Gene model reviewed during 5.39
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\BigH1 using the Feature Mapper tool.
BigH1 expression is is successively turned on and off during spermatogenesis. It is expressed in the tip region of the testis, becomes undetectable during the transit-amplifying spermatogonial divisions, strongly increases in spermatocytes and then is shut off in spermatids. Expression is germ cell-specific and it strong in the germline stem cells anchored to the hub.
BigH1 levels are high in 1-3 hr embryos and then decline. BigH1 protein is observed in primordial germline cells as they migrate during embryonic development. It is observed in spermatocytes in the testis and is found in the oocyte and then later in nurse cells proximal to the oocyte in the ovary.
GBrowse - Visual display of RNA-Seq signalsView Dmel\BigH1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: BigH1 CG3509
BigH1 encodes an early embryonic and germline-specific variant of Histone H1. BigH1 protein is abundant prior to cellularisation. Upon cellularisation, BigH1 is replaced by somatic His1 in the soma, but not in the primordial germ cells. BigH1 prevents premature zygotic genome activation in both the soma and the germline.