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Citation
Barnes, V.L., Strunk, B.S., Lee, I., Hüttemann, M., Pile, L.A. (2010). Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function.  BMC Biochem. 11(): 26.
FlyBase ID
FBrf0211360
Publication Type
Research paper
Abstract

SIN3 is a transcriptional repressor protein known to regulate many genes, including a number of those that encode mitochondrial components.By monitoring RNA levels, we find that loss of SIN3 in Drosophila cultured cells results in up-regulation of not only nuclear encoded mitochondrial genes, but also those encoded by the mitochondrial genome. The up-regulation of gene expression is accompanied by a perturbation in ATP levels in SIN3-deficient cells, suggesting that the changes in mitochondrial gene expression result in altered mitochondrial activity. In support of the hypothesis that SIN3 is necessary for normal mitochondrial function, yeast sin3 null mutants exhibit very poor growth on non-fermentable carbon sources and show lower levels of ATP and reduced respiration rates.The findings that both yeast and Drosophila SIN3 affect mitochondrial activity suggest an evolutionarily conserved role for SIN3 in the control of cellular energy production.

PubMed ID
PubMed Central ID
PMC2909972 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMC Biochem.
    Title
    BMC Biochemistry
    Publication Year
    2000-
    ISBN/ISSN
    1471-2091
    Data From Reference