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Citation
Stewart, M.J., Denell, R. (1993). Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.  Mol. Cell. Biol. 13(4): 2524--2535.
FlyBase ID
FBrf0059044
Publication Type
Research paper
Abstract

We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop grossly hypertrophied hematopoietic organs because of increased cell proliferation and extra rounds of endoreduplication in some hematopoietic cells. Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.

PubMed ID
PubMed Central ID
PMC359579 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cell. Biol.
    Title
    Molecular and Cellular Biology
    Publication Year
    1981-
    ISBN/ISSN
    0270-7306
    Data From Reference
    Aberrations (9)
    Alleles (4)
    Genes (7)
    Insertions (2)