FlyBase Gene Report: Dmel\wkd

General Information

Symbol

Dmel\wkd

Species

D. melanogaster

Name

whacked

Annotation Symbol

CG5344

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037917

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

whacked (wkd) encodes a RabGAP that catalyzes the GTPase activity of its Rab-GTP partners. Its essential substrate appears to be the product of Rab35. wkd mutations are associated with seamless tube defects in the tracheal system. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

86E11-86E11

Sequence location

3R:11,581,576..11,585,305 [+]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11581576..11585305

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables GTPase activator activity

inferred from sequence or structural similarity with FLYBASE:Evi5; FB:FBgn0262740

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000537561

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in lumen formation, open tracheal system

inferred from mutant phenotype

(Schottenfeld-Roames and Ghabrial, 2012)

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

involved_in polarity specification of proximal/distal axis

inferred from mutant phenotype

(Schottenfeld-Roames and Ghabrial, 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in retrograde transport, endosome to Golgi

inferred from biological aspect of ancestor with PANTHER:PTN001120419

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoplasmic side of apical plasma membrane

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

located_in cytoplasm

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

located_in filopodium

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RAB GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

RAB GTPASE ACTIVATING PROTEINS -: RabGAPs are GTPase activating proteins for Rab family GTPases. RabGAPs share a common TBC (Tre-2/Bub2/Cdc16) domain. (Adapted from PMID:15731001 and FBrf0158741).

Protein Function (UniProtKB)

Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.

(UniProt, Q9VGL8)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\wkd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VGL8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

wkd-RA

FBtr0082413

NM_141832

2054

363

wkd-RB

FBtr0082414

NM_169402

2119

363

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

wkd-PA

FBpp0081889

42.1

363

9.59

FBpp0081890

42.1

363

9.59

Q9VGL8

NP_731593

AAN13513

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

363 aa isoforms: wkd-PA, wkd-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VGL8

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wkd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wkd_1
wkd_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.36

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

garland cell primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasmic side of apical plasma membrane

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

located_in cytoplasm

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

located_in filopodium

inferred from direct assay

(Schottenfeld-Roames and Ghabrial, 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\wkd in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\wkd

View exonic expression by tissue for Dmel\wkd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037917

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41390/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037917

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037917

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037917

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5344

Flygut - An atlas of the Drosophila adult midgut

FBgn0037917

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\wkd

Stages(s) 1-3
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of wkd

Transgenic constructs containing regulatory region of wkd

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6161

(Ryder, 2004.4.26)

Df(3R)Exel6276

(Ghabrial et al., 2011, Ryder, 2004.4.26)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(3R)Exel6276)

lethal - all die before end of P-stage

wkd²²⁰

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wkd^GD11617

viable, with Scer\GAL4^Mef2.PR

wkd^GD11617

viable, with Scer\GAL4^pnr-MD237

wkd^GD11617

viable, with Scer\GAL4^tin.CΔ4

wkd^GD11617

Other Phenotypes

Allele

some die during pharate adult stage

wkd²²⁰

Phenotype manifest in

Allele

eye | somatic clone

larval tracheal system

terminal tracheal cell

terminal tracheal cell, with Scer\GAL4^btl.PS

wkd^UAS.cSa

terminal tracheal cell (with Df(3R)Exel6276)

terminal tracheal cell | somatic clone

wkd²²⁰

tracheal fusion cell | somatic clone

wkd²²⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (53)

Hsap\TBC1D10A

11 of 14

Yes

Hsap\TBC1D10C

11 of 14

Yes

Hsap\TBC1D10B

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\TBC1D13

2 of 14

Hsap\TBC1D14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Tbc1d10a

11 of 14

Yes

Rnor\Tbc1d10c

11 of 14

Yes

Rnor\Tbc1d10b

10 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (38)

Mmus\Tbc1d10a

10 of 14

Yes

Mmus\Tbc1d10c

10 of 14

Yes

Mmus\Tbc1d10b

9 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Tbc1d13

2 of 14

Mmus\Tbc1d14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\tbc1d10b

7 of 13

Yes

Xtro\tbc1d10a

6 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (44)

Drer\tbc1d10ab

10 of 14

Yes

Drer\tbc1d10aa

9 of 14

Yes

Drer\tbc1d10b

7 of 14

Yes

Drer\tbc1d10c

5 of 14

Yes

Drer\si:ch211-266k8.4

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-288d18.1

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\tbc1d14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-15d5.11

1 of 14

Drer\si:dkey-238d18.4

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\tbc-10

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP001953

12 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (25)

Atha\PAM1

7 of 13

Yes

5 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\GYL1

2 of 13

Yes

Scer\GYP5

2 of 13

Yes

Scer\GYP7

2 of 13

Yes

Scer\MDR1

2 of 13

Yes

Scer\MSB3

2 of 13

Yes

Scer\MSB4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (12)

Spom\SPBC1778.09

6 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Spom\SPAC1952.17c

2 of 12

Spom\SPBC215.01

2 of 12

Spom\SPCC1620.12c

2 of 12

Yes

Spom\cdc16

1 of 12

Spom\gyp1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:wkd. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

8 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

plx

3 of 13

Tbc1d22

3 of 13

tbc

3 of 13

CG4041

2 of 13

CG3703

1 of 13

GstT3

1 of 13

mtd

1 of 13

sky

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TBC1D10A; TBC1 domain family member 10A

11 of 14

610020

TBC1D10C; TBC1 domain family member 10C

11 of 14

610831

TBC1D10B; TBC1 domain family member 10B

10 of 14

613620

TBC1D3C; TBC1 domain family member 3C

3 of 14

610806

TBC1D3D; TBC1 domain family member 3D

3 of 14

610807

TBC1D3E; TBC1 domain family member 3E

3 of 14

610808

TBC1D3G; TBC1 domain family member 3G

3 of 14

610810

TBC1D3H; TBC1 domain family member 3H

3 of 14

610811

TBC1D3; TBC1 domain family member 3

3 of 14

607741

TBC1D3I; TBC1 domain family member 3I

3 of 14

TBC1D3K; TBC1 domain family member 3K

3 of 14

TBC1D3L; TBC1 domain family member 3L

3 of 14

TBC1D26; TBC1 domain family member 26

3 of 14

USP6NL; USP6 N-terminal like

3 of 14

605405

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

wkd

suppressible

Rab35

(Schottenfeld-Roames and Ghabrial, 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66518

DroID - A comprehensive database of gene and protein interactions.

FBgn0037917

MIST (protein-protein) - An integrated Molecular Interaction Database

41390

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

86E11-86E11

Sequence location

3R:11,581,576..11,585,305 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86E11-86E11

Limits computationally determined from genome sequence between P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵ and P{EP}Lk6^EP886

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Location based on deficiency mapping with Df(3R)Exel6276.

(Ghabrial et al., 2011)

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24206

w¹¹¹⁸; Mi{ET1}wkd^MB04624

84049

y¹ sc^* v¹ sev²¹; P{TKO.GS04469}attP40

77447

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06579}attP40

63108

w^*; P{GAL4-btl.S}2, P{UASp-Act5C.T:GFP}2; P{FRT(w^hs)}2A P{neoFRT}82B wkd²²⁰/TM3, P{tubP-GAL80}3, Sb¹

NIG-Fly

5344R-2

P{NIG.5344R}2

VDRC

v22081

w¹¹¹⁸ P{GD11617}v22081

v22082

w¹¹¹⁸; P{GD11617}v22082

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (71)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE26521

Other clones

DPiM_RE26521

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037917

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037917

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

May be required for tracheal terminal cell growth and branching.

(Ghabrial et al., 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: the insertion in the "e01976" Exelixis line (PBac{RB}CG5342^e01976) was originally assigned to the wkd gene in FBrf0179797, resulting in the "wkd^e01976" (FBal0161289) allele. However, FBrf0182831 shows that the insertion is actually within CG5342.

(Bloomington Drosophila Stock Center, 2004.11.6)

Nomenclature History

Source for database identify of

Source for identity of: wkd CG5344

(Ghabrial, 2005.3.2)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Name Synonyms

Whacked

(Schottenfeld-Roames et al., 2014, Laflamme et al., 2012, Schottenfeld-Roames and Ghabrial, 2012)

whacked

(Camelo and Luschnig, 2021, Schottenfeld-Roames and Ghabrial, 2012, Ghabrial et al., 2011, Ghabrial, 2005.3.2, Ghabrial et al., 2005)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41390

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VGL8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VGL8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VGL8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037917

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41390/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037917

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037917

FlyMine - An integrated database for Drosophila genomics

FBgn0037917

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5344

MARRVEL_MODEL - MARRVEL (model organism gene)

41390

Linkouts

BioGRID - A database of protein and genetic interactions.

66518

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037917

DroID - A comprehensive database of gene and protein interactions.

FBgn0037917

DRSC - Results frm RNAi screens

FBgn0037917

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wkd_1
wkd_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037917

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037917

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5344

Flygut - An atlas of the Drosophila adult midgut

FBgn0037917

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037917

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015650

MIST (protein-protein) - An integrated Molecular Interaction Database

41390

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (43)

The following external sites may use different assemblies or annotations than FlyBase.

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