FlyBase Gene Report: Dmel\Syt7

General Information

Symbol

Dmel\Syt7

Species

D. melanogaster

Name

Synaptotagmin 7

Annotation Symbol

CG2381

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039900

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

neuromuscular junction - a calcium sensor that suppresses vesicle release - loss of Syt7 converts the normally observed synaptic facilitation response during repetitive stimulation into synaptic depression (Interactive Fly, Syt7 )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Syt VII

Key Links

Genomic Location

Cytogenetic map

102B3-102B3

Sequence location

4:278,685..306,481 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:278685..306481

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium ion sensor activity

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

enables calcium-dependent phospholipid binding

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR037732

(InterPro Project Members, 2004-)

enables SNARE binding

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in regulation of synaptic vesicle exocytosis

inferred from mutant phenotype

(Guan et al., 2020)

inferred from direct assay

(Guan et al., 2020)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in calcium-dependent activation of synaptic vesicle fusion

inferred from biological aspect of ancestor with PANTHER:PTN004120656

(GO Reference Genome Project, 2011-)

involved_in regulation of calcium ion-dependent exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle exocytosis

inferred from sequence or structural similarity

(Littleton, 2000)

involved_in vesicle fusion

inferred from biological aspect of ancestor with PANTHER:PTN001597973

(GO Reference Genome Project, 2011-)

involved_in vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

Cellular Component (11 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

colocalizes_with lysosome

inferred from direct assay

(Saraswati et al., 2007)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Guan et al., 2020)

inferred from direct assay

(Guan et al., 2020)

located_in sarcoplasm

inferred from direct assay

(Adolfsen et al., 2004)

is_active_in synaptic membrane

inferred from mutant phenotype

(Guan et al., 2020)

inferred from direct assay

(Guan et al., 2020)

located_in vesicle

inferred from direct assay

(Adolfsen et al., 2004)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN004120656

(GO Reference Genome Project, 2011-)

is_active_in exocytic vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR001565

(InterPro Project Members, 2004-)

inferred from sequence model

(FlyBase Curators, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000001283

(GO Reference Genome Project, 2011-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN004120656

(GO Reference Genome Project, 2011-)

located_in synaptic vesicle

inferred from sequence or structural similarity

(Littleton, 2000)

Gene Group (FlyBase)

SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS -: Synaptotagmins are a family of membrane-trafficking proteins characterized by an N-terminal transmembrane region and tandem cytoplasmic C2 domains which mediate specific interactions. Some of the family can interact with lipids in a Ca²⁺-dependent manner, leading to Ca²⁺-regulated release of neurotransmitters and hormones in the nervous and endocrine system. (Adapted from PMID:24065953 and FBrf0210023).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Syt7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V4C4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.53

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; short-capped RNA data, FBrf0209722). May be specific to sequenced strain; not included in gene model.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Syt7-RA

FBtr0089137

NM_166748

2794

416

Syt7-RB

FBtr0089134

NM_166749

2684

327

Syt7-RF

FBtr0089139

NM_205871

3002

283

Syt7-RI

FBtr0305658

NM_001258488

2596

345

Syt7-RM

FBtr0343990

NM_166751

2830

416

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Syt7-PA

FBpp0088205

46.9

416

9.41

FBpp0088202

36.7

327

9.42

FBpp0089328

32.8

283

9.32

FBpp0296938

38.6

345

9.70

FBpp0310439

46.9

416

9.41

Q9V4C4

NP_726560

AAN06525

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

416 aa isoforms: Syt7-PA, Syt7-PM

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Syt7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with lysosome

inferred from direct assay

(Saraswati et al., 2007)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Guan et al., 2020)

inferred from direct assay

(Guan et al., 2020)

located_in sarcoplasm

inferred from direct assay

(Adolfsen et al., 2004)

is_active_in synaptic membrane

inferred from mutant phenotype

(Guan et al., 2020)

inferred from direct assay

(Guan et al., 2020)

located_in vesicle

inferred from direct assay

(Adolfsen et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Syt7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Syt7

View exonic expression by tissue for Dmel\Syt7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43783/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039900

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039900

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039900

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2381

Flygut - An atlas of the Drosophila adult midgut

FBgn0039900

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Syt7

Transgenic constructs containing regulatory region of Syt7

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene partially duplicated in

Dp(4;4)6-M397

(Sun et al., 2004)

Gene disrupted in

Df(4)B2-2d

(Podemski et al., 2004)

Df(4)BH

(Schinaman et al., 2014)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Syt7^6-M193

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Syt7^GD8644

viable, with Scer\GAL4^Mef2.PR

Syt7^GD8644

viable, with Scer\GAL4^pnr-MD237

Syt7^GD8644

viable, with Scer\GAL4^tin.CΔ4

Syt7^GD8644

Sterility

Allele

female fertile

Syt7^B

female fertile (with Df(4)ED6369)

Syt7^B

Other Phenotypes

Allele

abnormal neurophysiology | larval stage, with Scer\GAL4^elav-C155

Syt7^UAS.CFP

abnormal neurophysiology | larval stage | semidominant

Syt7^M1

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | larval stage

Syt7^M1

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

Syt7^UAS.CFP

t-bar | larval stage

Syt7^M1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (80)

Hsap\SYT7

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CPNE2

1 of 14

Yes

Hsap\CPNE3

1 of 14

Yes

Hsap\CPNE4

1 of 14

Yes

Hsap\CPNE5

1 of 14

Yes

Hsap\CPNE6

1 of 14

Yes

Hsap\CPNE7

1 of 14

Yes

Hsap\CPNE8

1 of 14

Yes

Hsap\CPNE9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PLA2G4D

1 of 14

Hsap\PLA2G4F

1 of 14

Yes

Hsap\PRF1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (41)

Rnor\Syt7

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (43)

Mmus\Syt7

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (50)

Xtro\syt7

6 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

Xtro\syt11

3 of 13

Yes

Xtro\syt15

3 of 13

Yes

Xtro\syt17

3 of 13

Xtro\doc2b

2 of 13

Xtro\LOC100496796

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cpne9

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\unc13c

1 of 13

Danio rerio (Zebrafish) (69)

Drer\syt7a

11 of 14

Yes

Drer\syt7b

10 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\doc2a

2 of 14

Drer\doc2d

2 of 14

Drer\LOC101884989

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\myof

1 of 14

Drer\myofl

1 of 14

Drer\pla2g4ab

1 of 14

Yes

Drer\prf1.2

1 of 14

Yes

Drer\prf1.3

1 of 14

Yes

Drer\prf1.5

1 of 14

Yes

Drer\prf1.6

1 of 14

Yes

Drer\prf1.7

1 of 14

Yes

Drer\prf1.8

1 of 14

Yes

Drer\rasa3

1 of 14

Drer\rph3aa

1 of 14

Drer\si:ch211-240l19.5

1 of 14

Yes

Drer\si:ch211-240l19.6

1 of 14

Yes

Drer\si:ch211-240l19.7

1 of 14

Yes

Drer\si:ch211-240l19.8

1 of 14

Yes

Drer\si:ch211-266g18.6

1 of 14

Drer\syt8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (26)

Cele\snt-6

7 of 14

Yes

Cele\snt-2

4 of 14

Cele\DH11.5

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Cele\mctp-1

2 of 14

Cele\cnt-1

1 of 14

Cele\cpna-1

1 of 14

Yes

Cele\cpna-2

1 of 14

Yes

Cele\cpna-3

1 of 14

Yes

Cele\cpna-4

1 of 14

Yes

Cele\cpna-5

1 of 14

Yes

Cele\D2023.3

1 of 14

Cele\esyt-2

1 of 14

Cele\gem-4

1 of 14

Yes

Cele\nra-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP001800

4 of 12

Yes

Agam\AgaP_AGAP007942

4 of 12

Yes

Agam\AgaP_AGAP008650

4 of 12

Yes

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012088

1 of 12

Agam\AgaP_AGAP012252

1 of 12

Arabidopsis thaliana (thale-cress) (66)

Atha\AT2G21010

4 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\ATSYTF

1 of 13

Atha\BON1

1 of 13

Yes

Atha\BON2

1 of 13

Yes

Atha\BON3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RGLG2

1 of 13

Yes

Atha\RGLG3

1 of 13

Yes

Atha\RGLG4

1 of 13

Yes

Atha\SFC

1 of 13

Atha\SYTD

1 of 13

Atha\ZAC

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\TCB1

2 of 13

Yes

Scer\TCB2

2 of 13

Yes

Scer\TCB3

2 of 13

Yes

Scer\AGE1

1 of 13

Scer\AGE2

1 of 13

Scer\GTS1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\mug190

2 of 12

Yes

Spom\SPCC962.01

2 of 12

Yes

Spom\syn1

2 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Syt7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

Syt1

7 of 13

Syt4

6 of 13

Sytα

6 of 13

Rph

5 of 13

5 of 13

5 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Git

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SYT7; synaptotagmin 7

10 of 14

604146

Hsap\LOC102724488

3 of 14

RPH3A; rabphilin 3A

3 of 14

612159

SYT1; synaptotagmin 1

3 of 14

185605

BAKER-GORDON SYNDROME; BAGOS

SYT2; synaptotagmin 2

3 of 14

SYNAPTOTAGMIN 2; SYT2

congenital myasthenic syndrome 7

SYT3; synaptotagmin 3

3 of 14

600327

SYT4; synaptotagmin 4

3 of 14

600103

SYT5; synaptotagmin 5

3 of 14

600782

SYT6; synaptotagmin 6

3 of 14

607718

SYT8; synaptotagmin 8

3 of 14

607719

SYT9; synaptotagmin 9

3 of 14

613528

SYT10; synaptotagmin 10

3 of 14

SYT11; synaptotagmin 11

3 of 14

608741

SYT15; synaptotagmin 15

3 of 14

608081

SYT17; synaptotagmin 17

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Syt7 - Drep2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Syt1

enhanceable

Syt7

(Guan et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68618

DroID - A comprehensive database of gene and protein interactions.

FBgn0039900

MIST (protein-protein) - An integrated Molecular Interaction Database

43783

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102B3-102B3

Sequence location

4:278,685..306,481 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102B3-102B3

Limits computationally determined from genome sequence between P{SUPor-P}Crk^KG00336&P{SUPor-P}KG00711 and P{SUPor-P}KG02769

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

101F-102

(Lloyd et al., 2000)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

23394

y¹; Mi{ET1}Syt7^MB01453

60791

y¹; Mi{MIC}Syt7^MI06277

27279

y¹ v¹; P{TRiP.JF02590}attP2

77770

y¹ w^*; Mi{Trojan-GAL4.0}Syt7^{MI06277-TG4.0}

94776

y¹ w¹¹¹⁸; Mi{DH.0}Syt7^{MI06277-DH.PT-GFSTF.0}

Kyoto

119292

y¹ w¹¹¹⁸; TI{TI}FRT101F Syt7^D

118904

y¹ w¹¹¹⁸; Mi{DH.0}Syt7^{MI06277-DH.PT-GFSTF.0}

NIG-Fly

2381Ra-3

P{NIG.2381Ra}3

HMJ22333

y¹ v¹; P{TRiP.HMJ22333}attP40/CyO

VDRC

v24988

w¹¹¹⁸; P{GD8644}v24988

v24989

w¹¹¹⁸; P{GD8644}v24989/TM3

v341925

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01191}attP40/CyO-GFP

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (113)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE44043

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039900

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039900

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Syt7 contains highly conserved calcium binding sites.

(Adolfsen et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Syt7 CG10322

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG2381 and CG10322 merged as CG2381 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Syt7 CG2381

(Verstreken and Bellen, 2000.9.4)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG10322

(Haussmann et al., 2008)

CG2381

(National Institute of Genetics Fly Stocks, 2023-, Andlauer et al., 2014, White-Grindley et al., 2014, Haussmann et al., 2008, Whitfield et al., 2002)

SYT7

(Lloyd et al., 2000)

Syt 7

(Guan et al., 2011)

Syt VII

(Andrews and Chakrabarti, 2005, Adolfsen and Littleton, 2001)

dsyt7

(Adolfsen et al., 2004)

syt-7

(Scholz et al., 2019)

syt7

(Sauvola et al., 2021, Yang et al., 2018, Park et al., 2014, Saraswati et al., 2007, Craxton, 2004)

Name Synonyms

Synaptotagmin 7

(Andlauer et al., 2014)

Synaptotagmin VII

(Littleton, 2000)

Syt7

synaptotagmin 7

(Park et al., 2014)

Secondary FlyBase IDs

FBgn0039901

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 67 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43783

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V4C4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V4C4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43783/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039900

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039900

FlyMine - An integrated database for Drosophila genomics

FBgn0039900

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2381

MARRVEL_MODEL - MARRVEL (model organism gene)

43783

Linkouts

BioGRID - A database of protein and genetic interactions.

68618

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039900

DroID - A comprehensive database of gene and protein interactions.

FBgn0039900

DRSC - Results frm RNAi screens

FBgn0039900

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039900

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039900

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2381

Flygut - An atlas of the Drosophila adult midgut

FBgn0039900

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43783

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

-0.76

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