FB2026_02 , released June 18, 2026
Gene: Dmel\ARY
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General Information
Symbol
Dmel\ARY
Species
D. melanogaster
Name
Aldo-keto reductase on Y
Annotation Symbol
CG40064
Feature Type
FlyBase ID
FBgn0058064
Gene Model Status
Stock Availability
Enzyme Name (EC)
aldose reductase (1.1.1.21)
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

Aldehyde reductase Y

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
Y-
RefSeq locus
NC_024512 REGION:702430..704048
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000198921
Gene Group (FlyBase)
Protein Family (UniProt)
-
Catalytic Activity (EC/Rhea)
aldose reductase (NADPH) activity
(1) an alditol + NAD(+) = an aldose + NADH + H(+) (1.1.1.21)
(2) an alditol + NADP(+) = an aldose + NADPH + H(+) (1.1.1.21)
RHEA 12789:
Summaries
Gene Group (FlyBase)
ALDOSE REDUCTASES -
Aldose reductases catalyze the conversion between alditol and aldose, using NADP as a cofactor.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\ARY for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0301807
1338
366
FBtr0301808
1392
384
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0291021
42.6
366
6.07
FBpp0291022
44.5
384
6.36
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ARY using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.81

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ARY in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ARY
Transgenic constructs containing regulatory region of ARY
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Inferred from location ( 0 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Phenotype manifest in
    Allele
    Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (18)
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    1  
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    6 of 14
    No
    No
    3 of 14
    No
    No
    2 of 14
    No
    No
    2 of 14
    No
    No
    2 of 14
    No
    No
    1 of 14
    No
    No
    1 of 14
    No
    No
    2  
    1 of 14
    No
    No
    2  
    1 of 14
    No
    No
    2  
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (20)
    8 of 14
    Yes
    Yes
    8 of 14
    Yes
    Yes
    8 of 14
    Yes
    No
    8 of 14
    Yes
    No
    8 of 14
    Yes
    Yes
    8 of 14
    Yes
    Yes
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    Yes
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    Yes
    7 of 14
    No
    No
    1 of 14
    No
    No
    1 of 14
    No
    No
    1 of 14
    No
    No
    Mus musculus (laboratory mouse) (18)
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    7 of 14
    Yes
    No
    6 of 14
    No
    No
    6 of 14
    No
    No
    6 of 14
    No
    No
    6 of 14
    No
    No
    6 of 14
    No
    No
    6 of 14
    No
    No
    5 of 14
    No
    No
    1 of 14
    No
    No
    1 of 14
    No
    No
    Xenopus tropicalis (Western clawed frog) (22)
    5 of 13
    Yes
    No
    5 of 13
    Yes
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    3 of 13
    No
    No
    3 of 13
    No
    Yes
    3 of 13
    No
    Yes
    2 of 13
    No
    Yes
    1 of 13
    No
    Yes
    1 of 13
    No
    Yes
    1 of 13
    No
    No
    1 of 13
    No
    Yes
    1 of 13
    No
    Yes
    1 of 13
    No
    Yes
    1 of 13
    No
    Yes
    1 of 13
    No
    Yes
    Danio rerio (Zebrafish) (10)
    8 of 14
    Yes
    No
    7 of 14
    No
    Yes
    7 of 14
    No
    No
    7 of 14
    No
    No
    6 of 14
    No
    No
    5 of 14
    No
    Yes
    4 of 14
    No
    Yes
    4 of 14
    No
    Yes
    1 of 14
    No
    No
    1 of 14
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (15)
    9 of 14
    Yes
    No
    8 of 14
    No
    No
    7 of 14
    No
    No
    7 of 14
    No
    No
    6 of 14
    No
    No
    5 of 14
    No
    Yes
    5 of 14
    No
    Yes
    5 of 14
    No
    Yes
    5 of 14
    No
    Yes
    4 of 14
    No
    Yes
    4 of 14
    No
    No
    4 of 14
    No
    Yes
    3 of 14
    No
    Yes
    2 of 14
    No
    Yes
    1 of 14
    No
    No
    Anopheles gambiae (African malaria mosquito) (15)
    Arabidopsis thaliana (thale-cress) (20)
    9 of 13
    Yes
    No
    9 of 13
    Yes
    No
    8 of 13
    No
    No
    8 of 13
    No
    No
    8 of 13
    No
    No
    8 of 13
    No
    No
    7 of 13
    No
    No
    6 of 13
    No
    Yes
    5 of 13
    No
    No
    5 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    Saccharomyces cerevisiae (Brewer's yeast) (14)
    9 of 13
    Yes
    Yes
    9 of 13
    Yes
    Yes
    8 of 13
    No
    No
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    4 of 13
    No
    Yes
    2 of 13
    No
    No
    2 of 13
    No
    No
    2 of 13
    No
    No
    2 of 13
    No
    No
    2 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    Schizosaccharomyces pombe (Fission yeast) (7)
    7 of 12
    Yes
    No
    6 of 12
    No
    No
    3 of 12
    No
    Yes
    3 of 12
    No
    Yes
    3 of 12
    No
    Yes
    2 of 12
    No
    Yes
    1 of 12
    No
    No
    Escherichia coli (enterobacterium) (6)
    6 of 11
    Yes
    No
    3 of 11
    No
    Yes
    3 of 11
    No
    Yes
    1 of 11
    No
    No
    1 of 11
    No
    No
    1 of 11
    No
    No
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:ARY. Refer to their site for version information.
    Paralogs
    Paralogs (via DIOPT v9.1)
    Drosophila melanogaster (Fruit fly) (12)
    11 of 13
    11 of 13
    11 of 13
    11 of 13
    10 of 13
    10 of 13
    8 of 13
    2 of 13
    2 of 13
    2 of 13
    1 of 13
    1 of 13
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 3 )
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Y
      Recombination map
      Y-
      Cytogenetic map
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Heterochromatic, cytological location not yet determined.
      Maps to the Y chromosome by PCR, using as templates DNA from males and virgin females.
      Experimentally Determined Recombination Data
      Left of (cM)
      Right of (cM)
      Notes

      Maps to the Y chromosome by PCR, using as templates DNA from males and virgin females.

      Stocks and Reagents
      Stocks (1)
      Genomic Clones (3)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    New annotation (CG40064) in release 3 of the genome annotation.

                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: ARY CG40064

                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (7)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 63 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    DRSC - Results frm RNAi screens
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Flygut - An atlas of the Drosophila adult midgut
                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    References (30)