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General Information
Symbol
Dmel\RpS6WG1288
Species
D. melanogaster
Name
FlyBase ID
FBal0030172
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lArB} insertion 12bp 5' from the origin of the RpS6 cDNA.

Insertion WG1288 of Bellen, Genes Dev 3:1288 , within 10bp of site of insertion of P in RpS6air8 in 5' untranslated region of RpS6. Impossible to determine precise insertion site as a small duplication accompanied insertion of P{lArB} element.

Insertion components
P{lArB}RpS6WG1288
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

RpS6WG1288/RpS6WG1288 embryonic macrophages do not show any changes in the phagocytic index (apoptotic cells clearance) compared to wild-type.

The prothoracic gland is 35% smaller than normal in heterozygous third instar larvae.

Heterozygotes show a delay in eclosion of up to 18 hours compared to wild type. This delay is reduced by the addition of 20-hydroxyecdysone.

Hemizygous males are developmentally delayed at all stages. Lethality generally occurs during extended third instar period when melanotic tumours arise.

Melanotic tumour phenotype similar to that of RpS6air8.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

RpS6WG1288/RpS6[+] is a suppressor | partially of visible phenotype of CycEJP

NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

RpS6WG1288/RpS6[+] is a suppressor | partially of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

RpS6WG1288/RpS6[+] is a non-suppressor of eye disc phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference

The defects in phagocytic apoptotic cells clearance displayed by homozygous pallko mutant embryos can be rescued by combination with RpS6WG1288 in homozygous, but not heterozygous state.

RpS6WG1288/+ restores eye size and reduces eye roughness in CycEJP homozygous adults. The number of mitotic cells in the second mitotic wave in the CycEJP eye disc is not increased by RpS6WG1288/+.

The addition of 20-hydroxyecdysone prevents the suppression of the CycEJP eye phenotype by RpS6WG1288/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

Expression of RpS6Scer\UAS.cLa under the control of Scer\GAL4P0206 suppresses the developmental delay seen in RpS6WG1288/+ flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Lethality is reverted by excision of the P{lArB} element, demonstrating the element to be responsible for the mutant phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)