capa-1, CAP2b, capa-2, capa-3, Drm-PK-1
Gene model reviewed during 5.44
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Capa using the Feature Mapper tool.
Capa is expressed in the peptidergic CC-MS 2 neurons in the larval brain and in the Va neurons of the abdominal ventral nerve cord.
Three pairs of Va neurons in abdominal ganglia are immunoreactive for Capa. The processes of the first two Va neuron pairs do not exit the ventral ganglio,n but run anterior underneath the dorsal neural sheath in an individually varying pattern, and terminate in the thoracic ganglia. The neurites of the most posterior Va pair fasciculate and leave the ganglion posteriorly.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Capa in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The "capa-1" and "capa-2" peptides encoded by capa increase fluid secretion rates, stimulate nitric oxide production and elevate intracellular Ca2+ and cGMP in principal cells in the Malpighian tubule. The actions of capa-1" and "capa-2" are not synergistic.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
The gene is named "capability" because it clearly has the ability to encode two neuropeptides of the CAP[[2b]] family.