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FB2026_01
,
released March 12, 2026
g-l, glossy-like
nuclear protein in the Notch pathway - An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive Notch signaling.
Please see the JBrowse view of Dmel\sno for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
5.756 (longest cDNA)
None of the polypeptides share 100% sequence identity.
1547 (aa)
Interacts with vg for function in the wing disk. Interacts with Su(H) for function in the eye disk.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sno using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
sno protein is first detected in nuclei at the syncytial blastoderm stage. At the cellular blastoderm stage, it is detected in all nuclei except for the pole cells. At gastrulation, sno protein is detected transiently in mesodermal precursors but shuts off as soon as they invaginate. At stage 8, a higher level of sno protein is observed in the midline cell precursors than in the surrounding epidermal cells. Between stages 11 and 14, high levels are seen uniformly throughout the epidermis. By stage 16, high levels of expression are estricted to the CNS. In larvae, sno protein is expressed in all of the imaginal discs. It is ubiquitous in leg discs but is present at a higher level in the central tarsal region. It is also present in all cells of the wing and eye discs. During oogenesis, sno protein is detected in follicle cell nuclei but not in nurse cell or oocyte nuclei.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sno in JBrowseMapping based on sno71e3.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
sno lies within a 200bp genomic walk bridging P{white-un4}BE1305 and wy.
Males and females homozygous for viable alleles have notched wings, thickened, Confluens-like wing veins with deltas at the junctions of the longitudinal veins and the margins, extra hairs on thorax and wings, shortened tarsal segments, and roughened, shiny bright, somewhat mottled eyes, closely resembling Nfa-g. All macrochaetae thin and delicate. Phenotype almost completely suppressed by euchromatic duplications of the Notch locus, e.g., Dp(1;2)51b. Insertions into heterochromatin, e.g., w+Y, are less effective in suppression. "fa" sno males and "fa" sno/+ sno females have exaggerated phenotypes and are semi-lethal; "spl" sno less extreme.
Source for identity of: sno CG1903
