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Inaki, M., Kojima, T., Ueda, R., Saigo, K. (2002). Requirements of high levels of Hedgehog signaling activity for medial-region cell fate determination in Drosophila legs: identification of pxb, a putative Hedgehog signaling attenuator gene repressed along the anterior-posterior compartment boundary.  Mech. Dev. 116(1-2): 3--18.
FlyBase ID
FBrf0151408
Publication Type
Research paper
Abstract

We show that high levels of Hedgehog signaling activity are essential for medial-region patterning in Drosophila legs. In mid-to-late third instar leg discs, high levels of Hedgehog signals repress the transcription of pxb, a newly identified gene encoding a transmembrane protein expressed specifically in the anterior compartment. Misexpression experiments indicate that Pxb may serve as a Hedgehog signaling attenuator capable of acting prior to Hedgehog-Patched interactions, suggesting that Hedgehog signaling in leg discs includes a pxb-repression-mediated positive feedback loop. RNA interference and clonal analysis show that neither Wingless nor Decapentaplegic signaling is required for pxb repression but high levels of Wingless signaling activity are essential for patterning in the leg ventral medial region.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
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