FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Snmp2
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General Information
Symbol
Dmel\Snmp2
Species
D. melanogaster
Name
Sensory neuron membrane protein 2
Annotation Symbol
CG7422
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035815
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Plays an olfactory role that is not restricted to pheromone sensitivity. (UniProt, E1JI63)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
66A11-66A11
Sequence location
Recombination map
3-21
RefSeq locus
NT_037436 REGION:7733250..7743041
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables scavenger receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000230217
(GO Reference Genome Project, 2011-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cellular response to pheromone
inferred from sequence or structural similarity with UniProtKB:Q9VDD3
(Gene Ontology Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000230217
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR002159
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the CD36 family. (E1JI63)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CLASS B SCAVENGER RECEPTORS -
Class B scavenger receptors are transmembrane proteins that belong to the CD36 family. These receptors contain two transmembrane domains, an extracellular loop with multiple glycosylation sites and two short intracellular tails. They are implicated in lipoprotein scavenging, fatty acid transport, innate immune signalling, cell adhesion, lysosomal protein sorting and gustatory fat detection. (Adapted from FBrf0232659.)
Protein Function (UniProtKB)
Plays an olfactory role that is not restricted to pheromone sensitivity.
(UniProt, E1JI63)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Snmp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry E1JI63)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Conservation across Dipteran species: supports merge.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Snmp2-RB
FBtr0110885
NM_001043128
2343
510
Snmp2-RC
FBtr0301205
NM_001169901
2481
556
Snmp2-RD
FBtr0334649
NM_001274610
2837
556
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Snmp2-PB
FBpp0110185
57.1
510
8.28
H0RNK6
NP_001036593
ABI31242
Snmp2-PC
FBpp0290423
62.6
556
9.03
E1JI63
NP_001163372
ACZ94643
Snmp2-PD
FBpp0306711
62.6
556
9.03
E1JI63
NP_001261539
AGB94234
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

556 aa isoforms: Snmp2-PC, Snmp2-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Snmp2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval anterior spiracle

Comment: 96 hr AEL

(Herboso et al., 2011)
wandering third instar larval stage -- third instar - cleared gut stage
testis

Comment: 96-120 hr AEL

(Herboso et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Snmp2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Snmp2
Transgenic constructs containing regulatory region of Snmp2
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\CD36
8 of 14
Yes
Yes
1  
Hsap\SCARB2
5 of 14
No
No
2  
Hsap\SCARB1
4 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\RGD1565355
7 of 14
Yes
Yes
Rnor\Cd36
5 of 14
No
Yes
Rnor\Scarb2
5 of 14
No
No
Rnor\LOC120093085
4 of 14
No
Yes
Rnor\Scarb1
4 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Cd36
8 of 14
Yes
Yes
Mmus\Scarb2
7 of 14
No
No
Mmus\Scarb1
4 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\cd36l
7 of 13
Yes
Yes
Xtro\cd36
7 of 13
Yes
Yes
Xtro\LOC100489067
6 of 13
No
Yes
Xtro\scarb2
4 of 13
No
No
Xtro\scarb1
3 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\cd36
9 of 14
Yes
Yes
Drer\scarb1
5 of 14
No
No
Drer\scarb2a
4 of 14
No
No
Drer\scarb2b
4 of 14
No
No
Drer\scarb2c
3 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\scav-1
5 of 14
Yes
No
Cele\scav-2
5 of 14
Yes
No
Cele\scav-3
5 of 14
Yes
No
Cele\scav-4
5 of 14
Yes
No
Cele\scav-5
5 of 14
Yes
No
Cele\scav-6
5 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\SCRB16
12 of 12
Yes
Yes
Agam\AgaP_AGAP012849
4 of 12
No
No
Agam\SCRB3
4 of 12
No
No
Agam\SCRB6
4 of 12
No
No
Agam\SCRB17
4 of 12
No
No
Agam\SCRBQ1
4 of 12
No
No
Agam\SCRBQ2
4 of 12
No
No
Agam\SCRBQ3
4 of 12
No
No
Agam\AgaP_AGAP004845
3 of 12
No
No
Agam\SCRB1
3 of 12
No
No
Agam\SCRB5
3 of 12
No
No
Agam\SCRB7
3 of 12
No
No
Agam\SCRB9
3 of 12
No
No
Agam\SCRB10
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Snmp2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
bez
6 of 13
CG7227
6 of 13
CG10345
6 of 13
CG31741
6 of 13
crq
6 of 13
dsb
6 of 13
emp
6 of 13
ninaD
6 of 13
pes
6 of 13
santa-maria
6 of 13
CG2736
5 of 13
CG40006
5 of 13
Snmp1
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CD36; CD36 molecule (CD36 blood group)
    model of  platelet-type bleeding disorder 10
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CD36; CD36 molecule (CD36 blood group)
    8 of 14
    173510
     
    SCARB2; scavenger receptor class B member 2
    5 of 14
    602257
     
    SCARB1; scavenger receptor class B member 1
    4 of 14
    601040
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-21
      Cytogenetic map
      66A11-66A11
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      66A11-66A11
      Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-21

      (FlyBase, 2016)

      3-17.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (19)
      cDNA Clones (22)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Annotation CG16832 was eliminated in release 3 of the genome annotation, October 2002.

            (FlyBase Genome Annotators, 2002-2003)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: CG7422 CG16832

            (FlyBase Genome Annotators, 2006)
            Additional comments

            Release 2 annotation CG16832 (which was eliminated in release 3 of the genome annotation) has been merged with CG7422 in release 5.1 of the genome annotation.

            (FlyBase Genome Annotators, 2006)
            Nomenclature History
            Source for database identify of

            Source for identity of: Snmp2 CG7422

            (Vogt et al., 2009)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (7)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 40 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            References (37)