FB2021_01, released Feb 18, 2021

Gene: Dmel\CG5535

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General Information
Symbol
Dmel\CG5535
Species
D. melanogaster
Name
Annotation Symbol
CG5535
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036764
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
75A4-75A4
Sequence location
3L:17,852,624..17,856,794 [-]
Recombination map

3-45

RefSeq locus
NT_037436 REGION:17852624..17856794
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables amino acid transmembrane transporter activity
inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439
(Romero-Calderon et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN001718573
(assigned by GO_Central )
(Gaudet et al., 2011)
enables arginine transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000208312
(assigned by GO_Central )
(Gaudet et al., 2011)
enables L-lysine transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000208312
(assigned by GO_Central )
(Gaudet et al., 2011)
enables L-ornithine transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000208312
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in amino acid transmembrane transport
inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439
(Romero-Calderon et al., 2007)
involved_in amino acid transport
inferred from biological aspect of ancestor with PANTHER:PTN001718573
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in L-arginine import across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000208312
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in L-ornithine transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000208312
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000926816
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CATIONIC AMINO ACID TRANSPORTERS -
Members of the cationic amino acid transporters (CATs) transport cationic amino acids by facilitated diffusion across membranes. (Adapted from FBrf0207965 and PMID:14770310).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG5535 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG5535-RB
FBtr0075159
NM_168753
2147
621
CG5535-RC
FBtr0273277
NM_140762
2040
630
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG5535-PB
FBpp0074925
67.8
621
9.05
NP_730312
AAF49292
CG5535-PC
FBpp0271785
68.9
630
8.68
NP_649019
AAF49291
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG5535 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head | faint
(Romero-Calderon et al., 2007)
adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG5535 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG5535
Transgenic constructs containing regulatory region of CG5535
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC7A1
11 of 15
Yes
No
Hsap\SLC7A3
11 of 15
Yes
No
Hsap\SLC7A2
10 of 15
No
No
Hsap\SLC7A4
6 of 15
No
No
Hsap\SLC7A14
4 of 15
No
No
Hsap\SLC7A5
2 of 15
No
No
Hsap\SLC7A6
2 of 15
No
No
Hsap\SLC7A7
2 of 15
No
No
Hsap\SLC7A8
2 of 15
No
No
Hsap\SLC7A9
2 of 15
No
No
Hsap\SLC7A10
2 of 15
No
No
Hsap\SLC7A11
2 of 15
No
No
Hsap\SLC7A13
2 of 15
No
No
Hsap\SLC12A1
1 of 15
No
No
Hsap\SLC12A2
1 of 15
No
No
1  
Hsap\SLC12A3
1 of 15
No
No
Hsap\SLC12A4
1 of 15
No
No
1  
Hsap\SLC12A5
1 of 15
No
No
2  
Hsap\SLC12A6
1 of 15
No
No
Hsap\SLC12A7
1 of 15
No
No
Hsap\SLC12A8
1 of 15
No
No
Hsap\SLC12A9
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (25)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc7a1
12 of 15
Yes
Yes
Mmus\Slc7a2
11 of 15
No
Yes
Mmus\Slc7a3
11 of 15
No
No
Mmus\AU018091
10 of 15
No
Yes
Mmus\Slc7a4
5 of 15
No
No
Mmus\Slc7a14
3 of 15
No
No
Mmus\Slc7a5
2 of 15
No
No
Mmus\Slc7a6
2 of 15
No
No
Mmus\Slc7a7
2 of 15
No
No
Mmus\Slc7a8
2 of 15
No
No
Mmus\Slc7a9
2 of 15
No
No
Mmus\Slc7a10
2 of 15
No
No
Mmus\Slc7a11
2 of 15
No
No
Mmus\Slc7a12
2 of 15
No
No
Mmus\Slc7a13
2 of 15
No
No
Mmus\Slc7a15
2 of 15
No
No
Mmus\Slc12a1
1 of 15
No
No
Mmus\Slc12a2
1 of 15
No
No
Mmus\Slc12a3
1 of 15
No
No
Mmus\Slc12a4
1 of 15
No
No
Mmus\Slc12a5
1 of 15
No
No
Mmus\Slc12a6
1 of 15
No
No
Mmus\Slc12a7
1 of 15
No
No
Mmus\Slc12a8
1 of 15
No
No
Mmus\Slc12a9
1 of 15
No
No
Rattus norvegicus (Norway rat) (24)
Rnor\Slc7a1
11 of 13
Yes
No
Rnor\Slc7a3
9 of 13
No
No
Rnor\Slc7a2
8 of 13
No
No
Rnor\LOC292543
5 of 13
No
No
Rnor\Slc7a4
5 of 13
No
No
Rnor\Slc7a14
3 of 13
No
No
Rnor\LOC361914
2 of 13
No
No
Rnor\LOC688389
2 of 13
No
No
Rnor\Slc7a5
2 of 13
No
No
Rnor\Slc7a6
2 of 13
No
No
Rnor\Slc7a7
2 of 13
No
No
Rnor\Slc7a8
2 of 13
No
No
Rnor\Slc7a9
2 of 13
No
No
Rnor\Slc7a10
2 of 13
No
No
Rnor\Slc7a11
2 of 13
No
No
Rnor\Slc7a12
2 of 13
No
No
Rnor\Slc7a13
2 of 13
No
No
Rnor\Slc7a15
2 of 13
No
No
Rnor\Slc12a1
1 of 13
No
No
Rnor\Slc12a2
1 of 13
No
No
Rnor\Slc12a4
1 of 13
No
No
Rnor\Slc12a6
1 of 13
No
No
Rnor\Slc12a7
1 of 13
No
No
Rnor\Slc12a8
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\slc7a1
7 of 12
Yes
No
Xtro\slc7a2.1
6 of 12
No
No
Xtro\slc7a2.2
6 of 12
No
No
Xtro\slc7a3
6 of 12
No
No
Xtro\slc7a4
4 of 12
No
No
Xtro\slc7a14
3 of 12
No
No
Xtro\LOC100492274
2 of 12
No
No
Xtro\slc7a5
2 of 12
No
No
Xtro\slc7a6
2 of 12
No
No
Xtro\slc7a7
2 of 12
No
No
Xtro\slc7a8
2 of 12
No
No
Xtro\slc7a9
2 of 12
No
No
Xtro\slc7a10
2 of 12
No
No
Xtro\slc7a11
2 of 12
No
No
Xtro\slc7a13
2 of 12
No
No
Xtro\slc7a15
2 of 12
No
No
Xtro\slc12a1
1 of 12
No
No
Xtro\slc12a3
1 of 12
No
No
Xtro\slc12a4
1 of 12
No
No
Xtro\slc12a6
1 of 12
No
No
Xtro\slc12a9
1 of 12
No
No
Danio rerio (Zebrafish) (34)
Drer\slc7a1a
12 of 15
Yes
No
Drer\slc7a3b
11 of 15
No
No
Drer\slc7a3a
10 of 15
No
No
Drer\slc7a2
9 of 15
No
No
Drer\slc7a1b
7 of 15
No
No
Drer\slc7a4
6 of 15
No
No
Drer\zgc:175280
5 of 15
No
No
Drer\slc7a14a
4 of 15
No
No
Drer\slc7a14b
4 of 15
No
No
Drer\si:ch73-352p4.8
2 of 15
No
No
Drer\slc7a5
2 of 15
No
No
Drer\slc7a6
2 of 15
No
No
Drer\slc7a7
2 of 15
No
No
Drer\slc7a8a
2 of 15
No
No
Drer\slc7a8b
2 of 15
No
No
Drer\slc7a10a
2 of 15
No
No
Drer\slc7a10b
2 of 15
No
No
Drer\slc7a11
2 of 15
No
No
Drer\zmp:0000001267
2 of 15
No
No
Drer\si:cabz01090193.1
1 of 15
No
No
Drer\si:ch211-59d13.2
1 of 15
No
No
Drer\si:dkeyp-120h9.1
1 of 15
No
No
Drer\slc7a9
1 of 15
No
No
Drer\slc12a1
1 of 15
No
No
Drer\slc12a4
1 of 15
No
No
Drer\slc12a5b
1 of 15
No
No
Drer\slc12a7a
1 of 15
No
No
Drer\slc12a7b
1 of 15
No
No
Drer\slc12a8
1 of 15
No
No
Drer\slc12a9
1 of 15
No
No
Drer\slc12a10.1
1 of 15
No
No
Drer\slc12a10.2
1 of 15
No
No
Drer\slc12a10.3
1 of 15
No
No
Drer\zgc:153039
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (20)
Cele\B0454.6
5 of 15
Yes
No
Cele\F23F1.6
5 of 15
Yes
No
Cele\C50D2.2
4 of 15
No
No
Cele\Y53F4B.12
4 of 15
No
Yes
Cele\aat-4
2 of 15
No
No
Cele\aat-5
2 of 15
No
No
Cele\aat-9
2 of 15
No
No
Cele\aat-1
1 of 15
No
No
Cele\aat-2
1 of 15
No
No
Cele\aat-3
1 of 15
No
No
Cele\aat-6
1 of 15
No
No
Cele\aat-7
1 of 15
No
No
Cele\aat-8
1 of 15
No
No
Cele\B0303.11
1 of 15
No
No
Cele\F10E7.9
1 of 15
No
No
Cele\kcc-1
1 of 15
No
No
Cele\kcc-2
1 of 15
No
No
Cele\kcc-3
1 of 15
No
No
Cele\nkcc-1
1 of 15
No
No
Cele\T04B8.5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\CAT4
7 of 9
Yes
No
Atha\CAT2
6 of 9
No
No
Atha\CAT3
6 of 9
No
No
Atha\CAT9
4 of 9
No
No
Atha\AAT1
3 of 9
No
No
Atha\CAT5
3 of 9
No
No
Atha\CAT8
3 of 9
No
No
Atha\CAT6
2 of 9
No
No
Atha\CAT7
2 of 9
No
No
Atha\BAT1
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (25)
Scer\AGP3
4 of 15
Yes
Yes
Scer\BAP3
4 of 15
Yes
No
Scer\HIP1
4 of 15
Yes
No
Scer\AGP1
3 of 15
No
Yes
Scer\ALP1
3 of 15
No
Yes
Scer\BAP2
3 of 15
No
No
Scer\CAN1
3 of 15
No
Yes
Scer\GAP1
3 of 15
No
Yes
Scer\GNP1
3 of 15
No
No
Scer\MMP1
3 of 15
No
No
Scer\SAM3
3 of 15
No
Yes
Scer\UGA4
3 of 15
No
Yes
Scer\AGP2
2 of 15
No
Yes
Scer\DIP5
2 of 15
No
Yes
Scer\LYP1
2 of 15
No
Yes
Scer\PUT4
2 of 15
No
Yes
Scer\SSY1
2 of 15
No
Yes
Scer\TAT1
2 of 15
No
No
Scer\TAT2
2 of 15
No
Yes
Scer\BIO5
1 of 15
No
Yes
Scer\HNM1
1 of 15
No
Yes
Scer\MUP1
1 of 15
No
No
Scer\MUP3
1 of 15
No
No
Scer\TPO5
1 of 15
No
Yes
Scer\VHC1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (11)
Spom\SPCPB1C11.02
3 of 12
Yes
Yes
Spom\isp5
2 of 12
No
Yes
Spom\SPCC584.13
2 of 12
No
Yes
Spom\SPCC965.11c
2 of 12
No
Yes
Spom\cat1
1 of 12
No
Yes
Spom\per1
1 of 12
No
No
Spom\SPAC1039.01
1 of 12
No
No
Spom\SPAPB24D3.02c
1 of 12
No
No
Spom\SPBC1652.02
1 of 12
No
Yes
Spom\SPBPB2B2.01
1 of 12
No
No
Spom\SPCC74.04
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904BO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD12366
Drosophila sechellia
Dsec\GM24297
Drosophila erecta
Dere\GG15772
Drosophila yakuba
Dyak\GE22107
Drosophila ananassae
Dana\GF25230
Drosophila pseudoobscura pseudoobscura
Dpse\GA18954
Drosophila persimilis
Dper\GL22741
Drosophila willistoni
Dwil\GK20579
Drosophila virilis
Dvir\GJ26811
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502YO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022503
Glossina morsitans
Tsetse fly
Gmor\GMOY002308
Mayetiola destructor
Hessian fly
Mdes\Mdes004518
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08OC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA014238
Bombyx mori
Silkmoth
Bmor\BGIBMGA014266
Bombyx mori
Silkmoth
Bmor\BGIBMGA014265
Danaus plexippus
Monarch butterfly
Dple\DPOGS201195-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201194-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201174-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL018011
Heliconius melpomene
Postman butterfly
Hmel\HMEL018014
Apis florea
Little honeybee
Aflo\2727405140
Apis florea
Little honeybee
Aflo\2226385828
Apis mellifera
Western honey bee
Amel\GB43098
Apis mellifera
Western honey bee
Amel\GB46448
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23019
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22837
Bombus terrestris
Buff-tailed bumblebee
Bter\15210491
Bombus terrestris
Buff-tailed bumblebee
Bter\15214202
Linepithema humile
Argentine ant
Lhum\LH12669
Linepithema humile
Argentine ant
Lhum\LH11005
Linepithema humile
Argentine ant
Lhum\LH22022
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000e1e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000af
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010226
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006689
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07333
Tribolium castaneum
Red flour beetle
Tcas\TC001941
Tribolium castaneum
Red flour beetle
Tcas\TC034265
Pediculus humanus
Human body louse
Phum\PHUM258130
Pediculus humanus
Human body louse
Phum\PHUM169840
Rhodnius prolixus
Kissing bug
Rpro\RPRC015423
Rhodnius prolixus
Kissing bug
Rpro\RPRC004799
Cimex lectularius
Bed bug
Clec\CLEC003171
Cimex lectularius
Bed bug
Clec\CLEC000649
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005118
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003923
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008904
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005156
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003240
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003523
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005472
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008323
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002633
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000584
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00743
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00747
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X083W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005129
Strigamia maritima
European centipede
Smar\SMAR001724
Strigamia maritima
European centipede
Smar\SMAR005136
Ixodes scapularis
Black-legged tick
Isca\ISCW023458
Ixodes scapularis
Black-legged tick
Isca\ISCW007095
Ixodes scapularis
Black-legged tick
Isca\ISCW001425
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68025.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59748.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73640.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75452.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g12290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g07880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur30g00540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g01010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g07990
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_21886
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_46947
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_236331
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05NM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a4_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a4_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a14_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a4_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc7a4_1
Ciona intestinalis
Vase tunicate
Cint\LOC100187499
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000017277
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007337
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009305
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004391
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022693
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019724
Gallus gallus
Domestic chicken
Ggal\SLC7A4
Gallus gallus
Domestic chicken
Ggal\SLC7A1
Gallus gallus
Domestic chicken
Ggal\SLC7A14
Gallus gallus
Domestic chicken
Ggal\SLC7A3
Gallus gallus
Domestic chicken
Ggal\SLC7A2
Gallus gallus
Domestic chicken
Ggal\LOC770309
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
slif
10 of 10
CG7255
8 of 10
CG13248
7 of 10
CG12531
6 of 10
CG1607
2 of 10
mnd
2 of 10
sbm
2 of 10
tadr
2 of 10
CG10413
1 of 10
CG12773
1 of 10
gb
1 of 10
JhI-21
1 of 10
kcc
1 of 10
Ncc69
1 of 10
NKCC
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC7A1; solute carrier family 7 member 1
    11 of 15
    104615
        SLC7A3; solute carrier family 7 member 3
        11 of 15
        300443
            SLC7A2; solute carrier family 7 member 2
            10 of 15
            601872
                SLC7A4; solute carrier family 7 member 4
                6 of 15
                603752
                    SLC7A14; solute carrier family 7 member 14
                    4 of 15
                    615720
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Interactions Browser
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Linkouts
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3L
                    Recombination map

                    3-45

                    Cytogenetic map
                    75A4-75A4
                    Sequence location
                    3L:17,852,624..17,856,794 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    75A4-75A4
                    Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-45

                    (FlyBase, 2016)

                    3-41.2

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (8)
                    Genomic Clones (17)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (11)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of

                    Source for merge of: CG5535 anon-WO0118547.111

                    (FlyBase, 1996-)
                    Additional comments

                    Source for merge of CG5535 anon-WO0118547.111 was sequence comparison ( date:051113 ).

                    (FlyBase, 1996-)
                    Other Comments

                    Area matching Drosophila EST AA979454 (inverted). This EST has sequence similarity to human REC1L , Acc. No. X57303.

                    (Davies, 2001.3.15)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 38 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (2)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (38)