Tkt

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Trx2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Trxr1

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - UbcE2M

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Uch

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - Usp39

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - awd

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - cPges

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - capt

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - chic

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - cib

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - dUTPase

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - dod

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - eEF1δ

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - eEF2

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - eEF5

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - fabp

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - porin

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - scf

experimental knowledge based

(Guruharsha et al., 2011)

AnxB10 - scu

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0000084

MIST (protein-protein) - An integrated Molecular Interaction Database

33019

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

19C1-19C1

Sequence location

X:20,171,445..20,173,514 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19C1-19C1

Limits computationally determined from genome sequence between P{EP}amn^EP1639&P{EP}amn^EP367 and P{EP}CG1702^EP1525

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

19A4-19A7

(Benevolenskaya, 1995)

19A4-19A7

(determined by in situ hybridisation)

(Johnston et al., 1990)

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-63.8

(Comeron et al., 2012)

(Benevolenskaya, 1995)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

605571

P{sqh-sfGFP-AnxB10}10, w^*

605573

w^*; P{sqh-sfGFP-AnxB10}30

19193

w¹¹¹⁸ P{XP}AnxB10^d03410

62443

y¹ v¹; P{TRiP.HMJ23898}attP40/CyO

92520

y¹ v¹; P{U6.2-AnxB10.dgRNA}attP40

605572

w^*; P{sqh-sfGFP-AnxB10}20; MKRS/TM6B, Tb¹

78958

y¹ w^* TI{CRIMIC.TG4.0}AnxB10^{CR00582-TG4.0}

41880

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02294}attP2

9579R-2

v109568

v36107

w¹¹¹⁸; P{GD14255}v36107

v341827

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00978}attP40/CyO-GFP

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (131)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD25605

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000084

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000084

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The annexins are a family of homologous calcium and phospholipid binding proteins that are also found in vertebrates.

(Johnston et al., 1990)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: AnxB10 AnnX

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'AnnX' to 'AnxB10' in order to make the nomenclature of D. melanogaster Annexins consistent with each other and with the standard Annexin nomenclature.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

ANXB10

(Iglesias et al., 2002)

Ann

(Robinson and Cooley, 1996)

AnnB10

(Scholz et al., 2019)

AnnX

(Long et al., 2013, Butchar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rettie and Dorus, 2012, Yeh et al., 2012, Michaut et al., 2011, Vidal et al., 2010, Ponce, 2009, Ponce, 2007, Ponce and Hartl, 2006)

Annx

(Bartolome and Charlesworth, 2006, Benevolenskaya, 1995)

AnxB10

(Nakamura and Parkhurst, 2024, Onur et al., 2021, Pang et al., 2021, Clifton et al., 2020, Boucher et al., 2019, Gene Disruption Project members, 2018-, Walls et al., 2018, Clifton et al., 2017, Kline et al., 2017, Schwartz et al., 2016, Aradska et al., 2015, Thomae et al., 2013, Tjota et al., 2011)

CG9579

(Trivedi et al., 2020, Meadows, 2014.12.12, Chen et al., 2012, Cammarato et al., 2011, Zhan et al., 2011, Ni et al., 2010.12.1, Vidal et al., 2010, Zhang et al., 2010, Goldstein and Gunawardena, 2000)

annexin

(Löw et al., 2007)

anxX

(Benevolenskaya et al., 1995, Benevolenskaya, 1994.3.21)

Name Synonyms

Annexin B10

Annexin X

(Rettie and Dorus, 2012, Yeh et al., 2012, Cammarato et al., 2011, Wang et al., 2006)

annexin X

(Ponce, 2007)

dAnnexin X

(Walls et al., 2018)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33019

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P22465

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P22465

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P22465

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000084

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33019/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000084

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000084

FlyMine - An integrated database for Drosophila genomics

FBgn0000084

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9579

MARRVEL_MODEL - MARRVEL (model organism gene)

33019

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000084

DroID - A comprehensive database of gene and protein interactions.

FBgn0000084

DRSC - Results frm RNAi screens

FBgn0000084

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000084

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000084

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9579

Flygut - An atlas of the Drosophila adult midgut

FBgn0000084

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000084

MIST (protein-protein) - An integrated Molecular Interaction Database

33019

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (96)

The following external sites may use different assemblies or annotations than FlyBase.

0.75

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