FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Mvl
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General Information
Symbol
Dmel\Mvl
Species
D. melanogaster
Name
Malvolio
Annotation Symbol
CG3671
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011672
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn2+ and Fe2+. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dNRAMP, DMT1

Key Links
Genomic Location
Cytogenetic map
93B7-93B8
Sequence location
Recombination map
3-70
RefSeq locus
NT_033777 REGION:21051383..21060800
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables copper ion transmembrane transporter activity
inferred from mutant phenotype
(Southon et al., 2008)
enables iron ion transmembrane transporter activity
inferred from mutant phenotype
(Orgad et al., 1998)
enables manganese ion transmembrane transporter activity
inferred from mutant phenotype
(Orgad et al., 1998)
enables symporter activity
inferred from genetic interaction with SGD:S000001092,SGD:S000004024,SGD:S000005482
(Techau et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables iron ion transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000194435
(GO Reference Genome Project, 2011-)
enables manganese ion transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
enables metal ion transmembrane transporter activity
inferred from electronic annotation with InterPro:IPR001046
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in copper ion homeostasis
inferred from mutant phenotype
(Southon et al., 2008)
involved_in copper ion import
inferred from mutant phenotype
(Southon et al., 2008)
involved_in iron ion transmembrane transport
inferred from mutant phenotype
(Bettedi et al., 2011)
involved_in metal ion transport
inferred from genetic interaction with SGD:S000001092,SGD:S000004024,SGD:S000005482
(Techau et al., 2007)
involved_in positive regulation of iron ion transmembrane transport
inferred from mutant phenotype
(Panda et al., 2013)
involved_in sensory perception of sweet taste
inferred from mutant phenotype
(Orgad et al., 1998, Rodrigues et al., 1995)
involved_in symbiont entry into host cell
inferred from mutant phenotype
(Rose et al., 2011)
involved_in transition metal ion transport
inferred from mutant phenotype
(Orgad et al., 1998)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in intracellular iron ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
involved_in intracellular manganese ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
involved_in iron ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
involved_in manganese ion transport
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
involved_in metal ion transport
inferred from electronic annotation with InterPro:IPR001046
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Southon et al., 2008)
located_in membrane
inferred from direct assay
(Techau et al., 2007)
located_in plasma membrane
inferred from direct assay
(Southon et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in endosome membrane
inferred from biological aspect of ancestor with PANTHER:PTN000194435
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR001046
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000194431
(GO Reference Genome Project, 2011-)
located_in plasma membrane
inferred from sequence model
(Rodrigues et al., 1995)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the NRAMP family. (P49283)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn2+ and Fe2+. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
SLC11 FAMILY OF PROTON-COUPLED METAL ION TRANSPORTERS -
Solute carrier family 11 (SLC11) are proton coupled transporter of several divalent metal ions including Fe+2, Cu+2 and Mn+2. (Adapted from FBrf0100379 and FBrf0203166).
Protein Function (UniProtKB)
Putative transporter required for normal taste behavior. May be a nitrite/nitrate transporter.
(UniProt, P49283)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Mvl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P49283)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.39

Gene model reviewed during 5.44

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mvl-RB
FBtr0089521
NM_169944
2653
596
Mvl-RD
FBtr0301477
NM_001170197
4782
596
Mvl-RE
FBtr0301478
NM_079701
2790
596
Mvl-RF
FBtr0306350
NM_206529
2503
605
Mvl-RG
FBtr0306351
NM_001260292
2221
607
Mvl-RH
FBtr0330046
NM_001275866
2653
639
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Rodrigues et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mvl-PB
FBpp0088507
65.5
596
6.11
P49283
NP_732584
AAN13847
Mvl-PD
FBpp0290692
65.5
596
6.11
P49283
NP_001163668
ACZ94964
Mvl-PE
FBpp0290693
65.5
596
6.11
P49283
NP_524425
AAF55839
Mvl-PF
FBpp0297443
66.4
605
6.50
NP_996251
AAS65187
Mvl-PG
FBpp0297444
66.9
607
7.14
A0A0B4K7L4
NP_001247221
AFH06539
Mvl-PH
FBpp0303079
69.8
639
5.30
A0A0B4KGL5
NP_001262795
AGB96175
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

596 aa isoforms: Mvl-PB, Mvl-PD, Mvl-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

486 (aa); 53 (kD predicted)

(Rodrigues et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mvl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.97

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
embryonic stage 10
tracheal pit | vicinity of
(Rodrigues et al., 1995)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
embryonic/larval salivary gland body
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 17
embryonic/larval salivary gland
(Maruyama et al., 2011)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Rodrigues et al., 1995)
embryonic stage 10
procephalic segment
(Rodrigues et al., 1995)
embryonic stage 16
amnioserosa
(Rodrigues et al., 1995)
larval antenno-maxillary sensory complex
(Rodrigues et al., 1995)
Additional Descriptive Data

Mvl is expressed at later stages embryonic salivary glands and expression is decreased in fkh mutants.

(Maruyama et al., 2011)

Mvl transcripts are expressed in embryos, downregulated in first and second instar larvae, increase again in third instars and maintained in pupae and adults. Transcripts are first detected by in situ hybridization in germband extended embryos in cells surrounding the tracheal pits and in the procephalic lobe. Staining is observed along the posterior border of segment boundaries during germband retraction. Expression occurs in the amnioserosa and is observed as two rows of cells during dorsal closure. The most prominent neuronal expression is in the cells of the antenno-maxillary complex.

(Rodrigues et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mvl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mvl
Transgenic constructs containing regulatory region of Mvl
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\SLC11A1
13 of 14
Yes
Yes
 
1  
Hsap\SLC11A2
13 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Slc11a2
13 of 14
Yes
Yes
Rnor\Slc11a1
11 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Slc11a2
13 of 14
Yes
Yes
Mmus\Slc11a1
12 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\slc11a2
8 of 13
Yes
Yes
Xtro\slc11a1
6 of 13
No
Yes
Xtro\syf2
5 of 13
No
No
Xtro\cep104
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\slc11a2
8 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\smf-1
12 of 14
Yes
Yes
Cele\smf-2
12 of 14
Yes
Yes
Cele\smf-3
12 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP012464
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (7)
Atha\NRAMP5
13 of 13
Yes
Yes
Atha\NRAMP2
12 of 13
No
Yes
Atha\NRAMP3
12 of 13
No
Yes
Atha\NRAMP4
12 of 13
No
Yes
Atha\NRAMP1
8 of 13
No
Yes
Atha\NRAMP6
8 of 13
No
Yes
Atha\EIN2
4 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\SMF2
11 of 13
Yes
Yes
Scer\SMF1
10 of 13
No
Yes
Scer\SMF3
10 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\pdt1
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (1)
Ecol\mntH
10 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mvl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SLC11A2; solute carrier family 11 member 2
    model of  hypochromic microcytic anemia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Interaction
    References
    MvlGD3095
    ameliorates  Parkinson's disease 6
    modeled by Pink1B9
    (Xia et al., 2024)
    MvlKK108406
    ameliorates  Friedreich ataxia 1
    modeled by fhRNAi.UAS.cAa
    (Soriano et al., 2016)
    MvlUAS.cXa
    ameliorates  Parkinson's disease 6
    modeled by Pink1B9
    (Xia et al., 2024)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC11A1; solute carrier family 11 member 1
    13 of 14
    600266
       
      SLC11A2; solute carrier family 11 member 2
      13 of 14
      600523
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Mvl
      Hsap\SLC11A1
      (D'Souza et al., 1999)
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ATP7
      enhanceable
      Mvl
      (Southon et al., 2008)
      Pink1
      suppressible
      Mvl
      (Xia et al., 2024)
      Pink1
      enhanceable
      Mvl
      (Xia et al., 2024)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-70
      Cytogenetic map
      93B7-93B8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      93B7-93B8
      Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      93B6-93B6
      (Cheah, 1995.4.3)
      93B6-93B6
      (determined by in situ hybridisation)
      (Rodrigues et al., 1995)
      Experimentally Determined Recombination Data
      Location

      3-70

      (FlyBase, 2016)

      3-73.4

      (Comeron et al., 2012)

      3-

      (Cheah, 1995.4.3, Rodrigues et al., 1995)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (12)
      Genomic Clones (18)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (74)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Folwell et al., 2006)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
        Other Comments

        Isolated by homology to mammalian Nramp, Natural resistance-associated macrophage protein. Mutants exhibit altered gustatory behaviour and are defective in the neural pathway processing or discriminating gustatory information.

        (Cellier et al., 1995)

        The Mvl gene was identified in a screen for mutants that affect taste behaviour. Based on its mutant phenotype, expression pattern and similarity to the mammalian NRAMPs and a nitrate transporter in A.nidulans, the Mvl product may have a role in nitrite/nitrate transport.

        (Rodrigues et al., 1995)
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: Mvl CG3671

        (Gong, 1999.11)
        Nomenclature comments
        Etymology

        The gene name, coined by J. Chia, derives from the character Malvolio in Shakespeare's "Twelfth Night", who "taste(d) with distempered appetite".

        (Rodrigues et al., 1995)
        Synonyms and Secondary IDs (9)
        Reported As
        Symbol Synonym
        CG3671
        (Tang and Zhou, 2013, Hadar et al., 2012, Mandilaras and Missirlis, 2012, Mosallanejad et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)
        DMT1
        (Mohandas et al., 2017, Lang et al., 2012)
        Mvl
        (Soltani et al., 2025, Everman and Macdonald, 2024, Liu et al., 2024, Williams-Simon et al., 2024, Ye et al., 2024, Ceder and Fredriksson, 2022, Hall et al., 2021, Missirlis, 2021, Yu et al., 2021, Liu et al., 2020, Xue et al., 2020, Ben-Shahar, 2018, Calap-Quintana et al., 2018, Farkaš et al., 2018, Monnier et al., 2018, Calap-Quintana et al., 2017, Kline et al., 2017, Transgenic RNAi Project members, 2017-, Yoon et al., 2017, Soriano et al., 2016, Aradska et al., 2015, González-Morales et al., 2015, Zhu et al., 2014, Mandilaras et al., 2013, Short and Lazzaro, 2013, Southon et al., 2013, Tang and Zhou, 2013, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mandilaras and Missirlis, 2012, Bettedi et al., 2011, Jungreis et al., 2011, Maruyama et al., 2011, Bushati et al., 2008, Southon et al., 2008, Urasaki et al., 2008, Techau et al., 2007, Folwell et al., 2006, Orgad et al., 1998)
        NRM2
        (Mushegian et al., 1998)
        dNRAMP
        (Younes et al., 2020, Panda et al., 2013, Rose et al., 2011)
        mvl
        (Yankuzo et al., 2025, Ma et al., 2024, Ecovoiu et al., 2022, Shen and Cai, 2001, D'Souza et al., 1999, Nelson, 1999, Orgad et al., 1998, Reed et al., 1997, Cellier et al., 1995, Rodrigues et al., 1995)
        Name Synonyms
        /Divalent metal transporter
        (Mandilaras and Missirlis, 2012)
        Malvolio
        (Fasae and Abolaji, 2022, Green et al., 2022, Slobodian et al., 2021, Ben-Shahar, 2018, Farkaš et al., 2018, Zhu et al., 2014, Mandilaras et al., 2013, Tang and Zhou, 2013, Bettedi et al., 2011, Maruyama et al., 2008, Southon et al., 2008, Folwell et al., 2006)
        malvolio
        (Beckstead et al., 2007, Techau et al., 2007, Kimbrell and Beutler, 2001, Shen and Cai, 2001)
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 69 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (108)