Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
None of the polypeptides share 100% sequence identity.
Interacts with vg for function in the wing disk. Interacts with Su(H) for function in the eye disk.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sno using the Feature Mapper tool.
sno protein is first detected in nuclei at the syncytial blastoderm stage. At the cellular blastoderm stage, it is detected in all nuclei except for the pole cells. At gastrulation, sno protein is detected transiently in mesodermal precursors but shuts off as soon as they invaginate. At stage 8, a higher level of sno protein is observed in the midline cell precursors than in the surrounding epidermal cells. Between stages 11 and 14, high levels are seen uniformly throughout the epidermis. By stage 16, high levels of expression are estricted to the CNS. In larvae, sno protein is expressed in all of the imaginal discs. It is ubiquitous in leg discs but is present at a higher level in the central tarsal region. It is also present in all cells of the wing and eye discs. During oogenesis, sno protein is detected in follicle cell nuclei but not in nurse cell or oocyte nuclei.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sno in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: sno CG1903
sno is a downstream component of the N signalling pathway and is important for the specification of the wing dorsal/ventral organiser. sno has no role in lateral inhibition suggesting that it may contribute to the specificity between lateral and inductive N signalling pathways.
Males and females homozygous for viable alleles have notched wings, thickened, Confluens-like wing veins with deltas at the junctions of the longitudinal veins and the margins, extra hairs on thorax and wings, shortened tarsal segments, and roughened, shiny bright, somewhat mottled eyes, closely resembling Nfa-g. All macrochaetae thin and delicate. Phenotype almost completely suppressed by euchromatic duplications of the Notch locus, e.g., Dp(1;2)51b. Insertions into heterochromatin, e.g., w+Y, are less effective in suppression. "fa" sno males and "fa" sno/+ sno females have exaggerated phenotypes and are semi-lethal; "spl" sno less extreme.