FlyBase Gene Report: Dmel\btsz

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Gene: Dmel\btsz

General Information

Symbol

Dmel\btsz

Species

D. melanogaster

Name

bitesize

Annotation Symbol

CG44012

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266756

Gene Model Status

Stock Availability

28 publicly available

Gene Summary

bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)10418, Granulophilin

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:14,804,092..14,875,488 [-]

Recombination map

3-56

RefSeq locus

NT_033777 REGION:14804092..14875488

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables neurexin family protein binding

inferred from biological aspect of ancestor with PANTHER:PTN005238642

(GO Reference Genome Project, 2011-)

enables small GTPase binding

inferred from electronic annotation with InterPro:IPR010911

(InterPro Project Members, 2004-)

Biological Process (12 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in actin filament organization

inferred from mutant phenotype

(Pilot et al., 2006)

involved_in apical junction assembly

inferred from mutant phenotype

(Pilot et al., 2006)

involved_in cortical actin cytoskeleton organization

inferred from mutant phenotype

(Jayanandanan et al., 2014)

involved_in establishment of planar polarity of embryonic epithelium

inferred from mutant phenotype

(Pilot et al., 2006)

involved_in gastrulation involving germ band extension

inferred from mutant phenotype

(Pilot et al., 2006)

involved_in larval salivary gland morphogenesis

inferred from mutant phenotype

(Maybeck and Röper, 2009)

involved_in lumen formation, open tracheal system

inferred from mutant phenotype

(Jayanandanan et al., 2014)

involved_in morphogenesis of embryonic epithelium

inferred from mutant phenotype

(Pilot et al., 2006)

involved_in positive regulation of cell size

inferred from mutant phenotype

(Serano and Rubin, 2003)

involved_in positive regulation of multicellular organism growth

inferred from mutant phenotype

(Serano and Rubin, 2003)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN005238642

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR010911

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Jayanandanan et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in exocytic vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000001477

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR001565

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000001477

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS -: Synaptotagmins are a family of membrane-trafficking proteins characterized by an N-terminal transmembrane region and tandem cytoplasmic C2 domains which mediate specific interactions. Some of the family can interact with lipids in a Ca²⁺-dependent manner, leading to Ca²⁺-regulated release of neurotransmitters and hormones in the nervous and endocrine system. (Adapted from PMID:24065953 and FBrf0210023).

Gene Model and Products

Number of Transcripts

9

Number of Unique Polypeptides

8

Please see the JBrowse view of Dmel\btsz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K657)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0334285

7376

1102

FBtr0334286

8811

2645

FBtr0334287

5606

1517

FBtr0334288

3037

708

FBtr0334289

2713

600

FBtr0334290

8309

1567

FBtr0334291

7481

1137

FBtr0334292

14849

3734

FBtr0334293

8282

1567

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0306400

121.5

1102

9.28

FBpp0306401

285.8

2645

5.28

FBpp0306402

164.9

1517

5.50

FBpp0306403

80.2

708

10.01

FBpp0306404

67.7

600

10.32

FBpp0306405

171.0

1567

8.99

FBpp0306406

125.5

1137

9.40

FBpp0306407

405.1

3734

5.78

FBpp0306408

171.0

1567

8.99

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1567 aa isoforms: btsz-PG, btsz-PJ

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\btsz using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.25

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

dorsal ectoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

stomatogastric nervous system primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Jayanandanan et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\btsz in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\btsz

View exonic expression by tissue for Dmel\btsz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266756

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3346167/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266756

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266756

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 33 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 27 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of btsz

Transgenic constructs containing regulatory region of btsz

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

(Ryder, 2004.4.26)

(Ryder, 2004.4.26)

(Ryder, 2004.4.26)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

btsz^J5-2

lethal, with Scer\GAL4^btl.PS

btsz^KK112184

lethal | germline clone

btsz^J5-2

lethal | recessive

btsz¹⁰⁴¹⁸

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

btsz^GD2989

partially lethal - majority die

btsz¹⁰⁴¹⁸

partially lethal - majority die | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

btsz^GD10224

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

btsz^GD10224

Sterility

Allele

semi-fertile | recessive

btsz^unspecified

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

btsz^GD2989

abnormal body color | recessive

btsz^unspecified

abnormal cell shape | embryonic stage

btsz^K13-4

decreased body size | adult stage | recessive

btsz^J5-2

decreased cell number | adult stage | recessive

btsz^J5-2

decreased cell size | adult stage | recessive

btsz^J5-2

some die during larval stage | recessive

btsz^J5-2

some die during pupal stage, with Scer\GAL4^pnr-MD237

btsz^GD2989

visible, with Scer\GAL4^pnr-MD237

btsz^GD10224

Phenotype manifest in

Allele

embryonic/larval salivary gland

btsz^K13-4

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

btsz^EP3567

embryonic epidermis

embryonic epidermis | embryonic stage 13, with Scer\GAL4^fkh.PH

btsz^EP3567

btsz^unspecified

larval tracheal system | embryonic stage

btsz^J5-2

btsz^unspecified

mesonotum, with Scer\GAL4^pnr-MD237

btsz^unspecified

tormogen cell, with Scer\GAL4^pnr-MD237

btsz^GD10224

tracheal lumen | embryonic stage

btsz^J5-2

btsz^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (50)

7 of 14

Yes

Yes

5 of 14

No

Yes

3 of 14

No

Yes

Hsap\LOC102724488

2 of 14

No

No

2 of 14

No

No

1

2 of 14

No

No

1

2 of 14

No

No

2 of 14

No

No

2

2 of 14

No

No

1

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (33)

7 of 14

Yes

Yes

5 of 14

No

Yes

3 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (35)

7 of 14

Yes

Yes

5 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (35)

6 of 13

Yes

Yes

5 of 13

No

Yes

Xtro\LOC100486361

3 of 13

No

Yes

3 of 13

No

No

2 of 13

No

Yes

Xtro\LOC100493529

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

Xtro\LOC100496796

1 of 13

No

No

Xtro\LOC100497338

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (44)

7 of 14

Yes

Yes

4 of 14

No

Yes

Drer\si:ch211-266g18.6

3 of 14

No

Yes

3 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\LOC103909492

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (15)

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP005288

8 of 12

Yes

Yes

Agam\AgaP_AGAP001800

2 of 12

No

No

Agam\AgaP_AGAP007942

2 of 12

No

No

Agam\AgaP_AGAP008650

2 of 12

No

No

Agam\AgaP_AGAP010653

2 of 12

No

No

Agam\AgaP_AGAP000430

1 of 12

No

No

Agam\AgaP_AGAP001690

1 of 12

No

No

Agam\AgaP_AGAP003615

1 of 12

No

Yes

Agam\AgaP_AGAP003725

1 of 12

No

No

Agam\AgaP_AGAP007646

1 of 12

No

No

Agam\AgaP_AGAP011036

1 of 12

No

No

Agam\AgaP_AGAP012252

1 of 12

No

No

Agam\AgaP_AGAP012631

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (41)

3 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (3)

2 of 13

Yes

No

2 of 13

Yes

No

1 of 13

No

No

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:btsz. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SYTL4; synaptotagmin like 4

7 of 14

SYTL5; synaptotagmin like 5

5 of 14

SYTL2; synaptotagmin like 2

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

two hybrid, pull down, western blot, anti tag western blot

(Pilot et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266756

MIST (protein-protein) - An integrated Molecular Interaction Database

3346167

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-56

Cytogenetic map

Sequence location

3R:14,804,092..14,875,488 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88D4-88D6

Limits computationally determined from genome sequence between P{EP}CG33967^EP666 and P{lacW}Hsc70-4^L3929;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

88D5-88D6

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-56

(FlyBase, 2016)

3-54.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (28)

Aberrations including deletions of this gene Aberrations including duplications of this gene

8658

w¹¹¹⁸; P{UAS-btsz.3}3

8659

w¹¹¹⁸; P{UAS-GFP.BLR}3

8660

w¹¹¹⁸; P{GUS-btsz.2}2/CyO

8662

w¹¹¹⁸; P{GUS-btsz.2poly}2

11743

ry⁵⁰⁶ P{PZ}btsz¹⁰⁴¹⁸

66170

w^*; P{UASp-mCherry.btsz}attP2

40898

y¹ v¹; P{TRiP.HMS02146}attP40/CyO

37981

y¹ w^*; Mi{MIC}btsz^MI04766

11571

P{EP}btsz^G14810

7343R-1

v102608

P{KK112184}VIE-260B

v35205

w¹¹¹⁸; P{GD12208}v35205

More stocks available...

Genomic Clones (55)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (27)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266756

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Embryos injected with dsRNA made from templates generated with primers directed against this gene show defects in the organisation of the epithelium at the end of cellularisation. Gastrulation is completely arrested as the epithelium no longer elongates along the anteroposterior axis due to the epithelial cells losing their columnar organisation and becoming mesenchymal.

(Pilot et al., 2006)

dsRNA made from templates generated with primers directed against this gene severely affects gastrulation, resulting in the epithelium failing to extend properly. Defects are either strong or medium; that is, they are visible at the beginning of gastrulation or about 15 minutes later, respectively. The defects are penetrant (80%) and dose dependent.

(Pilot et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: btsz CG17304

(FlyBase Genome Annotators, 2012)

Source for merge of: l(3)10418 CG18280

(FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)

Source for merge of: l(3)10418 BcDNA:GH06647

(FlyBase, 1996-)

Source for merge of: l(3)10418 CG14858

(Levis, 2002.6.25)

Source for merge of: btsz Granulophilin

(Adolfsen and Littleton, 2001)

Additional comments

Annotations CG33555 and CG17304 merged as CG44012 in release 5.47 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2012)

Source for identity of btsz CG31306 was sequence comparison ( date:030917 ).

(FlyBase Genome Annotators, 2005, FlyBase, 1996-)

Annotations CG14858 and CG18280 merged as CG31306 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of l(3)10418 BcDNA:GH06647 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: btsz CG31306

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BcDNA:GH06647

Btsz

(Du et al., 2021, Weigelt et al., 2020, Yasuda and Fukuda, 2014, Jayanandanan et al., 2011, Halbleib and Nelson, 2006, Pilot, 2006, Pilot et al., 2006)

CG14858

(Pilot et al., 2006)

CG17304

(Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5)

CG18280

CG31306

CG33555

(Aradska et al., 2015, Hosono et al., 2015, Keleman et al., 2009.8.5)

CG44012

(Kim et al., 2021, Balakrishnan et al., 2015, Meadows, 2014.12.12, FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1)

CG7343

(Pilot et al., 2006, Giot et al., 2003, Jasper et al., 2002, Adolfsen and Littleton, 2001)

Granulophilin

l(3)10418

(Levis, 2002.6.25, Spradling et al., 1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

Name Synonyms

Bitesize

(Pradhan et al., 2023, Barrera-Velázquez and Ríos-Barrera, 2021, Campbell et al., 2019, Jayanandanan et al., 2014, Pilot et al., 2006)

Granulophilin

(Littleton, 2000)

bite size

(Maybeck and Röper, 2009)

bitesize

(Jayanandanan et al., 2011, Maybeck and Röper, 2009, Cavey et al., 2008, Fehon, 2006, Weis and Nelson, 2006)

Secondary FlyBase IDs

FBgn0038267
FBgn0063267
FBgn0051306
FBgn0038265
FBgn0038264
FBgn0038263
FBgn0010940
FBan0007343
FBpp0082473
FBpp0082472
FBtr0083014
FBtr0083013
FBan0031306
FBgn0053555
FBgn0264754
FBgn0044870

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 91 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3346167

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K657

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K657

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266756

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3346167/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266756

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266756

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG44012

MARRVEL_MODEL - MARRVEL (model organism gene)

3346167

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266756

DroID - A comprehensive database of gene and protein interactions.

FBgn0266756

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266756

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032155

MIST (protein-protein) - An integrated Molecular Interaction Database

3346167

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (106)