FB2026_03 , released September 17, 2026
Gene: Dmel\ARY
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General Information
Symbol
Dmel\ARY
Species
D. melanogaster
Name
Aldo-keto reductase on Y
Annotation Symbol
CG40064
Feature Type
FlyBase ID
FBgn0058064
Gene Model Status
Stock Availability
Enzyme Name (EC)
aldose reductase (1.1.1.21)
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

Aldehyde reductase Y

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
Y-
RefSeq locus
NC_024512 REGION:702430..704048
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000198921
Gene Group / Complex (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Catalytic Activity (EC/Rhea)
    aldose reductase (NADPH) activity
    (1) an alditol + NAD(+) = an aldose + NADH + H(+) (1.1.1.21)
    (2) an alditol + NADP(+) = an aldose + NADPH + H(+) (1.1.1.21)
    RHEA 12789:
    Summaries
    Gene Group / Complex (FlyBase)
    ALDOSE REDUCTASES -
    Aldose reductases catalyze the conversion between alditol and aldose, using NADP as a cofactor.
    Gene Model and Products
    Number of Transcripts
    2
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\ARY for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Gene model reviewed during 5.50

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0301807
    1338
    366
    FBtr0301808
    1392
    384
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    UniProt
    RefSeq ID
    GenBank
    FBpp0291021
    42.6
    366
    6.07
    FBpp0291022
    44.5
    384
    6.36
    Polypeptides with Identical Sequences

    None of the polypeptides share 100% sequence identity.

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ARY using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    2.81

    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\ARY in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Flygut - An atlas of the Drosophila adult midgut
    Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 0 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 1 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of ARY
    Transgenic constructs containing regulatory region of ARY
    Aberrations (Deficiencies and Duplications) ( 4 )
    Inferred from experimentation ( 4 )
    Inferred from location ( 0 )
      Variants
      Variant Molecular Consequences
      Alleles Representing Disease-Implicated Variants
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Phenotype manifest in
      Allele
      Orthologs
      Human Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      Homo sapiens (Human) (18)
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      1  
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      6 of 14
      No
      No
      3 of 14
      No
      No
      2 of 14
      No
      No
      2 of 14
      No
      No
      2 of 14
      No
      No
      1 of 14
      No
      No
      1 of 14
      No
      No
      2  
      1 of 14
      No
      No
      2  
      1 of 14
      No
      No
      2  
      Model Organism Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      Rattus norvegicus (Norway rat) (20)
      8 of 14
      Yes
      Yes
      8 of 14
      Yes
      Yes
      8 of 14
      Yes
      No
      8 of 14
      Yes
      No
      8 of 14
      Yes
      Yes
      8 of 14
      Yes
      Yes
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      Yes
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      Yes
      7 of 14
      No
      No
      1 of 14
      No
      No
      1 of 14
      No
      No
      1 of 14
      No
      No
      Mus musculus (laboratory mouse) (18)
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      7 of 14
      Yes
      No
      6 of 14
      No
      No
      6 of 14
      No
      No
      6 of 14
      No
      No
      6 of 14
      No
      No
      6 of 14
      No
      No
      6 of 14
      No
      No
      5 of 14
      No
      No
      1 of 14
      No
      No
      1 of 14
      No
      No
      Xenopus tropicalis (Western clawed frog) (22)
      5 of 13
      Yes
      No
      5 of 13
      Yes
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      3 of 13
      No
      No
      3 of 13
      No
      Yes
      3 of 13
      No
      Yes
      2 of 13
      No
      Yes
      1 of 13
      No
      Yes
      1 of 13
      No
      Yes
      1 of 13
      No
      No
      1 of 13
      No
      Yes
      1 of 13
      No
      Yes
      1 of 13
      No
      Yes
      1 of 13
      No
      Yes
      1 of 13
      No
      Yes
      Danio rerio (Zebrafish) (10)
      8 of 14
      Yes
      No
      7 of 14
      No
      Yes
      7 of 14
      No
      No
      7 of 14
      No
      No
      6 of 14
      No
      No
      5 of 14
      No
      Yes
      4 of 14
      No
      Yes
      4 of 14
      No
      Yes
      1 of 14
      No
      No
      1 of 14
      No
      No
      Caenorhabditis elegans (Nematode, roundworm) (15)
      9 of 14
      Yes
      No
      8 of 14
      No
      No
      7 of 14
      No
      No
      7 of 14
      No
      No
      6 of 14
      No
      No
      5 of 14
      No
      Yes
      5 of 14
      No
      Yes
      5 of 14
      No
      Yes
      5 of 14
      No
      Yes
      4 of 14
      No
      Yes
      4 of 14
      No
      No
      4 of 14
      No
      Yes
      3 of 14
      No
      Yes
      2 of 14
      No
      Yes
      1 of 14
      No
      No
      Anopheles gambiae (African malaria mosquito) (15)
      Arabidopsis thaliana (thale-cress) (20)
      9 of 13
      Yes
      No
      9 of 13
      Yes
      No
      8 of 13
      No
      No
      8 of 13
      No
      No
      8 of 13
      No
      No
      8 of 13
      No
      No
      7 of 13
      No
      No
      6 of 13
      No
      Yes
      5 of 13
      No
      No
      5 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      Saccharomyces cerevisiae (Brewer's yeast) (14)
      9 of 13
      Yes
      Yes
      9 of 13
      Yes
      Yes
      8 of 13
      No
      No
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      4 of 13
      No
      Yes
      2 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      Schizosaccharomyces pombe (Fission yeast) (7)
      7 of 12
      Yes
      No
      6 of 12
      No
      No
      3 of 12
      No
      Yes
      3 of 12
      No
      Yes
      3 of 12
      No
      Yes
      2 of 12
      No
      Yes
      1 of 12
      No
      No
      Escherichia coli (enterobacterium) (6)
      6 of 11
      Yes
      No
      3 of 11
      No
      Yes
      3 of 11
      No
      Yes
      1 of 11
      No
      No
      1 of 11
      No
      No
      1 of 11
      No
      No
      Other Organism Orthologs (via OrthoDB)
      Data provided directly from OrthoDB:ARY. Refer to their site for version information.
      Paralogs
      Paralogs (via DIOPT v9.1)
      Drosophila melanogaster (Fruit fly) (12)
      11 of 13
      11 of 13
      11 of 13
      11 of 13
      10 of 13
      10 of 13
      8 of 13
      2 of 13
      2 of 13
      2 of 13
      1 of 13
      1 of 13
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 3 )
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Y
        Recombination map
        Y-
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Heterochromatic, cytological location not yet determined.
        Maps to the Y chromosome by PCR, using as templates DNA from males and virgin females.
        Experimentally Determined Recombination Data
        Left of (cM)
        Right of (cM)
        Notes

        Maps to the Y chromosome by PCR, using as templates DNA from males and virgin females.

        Stocks and Reagents
        Stocks (1)
        Genomic Clones (3)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      New annotation (CG40064) in release 3 of the genome annotation.

                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: ARY CG40064

                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (7)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 56 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      Other crossreferences
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      DRSC - Results frm RNAi screens
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Flygut - An atlas of the Drosophila adult midgut
                      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      References (31)