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FB2021_03, released June 15, 2021

Gene: Dmel\Or35a

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General Information
Symbol
Dmel\Or35a
Species
D. melanogaster
Name
Odorant receptor 35a
Annotation Symbol
CG17868
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028946
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Odorant receptor 35a (Or35a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:BACR44L22.5 , 35a

Key Links
Genomic Location
Cytogenetic map
35D3-35D3
Sequence location
2L:15,622,068..15,623,558 [-]
Recombination map
2-51
RefSeq locus
NT_033779 REGION:15622068..15623558
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables olfactory receptor activity
inferred from high throughput direct assay
(Hallem and Carlson, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables odorant binding
inferred from sequence or structural similarity with FLYBASE:Or43b; FB:FBgn0026393
(FlyBase Curators, 2008--)
enables olfactory receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in detection of chemical stimulus involved in sensory perception of smell
inferred from high throughput direct assay
(Hallem and Carlson, 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in detection of chemical stimulus involved in sensory perception of smell
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from high throughput direct assay
(Hallem and Carlson, 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in dendrite membrane
inferred from sequence or structural similarity with FLYBASE:Or22a; FB:FBgn0026398
(FlyBase Curators, 2008--)
is_active_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily. (Q9V3Q2)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Odorant receptor 35a (Or35a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
ODORANT RECEPTORS -
Insect odorant receptors (ORs) are a family of chemoreceptors activated by volatile chemicals. ORs form heteromeric complexes, believed to function as non-selective cation channels, comprising an OR and the co-receptor Orco. ORs are expressed in the dendrites of subsets of olfactory neurons in the antenna and maxillary palp. (Adapted from FBrf0168007 and FBrf0220463).
Protein Function (UniProtKB)
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
(UniProt, Q9V3Q2)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Or35a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Possible pseudogene; RNA-Seq data inconsistent with gene model.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Or35a-RB
FBtr0080781
NM_165117
1290
409
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Or35a-PB
FBpp0080339
47.4
409
9.81
NP_723916
AAN10901
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.

(UniProt, Q9V3Q2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Or35a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult olfactory receptor neuron Or35a
(Couto et al., 2005)
neuron of antennal coeloconic sensillum ac3
(Benton et al., 2009)
Additional Descriptive Data

Or35a transcript is expressed in the antennal coeloconic sensillum ac3. In sensillum ac3 it is co-expressed with Ir75a, Ir75b, Orco and Ir76b.

(Benton et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of membrane
inferred from high throughput direct assay
(Hallem and Carlson, 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Or35a in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Or35a
Transgenic constructs containing regulatory region of Or35a
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7063
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
abnormal chemosensitive behavior
abnormal neurophysiology
abnormal smell perception, with Scer\GAL4Or22a.8197
Phenotype manifest in
Allele
olfactory sensory organ
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909IO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000919
Drosophila simulans
Dsim\GD21947
Drosophila erecta
Dere\GG24201
Drosophila yakuba
Dyak\GE19395
Drosophila ananassae
Dana\GF13895
Drosophila pseudoobscura pseudoobscura
Dpse\Or35a
Drosophila persimilis
Dper\GL26585
Drosophila willistoni
Dwil\GK18244
Drosophila virilis
Dvir\GJ23088
Drosophila mojavensis
Dmoj\GI22563
Drosophila grimshawi
Dgri\GH13109
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915051E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012163
Glossina morsitans
Tsetse fly
Gmor\GMOY012217
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00382
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (59)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Or74a
3 of 10
Or1a
2 of 10
Or2a
2 of 10
Or7a
2 of 10
Or9a
2 of 10
Or10a
2 of 10
Or13a
2 of 10
Or19a
2 of 10
Or19b
2 of 10
Or22a
2 of 10
Or22b
2 of 10
Or22c
2 of 10
Or23a
2 of 10
Or24a
2 of 10
Or30a
2 of 10
Or33a
2 of 10
Or33b
2 of 10
Or33c
2 of 10
Or42a
2 of 10
Or42b
2 of 10
Or43a
2 of 10
Or43b
2 of 10
Or45a
2 of 10
Or45b
2 of 10
Or46a
2 of 10
Or47a
2 of 10
Or47b
2 of 10
Or49a
2 of 10
Or49b
2 of 10
Or59a
2 of 10
Or59b
2 of 10
Or59c
2 of 10
Or63a
2 of 10
Or65a
2 of 10
Or65b
2 of 10
Or65c
2 of 10
Or67a
2 of 10
Or67b
2 of 10
Or67c
2 of 10
Or67d
2 of 10
Or69a
2 of 10
Or71a
2 of 10
Or82a
2 of 10
Or83c
2 of 10
Or85a
2 of 10
Or85b
2 of 10
Or85c
2 of 10
Or85d
2 of 10
Or85f
2 of 10
Or88a
2 of 10
Or92a
2 of 10
Or94a
2 of 10
Or94b
2 of 10
Or98a
2 of 10
Or56a
1 of 10
Or83a
1 of 10
Or85e
1 of 10
Or98b
1 of 10
Orco
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
    (UniProt, Q9V3Q2 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-51
    Cytogenetic map
    35D3-35D3
    Sequence location
    2L:15,622,068..15,623,558 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    35D3-35D3
    Limits computationally determined from genome sequence between P{EP}esgEP633&P{PZ}esg07082 and P{lacW}CycEk05007&P{lacW}CycEk02602
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-51

    (FlyBase, 2016)

    2-48.8

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (1)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: BG:BACR44L22.5 CG17868

              (Vosshall, 1999.11)
              Source for database merge of

              Source for merge of: Or35a BG:BACR44L22.5

              (Warr and Vosshall, 2000.5.19)
              Additional comments
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 22 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              DRscDB
              EMBL-EBI Single Cell Expression Atlas
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (91)