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FB2026_01
,
released March 12, 2026
DHODH, l(3)s3512
Please see the JBrowse view of Dmel\Dhod for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.47
1.3 (northern blot, longest cDNA)
1.6, 1.5 (northern blot)
405 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dhod using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The 1.5 kb Dhod transcript is most abundant in early embryos, and least abundant in mid-larval stages. It is present in intermediate amounts in mid-embryonic and mid-pupal stages, and in adult flies of both sexes.
Using an enzyme assay, Dhod protein activity is demonstrated in elongated spermatid bundles, but is absent from earlier and later stages.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dhod in JBrowseNo recombinants with pp among 11,618 offspring of heterozygous mothers.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
A novel class of Dhod RNA of approximately 1.6kb is relatively abundant in adult males. Expression of a male specific promoter is limited to spermatogenic cells. This RNA is subject to a translational delay system operative during spermatogenesis.
Structural organisation, embryonic transcript and protein product of Dhod are characterised.
Dhod was involved in a complementation analysis of the 85A region.
Likely to be the structural gene for dehydroorotate dehydrogenase, which catalyzes the fourth enzymatic step of de novo pyrimidine biosynthesis (DHOdehase). Homozygotes for null alleles display less than 3% normal levels of enzyme activity; heterozygotes have half-normal levels; flies with three normal alleles show increased levels. Enzyme appears to be monomeric; no interallelic complementation among null alleles. Enzyme activity located in outer surface of inner mitochondrial membrane in other species; also mitochondrial in Drosophila. Homozygotes for null alleles exhibit wing truncation, irregular lengths and distribution of hairs on wing margin, deformed posterior legs and female sterility, as seen in r and r-l. Viability normal. Phenotype suppressed, but enzyme level not restored, by su(r). Null mutants suppress eye mottling characteristic of r-l in doubly mutant genotypes.
Source for merge of: Dhod l(3)s3512
Source for identity of: Dhod CG9741
